biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2021-10-1-25-31bioph-476Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSАнтимикробная и антимикотическая фотодинамическая терапия (обзор литературы)Antimicrobial and antimycotic photodynamic therapy (review of literature)СеменовД. Ю.SemyonovD. Yu.

Москва

Moscow

ВасильевЮ. Л.Vasil’evYu. L.

Москва

Moscow

y_vasiliev@list.ruДыдыкинС. С.DydykinS. S.

Москва

Moscow

СтранадкоЕ. Ф.StranadkoE. F.

Москва

Moscow

ШубинВ. К.ShubinV. K.

Москва

Moscow

БогомазовЮ. К.BogomazovYu. K.

Москва

Moscow

МорохотовВ. А.MorokhotovV. A.

Москва

Moscow

ЩербюкА. Н.ShcherbyukA. N.

Москва

Moscow

МорозовС. В.MorozovS. V.

Москва

Moscow

ЗахаровЮ. И.ZakharovYu. I.

Москва

Moscow

ГБУЗ МО «МОНИКИ им. М.Ф. Владимирского»РоссияMoscow Regional Clinical Research Institute named after M.F. Vladimirsky (MONIKI)Russian FederationФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Russian FederationФГБУ ГНЦ ЛМ им. О.К. Скобелкина ФМБА РоссииРоссияSkobelkin State Scientific Center of Laser Medicine FMBARussian Federation20211804202110125–31Copyright © Семенов Д.Ю., Васильев Ю.Л., Дыдыкин С.С., Странадко Е.Ф., Шубин В.К., Богомазов Ю.К., Морохотов В.А., Щербюк А.Н., Морозов С.В., Захаров Ю.И., 20212021Семенов Д.Ю., Васильев Ю.Л., Дыдыкин С.С., Странадко Е.Ф., Шубин В.К., Богомазов Ю.К., Морохотов В.А., Щербюк А.Н., Морозов С.В., Захаров Ю.И.Semyonov D.Y., Vasil’ev Y.L., Dydykin S.S., Stranadko E.F., Shubin V.K., Bogomazov Y.K., Morokhotov V.A., Shcherbyuk A.N., Morozov S.V., Zakharov Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/476

В обзоре литературы освещены возможности фотодинамической терапии (ФДТ) с использованием в качестве фотосенсибилизатора (ФС) ряда препаратов, в том числе на основе хлорина е6, фталоцианина алюминия, метиленового синего, при бактериальных и грибковых патологиях. Метод ФДТ изначально был разработан для лечения опухолевых заболеваний, в борьбе с которыми показал свою высокую эффективность и безопасность. В настоящее время ФДТ активно применяется при лечении пациентов с раком кожи, бронхов, желудка, шейки матки, гортани и других локализаций. Однако за все время существования метода были проведены многочисленные исследования, демонстрирующие новые возможности его применения. В настоящем обзоре освещен ряд научно-исследовательских работ, в которых была изучена эффективность и безопасность антимикробной и антимикотической ФДТ в экспериментах in vivo и in vitro. Выполнен обзор публикаций, посвященных изучению механизмов антимикробного действия ФДТ, а также изучающих влияние ФДТ на репаративные процессы в ране. В исследованиях, включенных в настоящий обзор, доказана высокая эффективность антимикробной и антимикотической ФДТ. Продемонстрирован противовоспалительный потенциал метода при лечении аутоиммунных заболеваний у людей.

This review highlights the possibilities of photodynamic therapy (PDT) using drugs based on chlorin e6, aluminum phthalocyanine, methylene blue as photosensitizers for bacterial and fungal pathologies. This method was developed initially to treat tumor diseases, where it had shown its high efficiency and safety. Now photodynamic therapy is actively used in the treatment of cancers of the skin, bronchi, stomach, cervix, larynx, or other regions. However, numerous studies have been carried out for the entire existence of the method, demonstrating new possibilities of its application. This review highlights a number of studies in which the efficacy and safety of antimicrobial and antimycotic PDT were studied in vivo and in vitro. It has been proven to have a positive effect on the reparative processes in the wound. An experimental study was carried out to study the effectiveness of photodynamic therapy in the treatment of peritonitis in mice. Demonstrated anti-inflammatory potential in the treatment of autoimmune diseases.

