biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2020-9-4-23-30bioph-455Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИнтраоперационная фотодинамическая терапия и гипертермическая внутрибрюшная химиотерапия при циторедуктивном хирургическом лечении больных диссеминированной муцинозной карциномой аппендиксаIntraoperative photodynamic therapy and hyperthermic intraperitoneal chemotherapy in cytoreductive treatment of patients with disseminated mucinous carcinoma of appendixСидоровД. В.SidorovD. V.

Москва

Moscow

ГришинН. А.GrishinN. A.

Москва

Moscow

grishinlap@mail.ruЛожкинМ. В.LozhkinM. V.

Москва

Moscow

ТроицкийА. А.TroitskyA. A.

Москва

Moscow

МошуровР. И.MoshurovR. I.

Москва

Moscow

БыкасовС. А.BykasovS. A.

Москва

Moscow

УрловаА. Н.UrlovaA. N.

Москва

Moscow

ФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

МНИОИ им. П.А. Герцена - филиал ФГБУ «НМИЦ радиологии» Минздрава РоссииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian Federation202004022021942330Copyright © Сидоров Д.В., Гришин Н.А., Ложкин М.В., Троицкий А.А., Мошуров Р.И., Быкасов С.А., Урлова А.Н., Филоненко Е.В., 20212021Сидоров Д.В., Гришин Н.А., Ложкин М.В., Троицкий А.А., Мошуров Р.И., Быкасов С.А., Урлова А.Н., Филоненко Е.В.Sidorov D.V., Grishin N.A., Lozhkin M.V., Troitsky A.A., Moshurov R.I., Bykasov S.A., Urlova A.N., Filonenko E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/455

В статье представлен опыт хирургического лечения 57 больных псевдомиксомой брюшины аппендикулярного генеза. У 32 (56,1%) пациентов операция дополнена интраоперационной фотодинамической терапией (ИОФДТ), у других 25 (43,9%) больных проведена гипертермическая внутрибрюшная химиотерапия (ГИВХ). Представлен анализ по величине индекса перитонеального канцероматоза, полноте циторедукции, обьему выполненных операций, послеоперационным осложнениям и госпитальной летальности, отдаленным результатам лечения в двух группах. Показано, что при достоверно худших результатах по показателям полноты циторедукции, полученных в группе ИОФДТ по сравнению с группой ГИВХ, 5-летняя выживаемость в группе с ГИВХ составила 86,6%, с ИОФДТ – 65,2%. При этом в группе ИОФДТ был достоверно ниже показатель послеоперационных осложнений (11,1%) и отсутствовала  летальность, в группе ГИВХ эти показатели составили 23,8% и 12,0%, соответственно. Полученные результаты свидетельствуют о том, что метод ИОФДТ является эффективным и перспективным для использования при хирургическом лечении псевдомиксомы брюшины.

The article presents the experience of surgical treatment of 57 patients with peritoneal pseudomyxoma of appendicular genesis. In 32 (56.1%) patients, the operation was supplemented with intraoperative photodynamic therapy (IOPDT). In the other 25 (43.9%) patients, hyperthermic intraperitoneal chemotherapy (HIPEC) was performed. The analysis according to the value of the peritoneal carcinomatosis index, completeness of cytoreduction, the volume of operations performed, postoperative complications and hospital mortality, as well as long-term treat- ment results in two groups is presented. It was shown that with significantly worse results in terms of cytoreduction completeness obtained in the IOPDT group compared to the HIPEC group, the 5-year survival rate in the HIPEC group was 86.6%, with IOPDT - 65.2%. At the same time, in the IOPDT group, the rate of postoperative complications was significantly lower (11.1%), and there was no mortality; in the HIPEC group, these indicators were 23.8% and 12.0%, respectively. The results obtained indicate that the IOPDT method is an effective and promising direction in the surgical treatment of peritoneal pseudomyxoma.

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The authors declare that there are no conflicts of interest present.