biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2019-8-4-28-35bioph-387Research ArticleОБЗОРЫREVIEWSСовременное состояние методов коррекции инволюционных изменений кожи и место фотодинамической терапии среди нихCurrent state of methods of correction of involutional changes of skin and the place of photodynamic therapy among themБеймановаМ. А.BeimanovaM. A.

Москва

Moscow

beimanova@mail.ruПотекаевН. Н.PotekaevN. N.

Москва

Moscow

ПетунинаВ. В.PetuninaV. V.

Москва

Moscow

Московский научно-практический центр дерматовенерологии и косметологииРоссияMoscow Research and Practical Center for Dermatovenereology and CosmetologyRussian FederationМосковский научно-практический центр дерматовенерологии и косметологии; Российский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияMoscow Research and Practical Center for Dermatovenereology and Cosmetology; The Russian National Research Medical University named after N.I. PirogovRussian FederationРоссийский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияThe Russian National Research Medical University named after N.I. PirogovRussian Federation201918022020842835Copyright © Бейманова М.А., Потекаев Н.Н., Петунина В.В., 20202020Бейманова М.А., Потекаев Н.Н., Петунина В.В.Beimanova M.A., Potekaev N.N., Petunina V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/387

Данная работа представляет собой обзор современных научных данных о процессах старения кожи, а также о перспективе использования метода фотодинамической терапии для коррекции инволюционных изменений кожи у возрастного населения. Приводятся данные прогнозируемого увеличения продолжительности жизни и, как следствие, потенциального риска возникновения патологий, в том числе кожной локализации. Увеличение продолжительности жизни также демонстрирует и социализацию пожилого населения, вместе с тем возрастающую потребность в преображении и коррекции инволюционных изменений кожи, но, учитывая риски в связи с наличием хронических заболеваний и возрастающей малигнизации данной когорты, следует тщательно подбирать методики, учитывая вышеперечисленные особенности. Одним из таких методов является фотодинамическая терапия. Фотодинамическая терапия активно применяется в онкологии, а в последнее время все чаще показывает свою эффективность в эстетическом направлении, соответственно прогнозируемо может использоваться не только у онкологических больных, но и возрастной когорты.

This work is a review of modern scientific data on the process of aging, as well as the prospect of using photodynamic therapy for correction of involutional skin changes in the age cohorts, cohorts with a burdened medical history, including cancerous and precancerous skin neoplasms. The data on the predicted increase in life expectancy and, as a consequence, the potential risk of pathologies, including those with skin localization, progression of malignancy processes, as well as the formation of de novo elements, is presented. The increase in life expectancy also demonstrates the socialization of the elderly population, along with the increasing need for correction of involutional skin changes. However, considering the risks associated with the chronic diseases and increased malignancy in this cohort, methods have to be carefully selected. One such technique is photodynamic therapy (PDT). PDT is actively used in oncology, and recently has been increasingly showing its aesthetic effectiveness. It can be predictably used not only on cancer patients, but also in an age cohort.

