References

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Biomedical Photonics

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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis

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Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEWS

Сонодинамическая терапия с фотосенсибилизаторами и ее комбинация с фотодинамической терапией в лечении злокачественных опухолей

Sonodynamic therapy with photosensitizers and its combination with photodynamic therapy in treatment of malignant tumors

Церковский

Д. А.

Zerkovskiy

D. A.

Александрова

Е. Н.

Alexandrova

E. N.

Лапцевич

Т. П.

Laptsevich

T. P.

Истомин

Ю. П.

Istomin

Ju. P.

istomin06@mail.ru

Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова, Лесной, Республика БеларусьБеларусьN.N. Alexandrova Republic Research and Practical Centre of oncology and medical radiology, Minsk, BelarusBelarus

2014

20062014

321823

2014

Церковский Д.А., Александрова Е.Н., Лапцевич Т.П., Истомин Ю.П.

Zerkovskiy D.A., Alexandrova E.N., Laptsevich T.P., Istomin J.P.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pdt-journal.com/jour/article/view/34

В обзоре подробно освещены механизмы, лежащие в основе применения сонодинамической терапии с фотосенсибилизаторами (ультразвук + фотосенсибилизатор), а также комбинации сонодинамической и фотодинамической терапии (ультразвук + фотосенсибилизатор + световое воздействие) для лечения злокачественных новообразований. Приведены и проанализированы данные по эффективности применения указанных методов с фотосенсибилизаторами различной химической структуры в экспериментальных исследованиях в системах in vitro и in vivo на различных опухолевых моделях, а также в клинических исследованиях.

The article reviews mechanisms of sonodynamic therapy with photosensitizers (ultrasound + photosensitizer) and combination of sonodynamic with photodynamic therapy (ultrasound + photosensitizer + light exposure) for treatment of malignant tumors. Efficacy of these methods with photosensitizers of different chemical structure in experimental study in vitro and in vivo on different tumor models and in clinical trials was assessed.

ультразвуксонодинамическая терапиякомбинированное лечениесоносенсибилизаторыфотосенсибилизаторы

ultrasoundsonodynamic therapycombined modality treatmentsonosensitizersphotosensitizers

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The authors declare that there are no conflicts of interest present.