biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2021-10-3-32-38bioph-503Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSВозможности фотодинамической терапии при лечении злокачественных опухолей полости ртаPossibilities of photodynamic therapy in the treatment of malignant tumors of the oral cavityПанасейкинЮ. А.PanaseykinY. A.

Обнинск

Obninsk

deus2@bk.ruФилоненкоЕ. В.FilonenkoE. V.

Обнинск

Obninsk

СеврюковФ. Е.SevrukovF. E.

Обнинск

Obninsk

КапинусВ. Н.KapinusV. N.

Обнинск

Obninsk

ПолькинВ. В.PolkinV. V.

Обнинск

Obninsk

ИсаевП. А.IsaevP. A.

Обнинск

Obninsk

КапринА. Д.KaprinA. D.

Обнинск

Obninsk

ИвановС. А.IvanovS. A.

Обнинск

Obninsk

МРНЦ им. А.Ф. Цыба – филиал ФГБУ «НМИЦ радиологии» МЗ РФРоссияA.Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological CenterRussian Federation2021281020211033238Copyright © Панасейкин Ю.А., Филоненко Е.В., Севрюков Ф.Е., Капинус В.Н., Полькин В.В., Исаев П.А., Каприн А.Д., Иванов С.А., 20212021Панасейкин Ю.А., Филоненко Е.В., Севрюков Ф.Е., Капинус В.Н., Полькин В.В., Исаев П.А., Каприн А.Д., Иванов С.А.Panaseykin Y.A., Filonenko E.V., Sevrukov F.E., Kapinus V.N., Polkin V.V., Isaev P.A., Kaprin A.D., Ivanov S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/503

Рак слизистой полости рта является распространенным заболеванием с относительно низкой выживаемостью. Стандартом лечения злокачественных новообразований (ЗНО) слизистой полости рта является хирургический метод, химио- и/или лучевая терапия. С внедрением современных протоколов и совершенствованием текущих методик лечения прирост выживаемости незначителен ввиду развития локарегионарных и отдаленных рецидивов, появления симультанных опухолей ротовой полости. Косметические и функциональные результаты у пациентов, перенесших комплексное лечение по поводу ЗНО полости рта, зачастую бывают неудовлетворительными. Очевидна необходимость разработки новых подходов лечения пациентов со ЗНО слизистой полости рта. Подобными свойствами обладает фотодинамическая терапия (ФДТ). С развитием эндоскопической и оптико-волоконной аппаратуры области применения ФДТ значительно расширились. Стали доступны для воздействия ФДТ очаги в области ротовой полости и рото-гортаноглотке. Начальные стадии рака слизистой ротовой полости оптимально подходят для применения ФДТ, ввиду того что могут быть обработаны обширные поверхностные дефекты с минимальными осложнениями. Сохранение субэпителиальных и коллагеновых структур, что характерно для ФДТ, способствует заживлению без образования рубцовых процессов, благодаря чему достигается идеальный косметический и функциональный эффект. Применение ФДТ при лечении рака полости рта не ограничивается только начальными стадиями в самостоятельном варианте. Возможно применение ФДТ в комбинации с хирургическим и лучевым методом лечения. При массивных опухолевых процессах ФДТ применяется с паллиативной целью. Изучается влияние адаптивного иммунного ответа под воздействием ФДТ.

Oral mucosa cancer is a common disease with relatively low survival rates. The standard for the treatment of malignant neoplasms (MNO) of the oral mucosa is the surgical method, chemotherapy and / or radiation therapy. With the introduction of modern protocols and the improvement of current treatment methods, the increase in survival is insignificant due to the development of local and distant relapses, the appearance of simultaneous tumors of the oral cavity. Cosmetic and functional results in patients who have undergone complex treatment for oral cancer are often unsatisfactory. There is an obvious need to develop new approaches to treating patients with cancer of the oral mucosa. Photodynamic therapy (PDT) has similar properties. With the development of endoscopic and fiber-optic equipment, the fields of PDT application have significantly expanded. Foci in the oral cavity and oropharynx became available for PDT. The early stages of oral mucosal cancer are optimal for PDT because large surface defects can be treated with minimal complications. Preservation of subepithelial and collagen structures, which is typical for PDT, promotes healing without the formation of scar processes, thereby achieving an ideal cosmetic and functional effect. The use of PDT in the treatment of oral cavity cancer is not limited only to the initial stages in an independent version. It is possible to use PDT in combination with surgical and radiation treatment. In case of massive tumor processes, PDT is used for palliative purposes. The influence of the adaptive immune response under the influence of PDT is being studied.

