References

bioph

Biomedical Photonics

2413-9432

Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis

10.24931/2413-9432-2021-10-4-44-58

bioph-518

Research Article

ОРИГИНАЛЬНЫЕ СТАТЬИ

ORIGINAL ARTICLES

Фотоиндуцированные процессы наночастиц оксида железа для усиления лазерной терапии

Photo-induced processes of iron oxide nanoparticles to enhance laser therapy

Поминова

Д. В.

Pominova

D. V.

Москва

Moscow

Романишкин

И. Д.

Romanishkin

I. D.

Москва

Moscow

Плотникова

Е. А.

Plotnikova

E. A.

Москва

Moscow

Морозова

Н. Б.

Morozova

N. B.

Москва

Moscow

Лощенов

В. Б.

Loschenov

V. B.

Москва

Wittig

Ульм

Ulm

Linden

Ульм

Ulm

Steiner

R. W.

Steiner

R. W.

Москва

Moscow

Рябова

А. В.

Ryabova

A. V.

Москва

Moscow

nastya.ryabova@gmail.com

Институт общей физики им. А.М. Прохорова Российской академии наук; Национальный исследовательский ядерный университет «МИФИ»РоссияProkhorov General Physics Institute of the Russian Academy of Sciences; National Research Nuclear University «MEPhI»Russian Federation

Институт общей физики им. А.М. Прохорова Российской академии наукРоссияProkhorov General Physics Institute of the Russian Academy of SciencesRussian Federation

Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian Federation

Институт лазерных технологий в медицине и метрологииГерманияInstitute for Laser Technologies in Medicine & MetrologyGermany

Институт неорганической химии II Университета г. УльмГерманияInstitute for Inorganic Chemistry II at Ulm UniversityGermany

Национальный исследовательский ядерный университет «МИФИ»РоссияNational Research Nuclear University «MEPhI»Russian Federation

2021

05022022

1044458

2022

Поминова Д.В., Романишкин И.Д., Плотникова Е.А., Морозова Н.Б., Лощенов В.Б., Wittig R., Linden M., Steiner R.W., Рябова А.В.

Pominova D.V., Romanishkin I.D., Plotnikova E.A., Morozova N.B., Loschenov V.B., Wittig R., Linden M., Steiner R.W., Ryabova A.V.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pdt-journal.com/jour/article/view/518

Наночастицы используются в качестве носителей лекарственных средств для повышения селективности и эффективности терапии, а также для сочетанной терапии, объединяющей разные виды воздействия. Перспективными в этом аспекте являются наночастицы оксида железа. Благодаря магнитным свойствам, они могут быть применяться в качестве контраста для магнитно-резонансной томографии. Также наночастицы оксида железа могут быть покрыты фотосенсибилизатором для фотодинамической терапии, а их лазерный или магнитный нагрев этих частиц может используется для проведения фототерапии. При этом локальное усиление электромагнитного поля вблизи наночастиц оксида железа может повысить интенсивность флуоресценции фотосенсибилизаторов и эффективность генерации синглетного кислорода.

В работе представлены результаты исследования наночастиц оксида железа, сфокусированного на фотофизических аспектах образования «горячих точек» при лазерном облучении. Фотоиндуцированные эффекты наночастиц оксида железа, наблюдаемые в экспериментах in vitro, приводят к разрыву лизосом. Теоретическое моделирование показало, что нагрев наночастиц оксида железа радиусом 35 нм под действием лазерного излучения составляет порядка 89˚С и 19˚С для длин волн 458 и 561 нм, соответственно. Локальное усиление поля возникает в парах из наночастиц различного размера и сильно зависит от расстояния между ними. Максимальное усиление достигается при малых расстояниях между наночастицами. Для димера наночастиц с радиусами 10 нм и 35 нм на расстоянии 1 нм получен фактор усиления на два порядка. Рассмотренное явление «горячих точек» востребовано для прецизионной терапии, так как фотоиндуцированные процессы возникают на малых расстояниях между наночастицами, в областях с их высоким накоплением.

Nanoparticles are used as drug carriers to increase the selectivity and effectiveness of therapy, as well as for combined therapy that utilizes different effects. Iron oxide nanoparticles are promising in this aspect. Due to magnetic properties, they can be used as a contrast agent for magnetic resonance imaging. Also, iron oxide nanoparticles could be coated with a photosensitizer for photodynamic therapy and their laser or magnetic heating can be used for phototherapy. Local enhancement of the electromagnetic field near iron oxide nanoparticles can increase the fluorescence intensity of photosensitizers and the efficiency of singlet oxygen generation. This paper presents the results of a study of iron oxide nanoparticles focused on the photophysical aspects of the formation of “hot spots” under laser irradiation. The photoinduced effects of iron oxide nanoparticles observed in in vitro experiments lead to the rupture of lysosomes. Theoretical modeling showed that the heating of iron oxide nanoparticles with a radius of 35 nm under the action of laser radiation is about 89°C and 19°C for wavelengths of 458 and 561 nm, respectively. Local field enhancement occurs in pairs of nanoparticles of various sizes and strongly depends on the distance between them. The maximum gain is achieved at small distances between nanoparticles. For a dimer of nanoparticles with radii of 10 and 35 nm at a distance of 1 nm, an enhancement factor of two orders of magnitude was obtained. The investigated phenomenon of «hot spots» is in demand for precision therapy, because the photo-induced processes occur at small distances between nanoparticles, in areas of their high accumulation.

наночастицы оксида железаплазмон-поляритоны«горячие точки»моделированиелазерная гипертермияусиление электромагнитного поля

Iron oxide nanoparticlesplasmon polaritons«hot spots»modelinglaser hyperthermiaelectromagnetic field amplification

Работа выполнена при финансовой поддержке РФФИ, грант 21–52–12030 ННИО_а.

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The authors declare that there are no conflicts of interest present.