фотодинамическая терапияантибактериальная терапияаутоиммунные заболеваниямикозыN-диметилглюкаминовая соль хлорина е6photodynamic therapyantibacterial therapyautoimmune diseasesmycosisN-methylglucamine salt of chlorine e6ReferencesСтранадко Е.Ф., Кулешов И.Ю., Караханов Г.Я. Фотодинамическое воздействие на патогенные микроорганизмы (современное состояние проблемы антимикробной фотодинамической терапии) // Лазерная медицина. – 2010. – Т. 14 (2). – С. 52–56.Stranadko E. F., Kuleshov I. Yu., Karakhanov G. Ya. Photodynamic effect on pathogenic microorganisms (current state of the problem of antimicrobial photodynamic therapy). Laser medicine, 2010, No 14 (2), рр. 52–56. (in Russ.)Yang Y., Hu Y., Wang H. Targeting antitumor immune response for enhancing the efficacy of photodynamic therapy of Cancer: recent advances and future perspectives // Oxid Med Cell Longev. – 2016. – 5274084. doi: 10.1155/2016/5274084Yang Y., Hu Y., Wang H. Targeting antitumor immune response for enhancing the efficacy of photodynamic therapy of Cancer: recent advances and future perspectives. Oxid Med Cell Longev, 2016, 5274084. doi: 10.1155/2016/5274084Yano T., Wang K.K. Photodynamic therapy for gastrointestinal cancer // Photochem Photobiol. – 2020. – Vol. 96 (3). – P. 517–523. doi: 10.1111/php.13206.Yano T., Wang K.K. Photodynamic therapy for gastrointestinal cancer. Photochem Photobiol, 2020, Vol. 96 (3), pp. 517–523. doi: 10.1111/php.13206.Civantos FJ, Karakullukcu B, Biel M, et al. A Review of Photodynamic Therapy for Neoplasms of the Head and Neck // Advances in Therapy. – 2018. – Vol. 35. – P. 324–340. doi: 10.1007/s12325–018–0659–3Civantos FJ, Karakullukcu B, Biel M, et al. A Review of Photodynamic Therapy for Neoplasms of the Head and Neck. Advances in Therapy, 2018, Vol. 35, pp. 324–340. doi: 10.1007/s12325–018–0659–3Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy - mechanisms, photosensitizers and combinations // Biomed Pharmacother. – 2018. – Vol. 106. – P. 1098–1107. doi: 10.1016/j.biopha.2018.07.049Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy - mechanisms, photosensitizers and combinations. Biomed Pharmacother, 2018, Vol. 106, pp. 1098–1107. doi: 10.1016/j.biopha.2018.07.049Shen Y, Li M, Sun F, et al. Low-dose photodynamic therapyinduced increase in the metastatic potential of pancreatic tumor cells and its blockade by simvastatin // J. Photochem Photobiol B. – 2020. – Vol.207. – P. 111889. doi: 10.1016/j.jphotobiol.2020.111889Shen Y, Li M, Sun F, et al. Low-dose photodynamic therapyinduced increase in the metastatic potential of pancreatic tumor cells and its blockade by simvastatin. J. Photochem Photobiol B, 2020, Vol.207, pp. 111889. doi: 10.1016/j.jphotobiol.2020.111889Mallidi S., Anbil S., Bulin A.L., et al. Beyond the barriers of light penetration: strategies, perspectives and possibilities for photodynamic therapy // Theranostics. – 2016. – Vol. 6. – Р. 2458–2487. doi: 10.7150/thno.16183Mallidi S., Anbil S., Bulin A.L., et al. Beyond the barriers of light penetration: strategies, perspectives and possibilities for photodynamic therapy. Theranostics, 2016, Vol. 6, pp. 2458–2487. doi: 10.7150/thno.16183Chilakamarthi U., Giribabu L. Photodynamic therapy: past, present and future // Chem. Rec. – 2017. – Vol. 17. – Р. 775–802. doi: 10.1002/tcr.201600121.Chilakamarthi U., Giribabu L. Photodynamic therapy: past, present and future. Chem. Rec, 2017, Vol. 17, pp. 775–802. doi: 10.1002/tcr.201600121.Lee H.H., Choi M.G., Hasan T. Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique // Korean. J. Intern. Med. – 2017. – Vol. 32. – Р. 1–10. doi: 10.3904/kjim.2016.200Lee H.H., Choi M.G., Hasan T. Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique. Korean. J. Intern. Med, 2017, Vol. 32, pp. 1–10. doi: 10.3904/kjim.2016.200Лукьянец Е.А. Поиск новых фотосенсибилизаторов для фотодинамической терапии // Фотодинамическая терапия и фотодиагностика. – 2013. – Vol. 3. – C.3–16Lukyanets E. A. Search for new photosensitizers for photodynamic therapy. Photodynamic therapy and photodiagnostics, 2013, Vol. 3, pp. 3–16. (in Russ.)Zharova T. A. et al. Gonarthritis photodynamic therapy with chlorin e6 derivatives // Photodiagnosis and photodynamic therapy. – 2016. – Vol. 15. – Р. 88–93 doi: 10.1016/j.pdpdt.2016.06.002Zharova T. A. et al. Gonarthritis photodynamic therapy with chlorin e6 derivatives. Photodiagnosis and photodynamic therapy, 2016, Vol. 15, pp. 88–93 doi: 10.1016/j.pdpdt.2016.06.002Zharova TA et al. Correlation of synovial caspase-3 concentration and the photodynamic effectiveness in the osteoarthritis treatment // Photodiagnosis Photodyn Ther. – 2020. – Vol. 30. – P. 101669. doi: 10.1016/j.pdpdt.2020.101669Zharova TA et al. Correlation of synovial caspase-3 concentration and the photodynamic effectiveness in the osteoarthritis treatment. Photodiagnosis Photodyn Ther, 2020, Vol. 30, pp. 101669. doi: 10.1016/j.pdpdt.2020.101669Torchinov A.M., Umakhanova M.M., Duvansky R.A. et al. Photodynamic therapy of background and precancerous diseases of uterine cervi with photosensitisers of chlorine raw // Photodiagnosis and Photodynamic Therapy. – 2008. – Vol. 5(S1). – С. 45.Torchinov A.M., Umakhanova M.M., Duvansky R.A. et al. Photodynamic therapy of background and precancerous diseases of uterine cervi with photosensitisers of chlorine raw. Photodiagnosis and Photodynamic Therapy, 2008, Vol. 5(S1), pp. 45.Turubanova VD, Balalaeva IV Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine // J Immunother Cancer. – 2019. – Vol. 16 – Р. 350. doi: 10.1186/s40425–019–0826–3Turubanova VD, Balalaeva IV Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine. J Immunother Cancer, 2019, Vol. 16, pp. 350. doi: 10.1186/s40425–019–0826–3Дуванский В.А., Дзагнидзе Н.С., Бисеров О.В., Мараев В.В., Гаджиев Э.А. Микроциркуляция гнойных ран по данным лазерной допплеровской флоуметрии // Лазерная медицина. – 2007. – Т. 11(1). – С. 46–49.Duvansky V. A., Dzagnidze N. S., Biserov O. V. et al. Microcirculation of purulent wounds according to laser Doppler flowmetry data. Laser medicine, 2007, Vol. 11 (1), pp. 46–49. (in Russ.)Шин Е.Ф., Елисеенко В.И., Сорокатый А.А. Влияние фотодинамической терапии с фотодитазином, комплексированным с амфифильными полимерами на репаративные процессы // Лазерная медицина. – 2017. – Т. 21(3). – С. 31–35.Shin E. F., Yeliseenko V. I., Sorokaty A. A. Effects of photodynamic therapy with Photodithazine combined with amphiphilic polymers on reparative processes. Laser medicine, 2017, Vol. 21 (3), pp. 31–35. (in Russ.)Толстых М.П. Проблема комплексного лечения гнойных ран различного генеза и трофических язв: автореф. дис... канд. мед. наук // М.