фотодинамическая терапияплоскоклеточный рак полости ртадисплазияпредракорганосохранное лечение рака полости ртаphotodynamic therapysquamous cell carcinoma of the oral cavitydysplasiaprecancerorgan-preserving treatment of oral cancerReferencesFerlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D. M., Forman D., Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in Globoscan 2012//Int. J. Cancer. – 2015. – Vol. 136. – Р. 359–386.Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D. M., Forman D., Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in Globoscan 2012. Int. J. Cancer, 2015, Vol. 136, pp. 359–386.Каприн А. Д., Старинский В. В., Петров Г. В. Злокачественные новообразования в России в 2015 году. (заболеваемость и смертность) МНИОИ им. П. А. Герцена – филиал ФГБУ «НМИЦ Радиологии» Минздрава России. – 2017. – С. 11.Kaprin A. D., Starinsky V. V., Petrov G. V. Malignant neoplasms in Russia in 2015. (morbidity and mortality) of the P. A. MNIOI after P. A. Herzen a brach of the federal State Budgetary Institution «NMIRTS» of the Russia Federation Publ, 2017, p. 11. (in Russian)Hicks W. L., Loree T. R., Garcia R. I., et al. Squamous cell carcinoma of the floor of mouth: a 20-year review//Head Neck. – 1997. – Vol. 19 (5). – P. 400–405.Hicks W. L., Loree T. R., Garcia R. I., et al. Squamous cell carcinoma of the floor of mouth: a 20-year review. Head Neck, 1997, Vol. 19 (5), рр. 400–405.Wang B., Zhang S., Yue K., Wang X. D. The recurrence and survival of oral squamous cell carcinoma: A report of 275 cases//Chin. J. Cancer. – 2013. – Vol. 32. – Р. 614–618.Wang B., Zhang S., Yue K., Wang X. D. The recurrence and survival of oral squamous cell carcinoma: A report of 275 cases. Chin. J. Cancer, 2013, Vol. 32, рр. 614–618.Шинкарев С. А., Болдырев С. В., Загадаев А. П., Подольский В. Н., Борисов В. А., Костюшина Ю. И. Антимикробная фотодинамическая терапия в голосовой реабилитации пациентов после ларингэктомии//Biomedical Photonics. – 2021. – Т. 10, № 1. – С. 11–16. https://doi.org/10.24931/2413–9432–2021–10–1-11–16Shinkarev S. A., Boldyrev S. V., Zagadaev A. P., Podolsky V. N., Borisov V. A., Kostyushina Yu. I. Antimicrobial photodynamic therapy in voice rehabilitation of patients after laryngectomy. Biomedical Photonics, 2021, Vol. 10 (1), рр. 11–16. https://doi.org/10.24931/2413–9432–2021–10–1-11–16 (in Russian)Sokolov V. V., Chissov V. I., Filonenko E. V., Kozlov D. N., Smirnov V. V. Photodynamic therapy of cancer with the photosensitizer PHOTOGEM//Proceedings of SPIE – The International Society for Optical Engineering. – 1995. – Vol. 2325. – Р. 367–374.Sokolov V. V., Chissov V. I., Filonenko E. V., Kozlov D. N., Smirnov V. V. Photodynamic therapy of cancer with the photosensitizer PHOTOGEM. Proceedings of SPIE – The International Society for Optical Engineering, 1995, Vol. 2325, рр. 367–374.Filonenko E. V. The history of development of fluorescence diagnosis and photodynamic therapy and their capabilities in oncology//Russian Journal of General Chemistry. – 2015. – Vol. 85 (1). – Р. 211–216.Filonenko E. V. The history of development of fluorescence diagnosis and photodynamic therapy and their capabilities in oncology. Russian Journal of General Chemistry, 2015, Vol. 85 (1), рр. 211–216.Sokolov V. V., Filonenko E. V., Telegina L. V., Boulgakova N. N., Smirnov V. V. Combination of fluorescence imaging and local spectrophotometry in fluorescence diagnostics of early cancer of larynx and bronchi//Quantum Electronics. – 2002. – Vol. 32 (11). – Р. 963–969.Sokolov V. V., Filonenko E. V., Telegina L. V., Boulgakova N. N., Smirnov V. V. Combination of fluorescence imaging and local spectrophotometry in fluorescence diagnostics of early cancer of larynx and bronchi. Quantum Electronics, 