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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bioph</journal-id><journal-title-group><journal-title xml:lang="ru">Biomedical Photonics</journal-title><trans-title-group xml:lang="en"><trans-title>Biomedical Photonics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2413-9432</issn><publisher><publisher-name>Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24931/2413-9432-2021-10-1-17-24</article-id><article-id custom-type="elpub" pub-id-type="custom">bioph-475</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Оптимизация антибактериальной терапии у пациентов с эндо-пародонтальными поражениями</article-title><trans-title-group xml:lang="en"><trans-title>Optimization of antibacterial therapy in patients with endo-periodontal lesions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салеев</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Saleev</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><email xlink:type="simple">rin-gul@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блашкова</surname><given-names>С. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Blashkova</surname><given-names>S. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крикун</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krikun</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салеева</surname><given-names>Г. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Saleeva</surname><given-names>G. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блашкова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blashkova</surname><given-names>J. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Валеева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Valeeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Казанский государственный медицинский университет Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Kazan State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>04</month><year>2021</year></pub-date><volume>10</volume><issue>1</issue><elocation-id>17–24</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Салеев Р.А., Блашкова С.Л., Крикун Е.В., Салеева Г.Т., Блашкова Ю.В., Валеева Е.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Салеев Р.А., Блашкова С.Л., Крикун Е.В., Салеева Г.Т., Блашкова Ю.В., Валеева Е.В.</copyright-holder><copyright-holder xml:lang="en">Saleev R.A., Blashkova S.L., Krikun E.V., Saleeva G.T., Blashkova J.V., Valeeva E.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pdt-journal.com/jour/article/view/475">https://www.pdt-journal.com/jour/article/view/475</self-uri><abstract><p>Для повышения качества и эффективности оказания медицинской помощи пациентам с воспалительными заболеваниями пародонта необходим поиск новых подходов к диагностике и лечению патологии. Целью исследования было изучить влияние излучения диодного лазера на патогенную микрофлору пародонтальных карманов (ПК) и корневых каналов (КК) у пациентов с эндо-пародонтальными поражениями (ЭПП). Проведена сравнительная оценка бактериального содержимого КК и ПК методом полимеразно-цепной реакции (ПЦР) до и после лечения с применением стоматологического диодного лазера (Doctor Smile Simpler, длина волны 980 нм) у 54 пациентов с ЭПП. Группу контроля составили 56 пациентов, которым проводилось лечение по общепринятой методике, включающей профессиональную гигиену рта, эндодонтическое лечение и кюретаж ПК. Критерием оценки явилось качественное содержание пародонтопатогенов в КК и ПК до и после лечения. Выявлено статистически значимое (p&lt;0,01) снижение обсемененности ПК и КК у пациентов с ЭПП после лазерной деконтаминации. Высокая технологичность использованных методик в сочетании с низкими рисками осложнений на этапах эндодонтического и пародонтологического лечения обеспечивает антибактериальный эффект и сокращает продолжительность воспалительных явлений. Результаты лечения пациентов с применением диодного лазера дают основание рекомендовать их использование в практике врача-стоматолога.</p></abstract><trans-abstract xml:lang="en"><p>To improve the quality and effectiveness of medical care for patients with inflammatory periodontal diseases, it is necessary to search for new approaches in both diagnosis and treatment. The aim of our study is to determine the effect of the diode laser on the pathogenic microflora of periodontal pockets and root canals in patients with endo-periodontal lesions (EPL). We carried out a comparative assessment of the bacterial contents of the root canals and periodontal pockets by polymerase chain reaction (PCR) before and after treatment with a diode laser (Doctor Smile Simpler, wavelength 980 nm) for 54 patients with EPL. The control group consisted of 56 patients who were treated according to the generally accepted method, including professional oral hygiene, endodontic treatment, and curettage of periodontal pockets. Evaluation criteria were a qualitative assessment of the content of periodontopathogens in the root canal and periodontal pocket before and after and treatment. As a result of our study, we found a statistically significant (p&lt;0.01) reduction in the colonization of periodontal pockets and root canals in patients with EPL after laser decontamination. The high technological effectiveness of the methods used in combination with the low risk of complications at the stages of endodontic and periodontological treatment provides an antibacterial effect and reduces the duration of inflammation. The results of treatment of patients using a diode laser give reason to recommend their use in the dental practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндо-пародонтальные поражения</kwd><kwd>эндодонтическое лечение</kwd><kwd>пародонтологическое лечение</kwd><kwd>пародонтопатогены</kwd><kwd>диодный лазер</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endo-periodontal lesions</kwd><kwd>endodontic treatment</kwd><kwd>periodontal treatment</kwd><kwd>periodontopathogens</kwd><kwd>diode laser</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Царев В.Н. 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