biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2020-9-2-18-28bioph-423Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESФотодинамическая терапия рака большого дуоденального сосочка и внепечёночных желчных протоковPhotodynamic therapy of cancer of large duodenal papilla and extrahepatic bile ductsСтранадкоЕ. Ф.StranadkoE. F.

Москва

Moscow

seph04@yandex.ruБарановА. В.BaranovA. V.

Москва

Moscow

ДуванскийВ. А.DuvanskyV. A.

Москва

Moscow

ЛобаковА. И.LobakovA. I.

Москва

Moscow

МорохотовВ. А.MorokhotovV. A.

Москва

Moscow

РябовМ. В.RiabovM. V.

Москва

Moscow

Государственный научный центр лазерной медицины им. О.К. Скобелкина ФМБАРоссияSkobelkin State Scientific Center of Laser Medicine FMBARussian FederationМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоРоссияMoscow Regional Research and Clinical Institute (“MONIKI”)Russian Federation202024072020921828Copyright © Странадко Е.Ф., Баранов А.В., Дуванский В.А., Лобаков А.И., Морохотов В.А., Рябов М.В., 20202020Странадко Е.Ф., Баранов А.В., Дуванский В.А., Лобаков А.И., Морохотов В.А., Рябов М.В.Stranadko E.F., Baranov A.V., Duvansky V.A., Lobakov A.I., Morokhotov V.A., Riabov M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/423

Проблема лечения пациентов с злокачественными новообразованиями (ЗНО) внепечёночных желчных протоков (ВЖП) и большого дуоденального сосочка (БДС) остается актуальной в связи с растущей заболеваемостью, высокой летальностью и выраженным снижением качества жизни пациентов, несмотря на проведение радикальной операции. Цель данного исследования заключалась в оценке эффективности применения фотодинамической терапии (ФДТ) у неоперабельных больных с злокачественной опухолью данной локализации. В исследование вошли 79 больных аденокарциномой БДС и ВЖП. Для лечения 29 больных применяли паллиативные желчеотводящие операции и ФДТ, 50 больным, составившим группу контроля, выполняли только желчеотводящие операции. Количество курсов ФДТ в основной группе составило от 1 до 3 в течение года. В общей сложности 29 больным проведено 52 курса ФДТ. Оценивали переносимость метода и продолжительность жизни больных.

The problem of treating patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla remains relevant due to the growing incidence, high mortality, and a pronounced decrease in the quality of life of patients, despite the radical surgery. The purpose of this study was to evaluate the effectiveness of photodynamic therapy (PDT) in inoperable patients with malignant tumors of these localizations.

The study is based on the treatment of 79 patients with adenocarcinoma of large duodenal papilla and extrahepatic bile ducts. 29 patients received palliative bile drainage operations with PDT. 50 patients in the control group only had palliative bile drainage operations. Patients in the study group received from 1 to 3 PDT courses in a year. In total, 29 patients received 52 PDT courses. The tolerance to the method and the life expectancy of patients were evaluated. The median survival of patients who underwent PDT was 18 months (11–60 months); in the control group – 11.5 months. PDT, in combination with bile drainage operation, is an effective method for the treatment of inoperable patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla in the absence of severe complications and with easy tolerance to therapy by patients. For the treatment and prolongation of life of patients whose radical surgical treatment is associated with a high risk of death, PDT seems to be the best treatment option. Results of PDT treatment for cancer of this localization are comparable with the results of radical surgeries and exceed those for palliative surgeries.

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The authors declare that there are no conflicts of interest present.