biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosisbioph-24Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSОбзор механизмов селективного накопления фотосенсибилизаторов различной химической структуры в опухолевой тканиReview of selective accumudation of photosensitizers with different chemical structure in tumor tissueМачинскаяЕ. А.MachinskayaE. A.machinskaya@niopik.ruИванова-РадкевичВ. И.Ivanova-RadkevichV. I.Научно-исследовательский институт органических полупродуктов и красителей, Москва, РоссияРоссияResearch Institute of Organic Intermediates and Dyes, MoscowRussian FederationРоссийский Университет дружбы народов, Москва, Россия; Научно-исследовательский институт органических полупродуктов и красителей, Москва, РоссияРоссияResearch Institute of Organic Intermediates and Dyes, MoscowRussian Federation201320122013242832Copyright © Мачинская Е.А., Иванова-Радкевич В.И., 20132013Мачинская Е.А., Иванова-Радкевич В.И.Machinskaya E.A., Ivanova-Radkevich V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/24

В статье представлен обзор существующих теорий, объясняющих механизмы селективного накопления фотосенсибилизаторов в опухолевых тканях. Рассмотрены варианты, связанные как с направленной доставкой соединений различной химической структуры в опухоль, так и с низкой скоростью элиминации фотосенсибилаторов из опухоли. Подробно описаны механизмы захвата опухолевыми клетками фотосенсибилизатора, связанного с липопротеинами, благодаря более высокой, по сравнению с нормальными клетками, экспрессии рецепторов липопротеинов низкой плотности; механизмы накопления фотосенсибилизатора в опухолевой ткани за счет поглощения находящимися там макрофагами; механизмы связывания фотосенсибилизатора порфириновой структуры коллагеновыми нитями, продукция которых увеличена в опухолевых клетках и ряд других механизмов. Показаны перспективы практического применения знания механизмов селективного накопления с целью искусственного увеличения селективности накопления фотосенсибилизатора в опухоли путем направленной доставкой препарата в патологические ткани. Проведен анализ существующих в мире направлений по поиску транспортных систем фотосенсибилизаторов.

 

The review of available theories explaining mechanisms of photosensitizer selective accumulation in tumor tissue is represented in the article. Variants associated with both targeted delivery of compounds with different chemical structure to tumor and low elimination rate of photosensitizers in the tumor are described. Details of tumor cell up-take of photosensitizer bounded with lipoproteins due to increased expression of low solidity lipoproteins receptors comparing with normal cells; mechanisms of photosensitizer accumulation in tumor tissue due to phagocytosis by macrophages localized in this area; mechanisms of binding of porphyrin-based photosensitizer by collagen fibers, production of which is increased in tumor cells, and other mechanisms are reviewed. Perspectives of practical application of knowledge about mechanisms of selective accumulation for induced increase in selectiveness of photosensitizer accumulation in tumor through targeted delivery of agent to pathological tissues are shown. Analysis of world trends in the search of transport systems for photosensitizers is performed.

 

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The authors declare that there are no conflicts of interest present.