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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bioph</journal-id><journal-title-group><journal-title xml:lang="ru">Biomedical Photonics</journal-title><trans-title-group xml:lang="en"><trans-title>Biomedical Photonics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2413-9432</issn><publisher><publisher-name>Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24931/2413-9432-2022-11-1-27-36</article-id><article-id custom-type="elpub" pub-id-type="custom">bioph-532</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Фотодинамическая терапия в лечении больных грибовидным микозом</article-title><trans-title-group xml:lang="en"><trans-title>Photodynamic therapy in the treatment of patients with mycosis fungoides</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филоненко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Filonenko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">derkul23@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова-Радкевич</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova-Radkevich</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Российский Университет дружбы народов<country>Россия</country></aff><aff xml:lang="en">Peoples’ Friendship University of Russia (RUDN University)<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>25</day><month>05</month><year>2022</year></pub-date><volume>11</volume><issue>1</issue><fpage>27</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Филоненко Е.В., Иванова-Радкевич В.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Филоненко Е.В., Иванова-Радкевич В.И.</copyright-holder><copyright-holder xml:lang="en">Filonenko E.V., Ivanova-Radkevich V.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pdt-journal.com/jour/article/view/532">https://www.pdt-journal.com/jour/article/view/532</self-uri><abstract><p>В обзоре освещены современные представления об эпидемиологии, этиологии, патогенезе, существующих классификациях грибовидного микоза. Описаны методы диагностики и лечения патологии, важную роль среди которых играет фотодинамическая терапия (ФДТ). К основным преимуществам ФДТ грибовидного микоза относятся отсутствие системной токсичности, неинвазивность, избирательность действия, отсутствие канцерогенного потенциала, возможность проведения повторных курсов лечения и хорошие косметические результаты. В настоящем обзоре собраны и проанализированы результаты клинических исследований ФДТ пациентов с грибовидным микозом. Анализ показал высокую эффективность ФДТ у пациентов с грибовидным микозом с изолированными или ограниченными пятнами и бляшками. ФДТ можно рассматривать как терапию выбора у пациентов с очагами на лице, когда одним из основных требований является хороший косметический результат, а лучевая терапия, азотный иприт или кармустин могут оставить постоянные и видимые шрамы. Бляшки, расположенные в подмышечных или паховых складках кожи, недоступные для фототерапии, также можно лечить с помощью ФДТ.</p></abstract><trans-abstract xml:lang="en"><p>The review highlights the current understanding of the epidemiology, etiology, pathogenesis, existing classifications of mycosis fungoides. Methods for diagnosis and treatment of the pathology are described, among which photodynamic therapy (PDT) plays an important role. The main advantages of PDT for mycosis fungoides include the absence of systemic toxicity, non-invasiveness, selectivity, absence of carcinogenic potential, the possibility of repeated courses of treatment, and good cosmetic results. This review collects and analyzes the results of clinical trials of PDT in patients with mycosis fungoides. The analysis showed high efficiency of PDT in patients with mycosis fungoides with isolated or limited spots and plaques. PDT can be considered as the therapy of choice in patients with facial lesions when a good cosmetic result is one of the main requirements, and radiation therapy, nitrogen mustard or carmustine can leave permanent and visible scars. Plaques located in the axillary or inguinal skin folds that are inaccessible to phototherapy can also be treated with PDT.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фотодинамическая терапия</kwd><kwd>грибовидный микоз</kwd><kwd>5-аминолевулиновая кислота</kwd></kwd-group><kwd-group xml:lang="en"><kwd>photodynamic therapy</kwd><kwd>mycosis fungoides</kwd><kwd>5-aminolevulinic acid</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Larocca C., Kupper T., Mycosis Fungoides and Sézary Syndrome // Hematol Oncol Clin North Am. – 2019. – Vol. 33(1). – P.103-120. doi: 10.1016/j.hoc.2018.09.001</mixed-citation><mixed-citation xml:lang="en">Larocca C., Kupper T., Mycosis Fungoides and Sézary Syndrome // Hematol Oncol Clin North Am. – 2019. – Vol. 33(1). – P.103-120. doi: 10.1016/j.hoc.2018.09.001</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Keehn C.A., Belongie I.P., Shistik G. et al. 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