2002, Vol. 32 (11), рр. 963–969.Filonenko E. V., Kozlov D. N., Smirnov V. V. First clinical results with a new drug for PDT//Proceedings of SPIE – The International Society for Optical Engineering. – 1995. – Vol. 2325. – Р. 364–366.Filonenko E. V., Kozlov D. N., Smirnov V. V. First clinical results with a new drug for PDT. Proceedings of SPIE – The International Society for Optical Engineering, 1995, Vol. 2325, рр. 364–366.Verrico A. K., Haylett A. K., Moore J. V. In vivo expression of the collagen-related heat shock protein HSP47, following hyperthermia or photodynamic therapy//Lasers Med. Sci. – 2001. – Vol. 16. – Р. 192–198.Verrico A. K., Haylett A. K., Moore J. V. In vivo expression of the collagen-related heat shock protein HSP47, following hyperthermia or photodynamic therapy. Lasers Med. Sci, 2001, Vol. 16, рр. 192–198.Филоненко Е. В. Диссертация на соискание степени доктора медицинских наук на тему «Флюоресцентная диагностика и фотодинамическая терапия в онкологии».Filonenko E. V. Dissertation for the degree of Doctor of Medical Sciences on the topic «Fluorescent diagnostics and photodynamic therapy in oncology». (in Russian)Grossweiner L. I., Hill J. H., Lobraico R. V. Photodynamic therapy of head and neck squamous cell carcinoma: Optical dosimetry and clinical trial//Photochem. Photobiol. –1987. – Vol. 46. – Р. 911–917.Grossweiner L. I., Hill J. H., Lobraico R. V. Photodynamic therapy of head and neck squamous cell carcinoma: Optical dosimetry and clinical trial. Photochem. Photobiol, 1987, Vol. 46, рр. 911–917.Gluckman J. L. Hematoporphyrin photodynamic therapy: Is there truly a future in head and neck oncology? Reflections on a 5-year experience//Laryngoscope. – 1991– Vol. 101. – Р. 36–42.Gluckman J. L. Hematoporphyrin photodynamic therapy: Is there truly a future in head and neck oncology? Reflections on a 5-year experience. Laryngoscope, 1991, Vol. 101, рр. 36–42.Fan K. F., Hopper C., Speight P. M., Buonaccorsi G., MacRobert A. J., Bown S. G. Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity//Cancer. – 1996 – Vol. 78. – Р. 1374–1383.Fan K. F., Hopper C., Speight P. M., Buonaccorsi G., MacRobert A. J., Bown S. G. Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity. Cancer, 1996, Vol. 78, рр. 1374–1383.Fan K. F., Hopper C., Speight P. M., Buonaccorsi G. A., Bown S. G. Photodynamic therapy using mTHPC for malignant disease in the oral cavity//Int. J. Cancer. – 1997– Vol. 73. – Р. 25–32.Fan K. F., Hopper C., Speight P. M., Buonaccorsi G. A., Bown S. G. Photodynamic therapy using mTHPC for malignant disease in the oral cavity. Int. J. Cancer, 1997, Vol. 73, рр. 25–32.Hopper C. Photodynamic therapy with Foscan (temoporfin) in primary squamous cell carcinoma of the head and neck//Proceedings Fifth International Congress on Head and Neck Oncology; San Francisco, USA. July. – 2000.Hopper C. Photodynamic therapy with Foscan (temoporfin) in primary squamous cell carcinoma of the head and neck. Proceedings Fifth International Congress on Head and Neck Oncology; San Francisco, USA. July. – 2000.Biel M. A. Photodynamic therapy of head and neck cancers//Methods Mol. Biol. – 2010. – Vol. 635. – Р. 281–293.Biel M. A. Photodynamic therapy of head and neck cancers. Methods Mol. Biol, 2010, Vol. 635, рр. 281–293.