П. Толстых. – М., 2002. – 42 с.Tolstykh M. P. The problem of complex treatment of purulent wounds of various origins and trophic ulcers. Dissertation of the candidate of medical sciences. M. P. Tolstykh, M., 2002, pp. 42. (in Russ.)Толстых П.И., Тамразова О.Б., Павленко В.В., Кулешов И.Ю., Толстых М.П. Длительно не заживающие раны и язвы (патогенез, клиника, лечение) // Лазерная медицина. – 2009. – Т. 13(4). – С. 112–123.Tolstykh P. I., Tamrazova O. B., Pavlenko V. V. et al. Long-term nonhealing wounds and ulcers (pathogenesis, clinic, treatment). Laser medicine, 2009, Vol. 13 (4), pp. 112–123. (in Russ.)Sieber F., Brien J. et al. Antiviral activity of merocyanine 540 // Photochem. Photobiol. – 1987. – Vol. 46(5). – P. 707–711.Sieber F., Brien J. et al. Antiviral activity of merocyanine 540. Photochem. Photobiol, 1987, Vol. 46(5), pp. 707–711.Dukan S., Nustrom T. Oxidative stress defense and deterioration of growth-arrested Escherichia coli cells // J. Biol. Chem. – 1999. – Vol. 274(37). - P. 26027–26032.Dukan S., Nustrom T. Oxidative stress defense and deterioration of growth-arrested Escherichia coli cells. J. Biol. Chem, 1999, Vol. 274(37), pp. 26027–26032.Zugel U., Kaufmann S. Role of heat shock proteins in protection from and pathogenesis of infectious diseases // Clin. Microbiol. Rev. – 1999. – Vol. 12(1). – P. 19–39.Zugel U., Kaufmann S. Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin. Microbiol. Rev, 1999, Vol. 12(1), pp. 19–39.Komerik N., Wilson M., Poole S. The effect of photodynamic action on two virulence factors of gram-negative bacteria // Photochem. Photobiol. – 2000. – Vol. 72 (5). – P. 676–680.Komerik N., Wilson M., Poole S. The effect of photodynamic action on two virulence factors of gram-negative bacteria. Photochem. Photobiol, 2000, Vol. 72 (5), pp. 676–680.Packer S., Bhatti M., Burns T. et. al. // Lasers in medical Science. – 2000. – Vol. 15. – Iss. 1. – P. 24–30.Packer S., Bhatti M., Burns T. et. al. Lasers in medical Science, 2000, Vol. 15 (1), 24–30.Толстых П.И. , Соловьева А.Б. , Дербенев В.А., Спокойный А.Л., Аксенова Н.А. , Тимашев П.С. , Кузнецов Е.В. Берлин А.А., Осокин В.В. , Иванков М.П. Сравнительная эффективность лекарственных форм сенсибилизаторов // Лазерная медицина. – 2014. – Т. 18(2). – С. 8–12.Tolstykh P. I., Solov'eva A. B., Derbenev V. A. et al. A comparative effectiveness of various pharmaceutical forms of sensitizers applied in photodynamic therapy for purulent wounds. Laser medicine, 2014, Vol. 18 (2), pp. 8–12. (in Russ.)Гейниц А.В., Мустафаев Р.Д., Тихов Г.В., Кизевадзе Р.И. Фотодинамическая терапия в лечении перитонита (экспериментальное исследование) // Лазерная медицина. – 2012. – Т. 16 (2). – С. 58–62Geynitz A.V., Mustafajev R. D., Tikhov G. V., Kizevadze R. I. Photodynamic therapy in treating peritonitis (experimental study). Laser medicine, 2012, Vol. 16 (2), pp. 58–62. (in Russ.)Шубина А. М., Каплан М. А. Возможности фотодинамической терапии с использованием фотосенсибилизатора фотодитазин для лечения псориаза // Российский биотерапевтический журнал. – 2005. – Т.4 (3). – C. 76–79.Shubina a.m., Kaplan M. A. Potential of photodynamic therapy with the use of photosensitizer photoditazin for the treatment of psoriasis. Russian biotherapeutic journal, 2005, Vol. 4 (3), pp. 76–79. (in Russ.)