фотодинамическая терапиякоррекция инволюционных измененийактинический кератозphotodynamic therapycorrection of involutional changesactinic keratosisReferencesTobin D.J. Introduction to skin aging // J Tissue Viability. – 2017. Vol. 26(1). – P. 37–46.Tobin D.J. Introduction to skin aging, J Tissue Viability, 2017, vol. 26(1), pp. 37–46.Юсова Ж.Ю. Инволюционные изменения кожи: классификация и ультразвуковые изменения. В сборнике: Перспективы развития современной медицины, Сборник научных трудов по итогам международной научно-практической конференции. – Воронеж, 2014. – 170 с.Yusova Zh.Yu. Involutional skin changes: classification and ultrasound changes. In Perspektivy razvitiya sovremennoj mediciny. Sbornik nauchnykh trudov po itogam mezhdunarodnoi nauchnoprakticheskoi konferentsii [Prospects for modern medicine development. Conference proceedings]. Voronezh, 2014. 170 p.Addor F.A.S. Beyond photoaging: additional factors involved in the process of skin aging // Clin Cosmet Investig Dermatol. 2018. – Vol. 11. – P. 437–443. doi: 10.2147/CCID.S177448Addor F.A.S. Beyond photoaging: additional factors involved in the process of skin aging, Clin Cosmet Investig Dermatol, 2018, vol. 11, pp. 437–443. doi: 10.2147/CCID.S177448Schikowski T., Krutmann J. Air pollution (particulate matter and nitrogen dioxide) and skin aging // Hautarzt. – 2019. – Vol. 70(3). – P. 158–162. (in German)Schikowski T., Krutmann J. Air pollution (particulate matter and nitrogen dioxide) and skin aging, Hautarzt, 2019, vol. 70(3), pp. 158–162. (in German)Shah A.R., Kennedy P.M. The Aging Face // Med Clin North Am. 2018. – Vol. 102(6). – P. 1041–1054. doi: 10.1016/j.mcna.2018.06.006Shah A.R., Kennedy P.M. The Aging Face, Med Clin North Am, 2018, vol. 102(6), pp. 1041–1054. doi: 10.1016/j.mcna.2018.06.006Bhatt N., Agrawal S., Mehta K. Risk factors and self-perception for facial aging among Nepalese population // J Cosmet Dermatol. 2019. doi: 10.1111/jocd.12885Bhatt N., Agrawal S., Mehta K. Risk factors and self-perception for facial aging among Nepalese population, J Cosmet Dermatol, 2019. doi: 10.1111/jocd.12885Kammeyer A., Luiten R.M. Oxidation events and skin aging // Ageing Res Rev. – 2015. – Vol. 21. – P. 16–29. doi: 10.1016/j.arr.2015.01.001Kammeyer A., Luiten R.M. Oxidation events and skin aging, Ageing Res Rev, 2015, vol. 21, pp. 16–29. doi: 10.1016/j.arr.2015.01.001Baltes P.B., Baltes M.M. Psychological perspectives on s ful aging: The model of selective optimization with compensation. In Baltes P.B., Baltes M.M, editors. (Eds.), Successful aging: Perspectives from the behavioral sciences. – United Kingdom: Cambridge University Press, 1990. – P. 1–34.Baltes P.B., Baltes M.M. Psychological perspectives on successful aging: The model of selective optimization with compensation. In Successful aging: Perspectives from the behavioral sciences. United Kingdom, Cambridge University Press, 1990. pp. 1–34.Kahana E., Kahana B. Contextualizing successful aging: New directions in age-old search. In Settersten R. Jr, editor. (Ed.), Invitation to the life course: A New look at old age. – Amityville, NY: Baywood Publishing Company, 2003. – P. 225–255.Kahana E., Kahana B. Contextualizing successful aging: New directions in age-old search. In Invitation to the life course: A New look at old age. Amityville, NY, Baywood Publishing Company, 2003. pp. 225–255.Kahana E., Kahana B., Kercher K. Emerging lifestyles and p tive options for successful aging // Ageing International. – 2003. Vol. 28. – P. 155–180.Kahana E., Kahana B., Kercher K. Emerging lifestyles and proactive options for successful aging, Ageing International, 2003, vol. 28, pp. 155–180.Depp C.A., Jeste D.V. Definitions and predictors of successful aging: A comprehensive review of larger quantitative studies // American Journal of Geriatric Psychiatry. – 2006. – Vol. 14. – P. 6–20. doi: 10.1097/01.JGP.0000192501.03069.bcDepp C.A., Jeste D.V. Definitions and predictors of successful aging: A comprehensive review of larger quantitative studies, American Journal of Geriatric Psychiatry, 2006, vol. 14, pp. 6–20. doi: 10.1097/01.JGP.0000192501.03069.bcPhelan E.A., Larson E.B. “Successful aging”—Where next? // Journal of the American Geriatric Society. – 2002. – Vol. 50. – P. 1306–1308.Phelan E.A., Larson E.B. “Successful aging”—Where next?, Journal of the American Geriatric Society, 2002, vol. 50, pp. 1306–1308.Kontis V., Bennett J.E., Mathers C.D., Li G., Foreman K., Ezzati M. Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble // Lancet. – 2017. – Vol. 389. – P. 1323–1335. doi: 10.1016/S0140–6736(16)32381–9Kontis V., Bennett J.E., Mathers C.D., Li G., Foreman K., Ezzati M. Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble, Lancet, 2017, vol. 389, pp. 1323–1335. doi: 10.1016/S0140–6736(16)32381–9Vijg J., Le Bourg E. Aging and the Inevitable Limit to Human Life Span // Gerontology. – 2017. – Vol. 63(5). – P. 432–434. doi: 10.1159/000477210Vijg J., Le Bourg E. Aging and the Inevitable Limit to Human Life Span, Gerontology, 2017, vol. 63(5), pp. 432–434. doi:10.1159/000477210Shetty A.K., Kodali M., Upadhya R., Madhu L.N. Emerging Anti-Aging Strategies – Scientific Basis and Efficacy // Aging Dis. 2018. – Vol. 9(6). – P. 1165–1184. doi: 10.14336/AD.2018.1026Shetty A.K., Kodali M., Upadhya R., Madhu L.N. Emerging Anti-Aging Strategies – Scientific Basis and Efficacy, Aging Dis, 2018, vol. 9(6), pp. 1165–1184. doi: 10.14336/AD.2018.1026Kirkwood T.B.L. Why and how are we living longer? // Exp Physiol. 2017. – Vol. 102(9). – P. 1067–1074. doi: 10.1113/EP086205.Kirkwood T.B.L. Why and how are we living longer?, Exp Physiol, 2017, vol. 102(9), pp. 1067–1074. doi: 10.1113/EP086205.Шептий О.В., Круглова Л.С., Жукова О.В., Эктова Т.В., Ракша Д.А., Шматова А.А. Высокоэнергетическое лазерное излуче ние в дерматологии и косметологии // Российский журнал кожных и венерических болезней. – 2012. – № 6. – С. 39–43.Sheptii O.V., Kruglova L.S., Zhukova O.V., Ektova T.V., Raksha D.A., Shmatova A.A. High-energy laser radiation in dermatology and cosmetology, Rossiiskii zhurnal kozhnykh i venericheskikh boleznei, 2012, no. 6, pp. 39–43. (in Russian)Карабут М.М., Гладкова Н.Д., Фельдштейн Ф.И. Фракционный лазерный фототермолиз в лечении кожных дефектов: возможности и эффективность (обзор) // Современные техноло гии в медицине. – 2016. – Т. 8, №. 2. – С. 98–108. doi:10.17691/stm2016.8.2.14Karabut M.M., Gladkova N.D., Feldshtein F.I. Fractional laser photothermolysis in the treatment of skin defects: possibilities and effectiveness (review), Sovremennye tekhnologii v meditsine, 2016, vol. 8, no. 2, pp. 98–108. (in Russian) doi:10.17691/stm2016.8.2.14Потекаев Н.Н., Круглова Л.С. Лазер в дерматологии и косме тологии. – Алькор Паблишерс, 2018 г. – 290 с.Potekaev N.N., Kruglova L.S. Lazer v dermatologii i kosmetologii [Laser in dermatology and cosmetology]. Alkor Pablishers, 2018. 290 p.Gupta G. Diode Laser: Permanent hair “Reduction” Not “Removal” // Int J Trichology. – 2014. – Vol. 6(1). – P. 34. doi: 10.4103/09747753.136762.Gupta G. Diode Laser: Permanent hair “Reduction” Not “Removal”, Int J Trichology, 2014, vol. 6(1), pp. 34. doi: 10.4103/0974–7753.136762.Di Bernardo B.E., Pozner J.N. Intense Pulsed Light Therapy for Skin Rejuvenation // Clin Plast Surg. – 2016. – Vol. 43(3). – P. 535– 40. doi: 10.1016/j.cps.2016.03.008.Di Bernardo B.E., Pozner J.N. Intense Pulsed Light Therapy for Skin Rejuvenation, Clin Plast Surg, 2016, vol. 43(3), pp. 535–40. doi: 10.1016/j.cps.2016.03.008.Труфанов В.Д., Коган Е.А., Юцковская Я.А., Файзуллина Н.М., Иванов С.