Полькин В. В. диссертация «Фотодинамическая терапия с фотосенсибилизатором «Фотолон» в самостоятельном и комплексном лечении рака слизистой оболочки полости рта». – 2011.Polkin V. V. dissertation «Photodynamic therapy with «Photolon» photosensitizer in the independent and complex treatment of cancer of the oral mucosa», 2011. (in Russian)Sebastiaan A. H., De Visscher S. A., Melchers L. J., Dijkstra P. U., Karakullukcu B., Tan I. B., Hopper C., Roodenburg J. L., Witjes M. J. Mthpc-mediated photodynamic therapy of early stage oral squamous cell carcinoma: A comparison to surgical treatment//Ann. Surg. Oncol. – 2013. – Vol. 20. – Р. 3076–3082.Sebastiaan A. H., De Visscher S. A., Melchers L. J., Dijkstra P. U., Karakullukcu B., Tan I. B., Hopper C., Roodenburg J. L., Witjes M. J. Mthpc-mediated photodynamic therapy of earlystage oral squamous cell carcinoma: A comparison to surgical treatment. Ann. Surg. Oncol, 2013, Vol. 20, рр. 3076–3082.Cerrati E. W., Nguyen S. A., Farrar J. D., Lentsch E. J. The efficacy of photodynamic therapy in the treatment of oral squamous cell carcinoma: A meta-analysis//Ear Nose Throat J. – 2015. – Vol. 94. – Р. 72–79.Cerrati E. W., Nguyen S. A., Farrar J. D., Lentsch E. J. The efficacy of photodynamic therapy in the treatment of oral squamous cell carcinoma: A meta-analysis. Ear Nose Throat J, 2015, Vol. 94, рр. 72–79.Allison R. R., Sibata, C., Gay H. Pdt for cancers of the head and neck//Photodiagn. Photodyn. Ther. – 2009. – Vol. 6. – Р. 1–2.Allison R. R., Sibata, C., Gay H. Pdt for cancers of the head and neck. Photodiagn. Photodyn. Ther, 2009, Vol. 6, рр. 1–2.Chen W., Zhang, J. Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment. J. Nanosci. Nanotechnol. – 2006. – Vol. 6. – Р. 1159–1166.Chen W., Zhang, J. Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment. J. Nanosci. Nanotechnol, 2006, Vol. 6, рр. 1159–1166.Huang Z. A Review of Progress in Clinical Photodynamic Therapy//Technol. Cancer Res. Treat. – 2005. – Vol. 4, № 3. – P. 283–293.Huang Z. A Review of Progress in Clinical Photodynamic Therapy. Technol. Cancer Res. Treat, 2005, Vol. 4 (3), рр. 283–293.Canti G., Lattuada D., Nicolin A. Э., Taroni P., Valentini G., Cubeddu R. Antitumor immunity induced by photodynamic therapy with aluminum disulfonated phthalocyanines and laser light//Anticancer Drugs. – 1994. – Vol. 5. – P. 443–447.Canti G., Lattuada D., Nicolin A. Э., Taroni P., Valentini G., Cubeddu R. Antitumor immunity induced by photodynamic therapy with aluminum disulfonated phthalocyanines and laser light. Anticancer Drugs, 1994, Vol. 5, рр. 443–447.Solban N., Rizvi I., Hasan, T. Targeted photodynamic therapy//Lasers Surg. Med. – 2006. – Vol. 38. – P. 522–531.Solban N., Rizvi I., Hasan, T. Targeted photodynamic therapy. Lasers Surg. Med, 2006, Vol. 38, рр. 522–531.Staneloudi C., Smith K. A., Hudson R., Malatesti N., Savoie H., Boyle R. W., Greenman J. Development and characterization of novel photosensitizer: SCFV conjugates for use in photodynamic therapy of cancer//Immunology. – 2007. – Vol. 120. – P. 512–517.Staneloudi C., Smith K. A., Hudson R., Malatesti N., Savoie H., Boyle R. W., Greenman J. Development and characterization of novel photosensitizer: SCFV conjugates for use in photodynamic therapy of cancer. Immunology, 2007, Vol. 120, рр. 512–517.Starkey J. R., Rebane A. K., Drobizhev M. A., Meng F., Gong A., Elliott A., McInnerney K., Spangler C. W. New two-photon activated photodynamic therapy sensitizers induce xenograft tumor regressions after near-IR laser treatment through the body of the host mouse//Clin. Cancer Res. – 2008. – Vol. 14. – P. 6564–6573.Starkey J. R., Rebane A. K., Drobizhev M. A., Meng F., Gong A., Elliott A., McInnerney K., Spangler C. W. New two-photon activated photodynamic therapy sensitizers induce xenograft tumor regressions after near-IR laser treatment through the body of the host mouse. Clin. Cancer Res, 2008, Vol. 14, рр. 6564–6573.Brown, S. Photodynamic therapy: Two photons are better than one//Nat. Photon. – 2008. – Vol. 2. – P. 394–395.Brown, S. Photodynamic therapy: Two photons are better than one. Nat. Photon, 2008, Vol. 2, рр. 394–395.

The authors declare that there are no conflicts of interest present.