Шишкина О.Е., Бутакова Л.Ю., Иванченко Ю.О., Антонов С.С. Микробиологическое обоснование эффективности фотосенсибилизаторов при фотодинамической терапии // Лазерная медицина. – 2013. – Т. 17(1). – С. 35–37.Shishkina O. E., Butakova L. Yu., Ivanchenko Yu. O., Antonov S. S. Microbiological backgrounding of photosensitizer effectiveness in photodynamic therapy. Laser medicine, 2013, Vol. 17 (1), pp. 35–37. (in Russ.)Carmello JC, Dovigo LN, Mima EG. et al. Correction: In vivo evaluation of photodynamic inactivation using Photodithazine against Candida albicans // Photochem Photobiol Sci. – 2017. – Vol.16 (8). – P. 1336–1337. doi: 10.1039/c7pp90027aCarmello JC, Dovigo LN, Mima EG. et al. Correction: In vivo evaluation of photodynamic inactivation using Photodithazine against Candida albicans. Photochem Photobiol Sci, 2017, Vol.16 (8), pp. 1336–1337. doi: 10.1039/c7pp90027aCarmello JC, Alves F, Mima EGO. et al. Corrigendum to "Photoinactivation of single and mixed biofilms of Candida albicans and non-albicans Candida species using Photodithazine // Photodiagn. Photodyn. Ther. – 2017. – Vol.17. – Р. 194–199.Carmello JC, Alves F, Mima EGO. et al. Corrigendum to "Photoinactivation of single and mixed biofilms of Candida albicans and non-albicans Candida species using Photodithazine. Photodiagn. Photodyn. Ther, 2017, Vol.17, pp. 194–199.Alves F, Carmello JC, Mima EGO. et al. Photodithazine-mediated antimicrobial photodynamic therapy against fluconazole-resistant Candida albicans in vivo // Medical Mycology – 2019. – Vol. 57(5). – P. 609–617Alves F, Carmello JC, Mima EGO. et al. Photodithazine-mediated antimicrobial photodynamic therapy against fluconazole-resistant Candida albicans in vivo. Medical Mycology, 2019, Vol. 57(5), pp. 609–617.Panariello BHD, Klein MI, Alves F. et al. DNase increases the efficacy of antimicrobial photodynamic therapy on Candida albicans biofilms // Photodiagnosis Photodyn Ther. – 2019. – Vol. 27. – Р. 124–130. doi: 10.1016/j.pdpdt.2019.05.038.Panariello BHD, Klein MI, Alves F. et al. DNase increases the efficacy of antimicrobial photodynamic therapy on Candida albicans biofilms. Photodiagnosis Photodyn Ther, 2019, Vol. 27, pp. 124–130. doi: 10.1016/j.pdpdt.2019.05.038.Janeth Rimachi Hidalgo K, Cabrini Carmello J, Carolina Jordão C. et al. Antimicrobial Photodynamic Therapy in Combination with Nystatin in the Treatment of Experimental Oral Candidiasis Induced by Candida albicans Resistant to Fluconazole // Pharmaceuticals (Basel, Switzerland). – 2019. – Vol. 12 (8). – Р. 140. doi: 10.3390/ph12030140.Janeth Rimachi Hidalgo K, Cabrini Carmello J, Carolina Jordão C. et al. Antimicrobial Photodynamic Therapy in Combination with Nystatin in the Treatment of Experimental Oral Candidiasis Induced by Candida albicans Resistant to Fluconazole. Pharmaceuticals (Basel, Switzerland), 2019, Vol. 12 (8), pp. 140. doi: 10.3390/ph12030140.Dovigo LN, Carmello JC, Carvalho MT. et al. Photodynamic inactivation of clinical isolates of Candida using Photodithazine // Biofouling. – 2013. – Vol. 29 – Р. - 1057–1067.Dovigo LN, Carmello JC, Carvalho MT. et al. Photodynamic inactivation of clinical isolates of Candida using Photodithazine. Biofouling, 2013, Vol. 29, pp. - 1057–1067.

The authors declare that there are no conflicts of interest present.