biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2021-10-2-42-50bioph-490Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCASE-REPORTSФотодинамическая терапия при раке кожи лица, развившегося в зоне предшествующей лучевой терапии (клиническое наблюдение)Photodynamic therapy for facial skin cancer developed in the zone of previous radiotherapy (clinical case)ФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

derkul23@yandex.ruГригорьевыхН. И.GrigoryevykhN. I.

Москва

Moscow

Иванова-РадкевичВ. И.Ivanova-RadkevichV. I.

Москва

Moscow

Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationРоссийский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation2021030820211024250Copyright © Филоненко Е.В., Григорьевых Н.И., Иванова-Радкевич В.И., 20212021Филоненко Е.В., Григорьевых Н.И., Иванова-Радкевич В.И.Filonenko E.V., Grigoryevykh N.I., Ivanova-Radkevich V.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/490

Приведены результаты 13-летнего клинического наблюдения пациентки после лечения базальноклеточного рака кожи правой щеки I ст сТ2N0M0. Анамнез заболевания связан с тем, что пациентке в раннем детстве по поводу гемангиомы нижнего века правого глаза и правой щеки выполнена лучевая терапия. В 2008 г., на фоне постлучевых изменений в области правой щеки, диагностирован базальноклеточный рак в МНИОИ им. П.А. Герцена. В Центре лазерной и фотодинамической диагностики и терапии опухолей пациентке проведено органосохраняющее лечение методом ФДТ. Проведен курс фотодинамической терапии (ФДТ) с 5-аминолевульновой кислотой. В последующем больная наблюдалась 13 лет без рецидива в зоне ФДТ. В 2016 г у пациентки диагностирован рецидив заболевания в виде нового очага базальноклеточного рака кожи верхнего века справа IА ст сТ1N0M0. Пациентке проведен курс ФДТ с фотосенсибилизатором на основе хлорина е6. Достигнута полная регрессия опухоли, срок безрецидивного наблюдения – 5 лет.

The results of a 13-year clinical observation of a patient after treatment for basal cell carcinoma of the skin of the right cheek Ist cT1N0M0 are presented. The history of the course of the disease is associated with the fact that the patient underwent radiation therapy in early childhood for hemangioma of the lower eyelid of the right eye and right cheek. In 2008, against the background of post-radiation changes in the area of the right cheek, basal cell carcinoma was diagnosed at the Moscow Oncological Research Institute. P.A. Herzen. At the Center for Laser and Photodynamic Diagnostics and Tumor Therapy, the patient underwent organ-preserving PDT treatment. A course of photodynamic therapy (PDT) with 5-aminolevulic acid was carried out. Subsequently, the patient was followed up until 2021 without relapse in the PDT area. In 2016, the patient was diagnosed with a relapse of the disease in the form of a new focus of basal cell carcinoma of the upper eyelid skin on the right Iast cT1N0M0. The patient underwent a course of PDT with a chlorin e6-based photosensitizer. Complete regression of the tumor was achieved, the period of relapse-free follow-up was 5 years.

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The authors declare that there are no conflicts of interest present.