Ю. Радиоволны высокой частоты – инновационный подход к коррекции возрастных изменений кожи: клиниче ское, иммуногистохимическое исследование // СТМ. – 2016. Т. 8, № 1. – С. 106–116. doi: http://doi.org/10.17691/stm2016.8.1.14Trufanov V.D., Kogan E.A., Yutskovskaya Ya.A., Faizullina N.M., Ivanov S.Yu. High frequency radio waves – an innovative approach to the correction of age-related skin changes: clinical, immunohistochemical study, STM, 2016, vol. 8, no. 1, pp. 106–116. (in Russian) doi: http://doi.org/10.17691/stm2016.8.1.14Kharkwal G.B., Sharma S.K., Huang Y.Y., Dai T., Hamblin M.R. Photodynamic therapy for infections: clinical applications // Lasers Surg Med. – 2011. – Vol. 43(7). – P. 755–67. doi: 10.1002/lsm.21080Kharkwal G.B., Sharma S.K., Huang Y.Y., Dai T., Hamblin M.R. Photodynamic therapy for infections: clinical applications, Lasers Surg Med, 2011, vol. 43(7), pp. 755–67. doi: 10.1002/lsm.21080Gao Y., Wang H.L., Wang W.S., et al. Treatment of lip florid pap illomatosis with topical ALA-PDT combined with curettage: Outcome and safety // Photodiagnosis Photodyn Ther. – 2016. Vol. 15. – P. 83–7. doi: 10.1016/j.pdpdt.2016.05.012Gao Y., Wang H.L., Wang W.S., Liu J., Lu Y.G. Treatment of lip florid papillomatosis with topical ALA-PDT combined with curettage: Outcome and safety, Photodiagnosis Photodyn Ther, 2016, vol. 15, pp. 83–7. doi: 10.1016/j.pdpdt.2016.05.012Kohl E., Torezan L.A.R., Landthaler M., Szeimies R.M. Aesthetic effects of topical photodynamic therapy // J Eur Acad Dermatol Venereol. – 2010. – Vol. 24. – P. 1261– 9.Kohl E., Torezan L.A.R., Landthaler M., Szeimies R.M. Aesthetic effects of topical photodynamic therapy, J Eur Acad Dermatol Venereol, 2010, vol. 24, pp. 1261– 9.Lucena S.R., Salazar N., Gracia-Cazaña T. Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer // Int J Mol Sci. – 2015. – Vol. 16(10). – P. 25912–33. doi: 10.3390/ijms161025912Lucena S.R., Salazar N., Gracia-Cazaña T. Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer, Int J Mol Sci, 2015, vol. 16(10), pp. 25912–33. doi: 10.3390/ijms161025912Szeimies R.M., Torezan L., Niwa A. et al. Clinical, h cal and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy // Br J Dermatol. – 2012. – Vol. 167. – P. 150–9.Szeimies R.M., Torezan L., Niwa A., Valente N., Unger P., Kohl E., Schreml S., Babilas P., Karrer S., Festa-Neto C. Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy, Br J Dermatol, 2012, vol.167, pp. 150–9.Sanclemente G., Medina L., Villa J.F. et al. A prospective split‐face double‐blind randomized placebo‐controlled trial to assess the efficacy of methyl aminolevulinate + red‐light in patients with facial photodamage // J Eur Acad Dermatol Venereol. – 2011. Vol. 25. – P. 49–58.Sanclemente G., Medina L., Villa J.F., Barrera L.M., Garcia H.I. A prospective split‐face double‐blind randomized placebo‐controlled trial to assess the efficacy of methyl aminolevulinate + red‐light in patients with facial photodamage, J Eur Acad Dermatol Venereol, 2011, vol. 25, pp. 49–58.Philipp-Dormston W.G. Photodynamic therapy for a metic indications // G Ital Dermatol Venereol. – 2018. – Vol. 153(6). – P. 817–826. doi: 10.23736/S0392–0488.18.05982–5.Philipp-Dormston W.G. Photodynamic therapy for a metic indications // G Ital Dermatol Venereol. – 2018. – Vol. 153(6). – P. 817–826. doi: 10.23736/S0392–0488.18.05982–5.Karrer S., Kohl E., Feise K., et al. Photodynamic therapy for skin rejuvenation: review and summary of the literature--results of a consensus conference of an expert group for aesthetic photo dynamic therapy // J Dtsch Dermatol Ges. – 2013. – Vol. 11(2). – P. 137–48. doi: 10.1111/j.1610–0387.2012.08046.x.Karrer S., Kohl E., Feise K., et al. Photodynamic therapy for skin rejuvenation: review and summary of the literature--results of a consensus conference of an expert group for aesthetic photo dynamic therapy // J Dtsch Dermatol Ges. – 2013. – Vol. 11(2). – P. 137–48. doi: 10.1111/j.1610–0387.2012.08046.x.Heppt M.V., Steeb T., Leiter U., Berking C. Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis // J Eur Acad Dermatol Venereol. – 2019. doi: 10.1111/jdv.15459.Heppt M.V., Steeb T., Leiter U., Berking C. Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis // J Eur Acad Dermatol Venereol. – 2019. doi: 10.1111/jdv.15459.Nguyen K., Khachemoune A. An Update on Topical Photodynamic Therapy for Clinical Dermatologists // J Dermatolog Treat. – 2019. doi: 10.1080/09546634.2019.1569752.Nguyen K., Khachemoune A. An Update on Topical Photodynamic Therapy for Clinical Dermatologists // J Dermatolog Treat. – 2019. doi: 10.1080/09546634.2019.1569752.

The authors declare that there are no conflicts of interest present.