biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2020-9-4-31-39bioph-456Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSФотодинамическая терапия в лечении интраэпителиальных неоплазий шейки матки, вульвы и влагалищаPhotodynamic therapy in the treatment of intraepithelial neoplasia of the cervix, vulva and vaginaФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

ТрушинаО. И.TrushinaO. I.

Москва

Moscow

НовиковаЕ. Г.NovikovaE. G.

Москва

Moscow

ЗароченцеваН. В.ZarochentsevaN. V.

Москва

Moscow

РовинскаяО. В.RovinskayaO. V.

Москва

Moscow

osya_92@mail.ruИванова-РадкевичВ. И.Ivanova-RadkevichV. I.

Москва

Moscow

КапринА. Д.KaprinA. D.

Москва

Moscow

МНИОИ им. П.А. Герцена - филиал ФГБУ «НМИЦ радиологии» Минздрава РоссииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии» Министерства здравоохранения Московской областиРоссияMoscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow RegionRussian FederationРоссийский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian FederationМНИОИ им. П.А. Герцена - филиал ФГБУ «НМИЦ радиологии» Минздрава России; Российский Университет дружбы народовРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)Russian Federation202004022021943139Copyright © Филоненко Е.В., Трушина О.И., Новикова Е.Г., Зароченцева Н.В., Ровинская О.В., Иванова-Радкевич В.И., Каприн А.Д., 20212021Филоненко Е.В., Трушина О.И., Новикова Е.Г., Зароченцева Н.В., Ровинская О.В., Иванова-Радкевич В.И., Каприн А.Д.Filonenko E.V., Trushina O.I., Novikova E.G., Zarochentseva N.V., Rovinskaya O.V., Ivanova-Radkevich V.I., Kaprin A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/456

В обзоре литературы представлен анализ эффективности лечения интраэпителиальной неоплазии I-II-III степени шейки матки (CIN), вульвы (VIN) и влагалища (VaIN) с использованием фотодинамической терапии (ФДТ). ФДТ – метод, основанный на воздействии светом после предварительного введения в организм фотосенсибилизатора с образованием синглетного кислорода, оказывающего цитотоксический эффект. Представлены результаты исследований по использованию ФДТ с различными фотосенсибилизаторами в комплексе лечебных мероприятий у больных с CIN, VIN, VaIN. Приведенные данные об эффективности и безопасности ФДТ, простота применения позволяют данную медицинскую технологию отнести к числу наиболее перспективных направлений в лечении различной степени выраженности интраэпителиальных изменений шейки матки, вульвы и влагалища. Представленная информация позволит акцентировать внимание на ФДТ и информировать врачей и научных сотрудников о широких перспективах применения данного метода в клинической практике.

In the present review the authors analyzed the effectiveness of treatment of intraepithelial neoplasia I-II-III of the cervix (CIN), vulva (VIN) and vagina (VaIN) using photodynamic therapy (PDT). PDT is a method based on exposure to light after preliminary introduction of a photosensitizer into the body with the formation of singlet oxygen, which has a cytotoxic effect. The results of research on the use of PDT with various photosensitizers in the complex of therapeutic measures in patients with CIN, VIN, VaIN are presented. These data on the effectiveness and safety of PDT, ease of use allow this medical technology to be attributed to one of the most promising areas in the treatment of pathological intraepithelial changes of the cervix, vulva and vagina. The presented information allows focusing the attention on the PDT method and informing doctors and researchers about the broad prospects for applying this treatment method in clinical practice.

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The authors declare that there are no conflicts of interest present.