biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2019-8-3-19-28bioph-346Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESАнализ эффективности фотодинамического отбеливания зубов с использованием фотосенсибилизатора хлорин е6Analysis of efficiency of photodynamic teeth bleaching with the use of photosensitizer chlorine e6КоршуноваА. В.KorshunovaA. V.

Москва

Moscow

korshunovaanna.cniis@gmail.comМакаровВ. И.MakarovV. I.

Москва

Moscow

РябоваА. В.RyabovaA. V.

Москва

Moscow

РоманишкинИ. Д.RomanishkinI. D.

Москва

Moscow

ЗоринаО. А.ZorinaO. A.

Москва

Moscow

КречинаЕ. К.KrechinaE. K.

Москва

Moscow

ПономаревГ. В.PonomarevG. V.

Москва

Moscow

Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургииРоссияFederal State Institution Central Research Institute of Dental and Maxillofacial SurgeryRussian FederationИнститут общей физики им. А.М. Прохорова РАНРоссияProkhorov General Physics Institute of the Russian Academy of SciencesRussian FederationЦентральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияFederal State Institution Central Research Institute of Dental and Maxillofacial Surgery; The First Sechenov Moscow State Medical UniversityRussian FederationНаучно-исследовательский институт биомедицинской химии имени В.Н. ОреховичаРоссияInstitute of Biomedical Chemistry of the Russian Academy of SciencesRussian Federation201919102019831928Copyright © Коршунова А.В., Макаров В.И., Рябова А.В., Романишкин И.Д., Зорина О.А., Кречина Е.К., Пономарев Г.В., 20192019Коршунова А.В., Макаров В.И., Рябова А.В., Романишкин И.Д., Зорина О.А., Кречина Е.К., Пономарев Г.В.Korshunova A.V., Makarov V.I., Ryabova A.V., Romanishkin I.D., Zorina O.A., Krechina E.K., Ponomarev G.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/346

Отбеливание зубов является одной из самых востребованных процедур в эстетической стоматологии. Трудно поддающиеся отбеливанию дисколориты, вызванные изменениями дентина или дефектами эмали, могут быть устранены путем окисления хромогенов с помощью химических агентов, проникающих в эмаль и дентин. В последние годы фотодинамическое отбеливание зубов (ФДОЗ) рассматривается как минимально инвазивный и относительно эффективный по времени метод, при котором не используется перекись водорода, применение которой приводит к повышенной чувствительности зубов. Для ФДОЗ может использоваться фотосенсибилизатор (ФС) хлорин е6, обладающий высоким квантовым выходом генерации синглетного кислорода, низкой фототоксичностью, быстрым выведением, с одной стороны, и способностью к фотообесцвечиванию, с другой. В настоящей работе представлены количественные данные исследования эффективности ФДОЗ с хлорином е6: изменение цвета для 100 зубов после процедуры, оценка проникновения ФС в ткани зуба, оценка внутритканевой эффективности генерации синглетного кислорода и интенсивности фотообесцвечивания ФС при лазерном воздействии. Статистически установлено, что за одну процедуру ФДОЗ насыщенность цвета зубов (С) изменяется в среднем на 0,5 тона по шкале VITA, а светлота цвета (L) в отдельных случаях повышается более чем на 10 единиц.

Teeth whitening is one of the most sought-after procedures in aesthetic dentistry. Discolorites that are difficult to whiten, caused by dentin changes or enamel defects, can be eliminated by oxidizing the chromogens with chemical agents that penetrate to the enamel and dentin. In recent years, the method of photodynamic bleaching (PDB) is considered to be minimally invasive. It does not use hydrogen peroxide that leads to increased sensitivity of teeth, and is relatively effective over time. A convenient solution for PDB would be to use chlorin e6 as a photosensitizer, which has a high quantum yield of singlet oxygen generation, low phototoxicity, rapid elimination, on the one hand, and photobleaching capability, on the other. This paper presents quantitative data on the study of the effectiveness of PDB with chlorine e6: color change for 100 teeth after the procedure, chlorine e6 penetration into the tooth tissues, evaluation of the interstitial efficiency of the generation of singlet oxygen and photobleaching of chlorine e6 during laser exposure. It has been statistically established that for one PDB procedure, the tooth color saturation (C) varies on average by 0.5 tones on the VITA scale, and the lightness of color (L) in some cases increases by more than 10 units.

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The authors declare that there are no conflicts of interest present.