biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2021-10-4-23-34bioph-515Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИсследование процессов передачи энергии между редкоземельными ионами и молекулами фотосенсибилизаторов для задач фотодинамической терапии с возбуждением в ИК-диапазонеStudy of energy transfer processes between rare earth ions and photosensitizer molecules for photodynamic therapy with IR-excitationПоминоваД. В.PominovaD. V.

Москва

Moscow

pominovadv@gmail.comБогатоваА. С.BogatovaA. S.

Москва

Moscow

ПройдаковаВ. Ю.ProydakovaV. Y.

Москва

Moscow

РоманишкинИ. Д.RomanishkinI. D.

Москва

Moscow

АхлюстинаЕ. В.AkhlyustinaE. V.

Москва

Moscow

КузнецовС. В.KuznetsovS. V.

Москва

Moscow

СавельеваТ. А.SavelevaT. A.

Москва

Moscow

ЛукьянецЕ. А.LukyanetsE. A.

Москва

Moscow

ЛощеновВ. Б.LoschenovV. B.

Москва

Moscow

Институт общей физики им. А.М. Прохорова Российской академии наук; НИЯУ МИФИРоссияProkhorov General Physics Institute of the Russian Academy of Sciences; National research nuclear university MEPHIRussian FederationНИЯУ МИФИРоссияNational research nuclear university MEPHIRussian FederationИнститут общей физики им. А.М. Прохорова Российской академии наукРоссияProkhorov General Physics Institute of the Russian Academy of SciencesRussian FederationООО «Биоспек»РоссияBiospecRussian Federation2021040220221042334Copyright © Поминова Д.В., Богатова А.С., Пройдакова В.Ю., Романишкин И.Д., Ахлюстина Е.В., Кузнецов С.В., Савельева Т.А., Лукьянец Е.А., Лощенов В.Б., 20222022Поминова Д.В., Богатова А.С., Пройдакова В.Ю., Романишкин И.Д., Ахлюстина Е.В., Кузнецов С.В., Савельева Т.А., Лукьянец Е.А., Лощенов В.Б.Pominova D.V., Bogatova A.S., Proydakova V.Y., Romanishkin I.D., Akhlyustina E.V., Kuznetsov S.V., Saveleva T.A., Lukyanets E.A., Loschenov V.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/515

На сегодняшний день фотодинамическая терапия (ФДТ) является одним из самых перспективных минимально инвазивных методов лечения различных заболеваний, включая злокачественные новообразования. Основным ограничением применения этой методики является недостаточная проникающая способность в ткань лазерного излучения, используемого для активации молекул фотосенсибилизатора (ФС), что затрудняет проведение терапии при лечении объемных или глубокозалегающих опухолей. В связи с этим наблюдается большой интерес к разработке новых стратегий ФДТ с использованием для возбуждения инфракрасного (ИК) излучения, длины волн которого попадают в «окно прозрачности» биологических тканей. В работе было предложено использовать ап-конверсионные наночастицы (АКНЧ) NaGdF4 :Yb:Er, которые поглощают инфракрасное возбуждение и служат донором, передающим энергию ФС. В качестве наиболее перспективных ФС для исследования были выбраны фотосенс и фталосенс. Исследованы процессы передачи энергии между АКНЧ, легированными редкоземельными ионами, и молекулами ФС для верификации возможности возбуждения ФС ИК-излучением и проведения ФДТ глубокозалегающих новообразований. При помощи спектроскопических и время-разрешенных методов продемонстрировано, что наблюдается эффективная передача энергии между АКНЧ и ФС фталосенс и фотосенс. Расчётная эффективность передачи энергии по механизму Фёрстера составила 41% для системы АКНЧ + фотосенс и 69% для АКНЧ + фталосенс. Экспериментально и теоретически доказано, что наблюдается связывание молекул ФС с АКНЧ посредством поверхностно-активного вещества, приводящее к сокращению расстояния между ними, за счет чего реализуется эффективная безызлучательная передача энергии. Продемонстрирована генерация синглетного кислорода молекулами фталосенса при возбуждении посредством передачи энергии от АКНЧ, возбуждаемых длиной волны 980 нм.

Today, photodynamic therapy is one of the most promising minimally invasive methods of treatment of various diseases, including cancer. The main limitation of this method is the insufficient penetration into the tissue of laser radiation used to activate photosensitizer molecules, which makes it difficult to carry out therapy in the treatment of large or deep-seated tumors. In this regard, there is a great interest in the development of new strategies for photodynamic therapy using infrared radiation for excitation, the wavelengths of which fall into the “transparency window” of biological tissues. In this work, it was proposed to use upconversion NaGdF4 :Yb:Er nanoparticles (UCNP), which absorb infrared excitation and serve as a donor that transfers energy to the photosensitizer. Photosens and phthalosens were chosen as the most promising photosensitizers for the study. The aim of this work was to study the energy transfer processes between upconversion nanoparticles doped with rare-earth ions and photosensitizer molecules. in order to excite photosensitizers with IR radiation and carry out photodynamic therapy of deep-seated neoplasms. Using spectroscopic and time-resolved methods, it has been demonstrated that there is an efficient energy transfer between upconversion particles and photosensitizers phthalosens and photosens. The calculated efficiency of energy transfer by the Foerster mechanism was 41% for the UCNP + photosens system and 69% for the UCNP + phthalosens system. It has been experimentally and theoretically proved that there is a binding of photosensitizer molecules with UCNP by means of surfactants, leading to a reduction in the distance between them, due to which effective nonradiative energy transfer is realized. The generation of singlet oxygen by the phthalosens photosensitizer upon excitation by means of energy transfer from UCNP, excited at 980 nm wavelength of, has been demonstrated.

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The authors declare that there are no conflicts of interest present.