biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2020-9-4-15-22bioph-454Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИзучение терапевтических эффектов излучения с длиной волны 670 нм при различных типах диабетического макулярного отекаA study of therapeutic effects of 670 nm irradiation in different types of diabetic macular edemaRaminS.RaminS.

Тегеран

Tehran

AhadiM.AhadiM.

Тегеран

Tehran

sepid01@yahoo.comEbrahimiA.EbrahimiA.

Тегеран

Tehran

Университет медицинских наук Шахида БехештиИранStudent Research Committee of Shahid Beheshti University of Medical SciencesIslamic Republic of IranОфтальмологический центр БасирИранBasir Eye clinicIslamic Republic of Iran202004022021941522Copyright © Ramin S., Ahadi M., Ebrahimi A., 20212021Ramin S., Ahadi M., Ebrahimi A.Ramin S., Ahadi M., Ebrahimi A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/454

Целью данной исследовательской работы являлось изучение терапевтических эффектов излучения с длиной волны 670 нм у пациентов с диабетическим макулярным отеком. Ряд предыдущих исследований свидетельствует о положительном эффекте красного инфракрасного излучения при некоторых заболеваниях глаз, таких как макулодистрофия (дегенерация желтого пятна), макулярный отек и пигментный ретинит. Наше исследование было проведено на 45 глазах у 26 больных сахарным диабетом в возрасте от 51 до 80 лет с макулярным отеком. Всем пациентам были проведены определение остроты зрения, осмотр глаз щелевой лампой, фундоскопия и оптическая когерентная томография. Ни у одного из пациентов не было пролиферативной ретинопатии. Для лечения нами был применен портативный светодиодный прибор (Warp 10, Quantum devices). Пациенты держали светодиод на расстоянии 3 см от глаза в течение 240 сек в течение 3 мес. Все офтальмологические исследования были повторены через 1, 2 и 3 мес после проведения лечебной процедуры. Через 3 мес средняя острота зрения улучшилась с показателем логарифма минимального угла разрешения 0,44 ± 0,38 до 0,27 ± 0,24, что показало увеличение показателя остроты зрения на 1,52 ± 1,16 после лечения (р<0,001). Средняя центральная толщина сетчатки в области макулы уменьшилась с 381,49 ± 144,40 мкм до 359,72 ± 128,84 мкм (р=0,050). У пациентов с легкой и умеренной непролиферативной диабетической ретинопатией средняя толщина сетчатки уменьшилась до 52,06 ± 67,78 и 52,06 ± 67,78 мкм, соответственно, а у пациентов с тяжелой ретинопатией наблюдалось увеличение на 34,93 ± 65,65 мкм (р<0,001). Помимо того, степень макулярного отека не повлияла на окончательный результат лечения (р>0,05). Фотобиомодуляция была эффективной при диабетическом макулярном отеке, в частности, у пациентов с легкой и умеренной диабетической ретинопатией.

The purpose of this study was to investigate the therapeutic effects of 670 nm irradiation in patients with diabetic macular edema. In several studies, positive effects of red/near-infrared irradiation showed in a range of ocular diseases such as macular degeneration, macular edema, and retinitis pigmentosa. This study was conducted on forty five eyes of 26 diabetic patients with macular edema between the ages of 51 and 80.

Measurement of visual acuity and slit lamp examination, funduscopy, and optical coherence tomography were performed in all subjects. None of the patients had proliferative retinopathy. We used a portable LED device (Warp 10, Quantum Devices) for treatment. Patients held this device at a distance of 3 cm from their eyes for 240 seconds for three months. Full ophthalmic examinations were repeated 1, 2, and 3 months after treatment.

After 3 months, the mean visual acuity improved from 0.44 ± 0.38 log MAR to 0.27 ± 0.24 log MAR and vision increased by 1.52 ± 1.16 lines post treatment (р<0.001). The mean central macula thickness decreased from 381.49 ± 144.40 μm to 359.72 ± 128.84 μm (р=0.050). In patients with mild and moderate nonproliferative diabetic retinopathy, the mean central retinal thickness decreased 52.06 ± 67.78 μm and 39.27 ± 44.69 μm, respectively, but patients with severe type showed an increase of 34.93 ± 65.65 μm in the mean central retinal thickness (р<0.001). Also, the severity of macular edema had no effect on final outcomes (р>0.05). Photobiomodulation can positively affect diabetic macular edema, especially in patients with mild to moderate diabetic retinopathy.

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The authors declare that there are no conflicts of interest present.