References

bioph

Biomedical Photonics

2413-9432

Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis

10.24931/2413-9432-2022-11-1-37-48

bioph-533

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEWS

Актинический кератоз (обзор литературы)

Actinic keratosis (review of literature)

Филоненко

Е. В.

Filonenko

E. V.

Москва

Moscow

derkul23@yandex.ru

Окушко

С. С.

Okushko

S. S.

Москва

Moscow

«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian Federation

«Государственный научный центр лазерной медицины им. О.К. Скобелкина ФМБА»РоссияThe Federal State-Financed Institution Skobelkin State Scientific Center of Laser Medicine under the Federal Medical Biological AgencyRussian Federation

2022

25052022

1113748

2022

Филоненко Е.В., Окушко С.С.

Filonenko E.V., Okushko S.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pdt-journal.com/jour/article/view/533

Актинический кератоз (АК) рассматривается как предраковое состояние, ассоциированное с повышенным, в случаях отсутствия лечения до 20%, риском развития плоскоклеточного рака кожи. По мере дальнейшего развития технологий ранней диагностики онкологических заболеваний, в том числе и рака кожи, увеличения продолжительности жизни людей и популяризации путешествий в экзотические страны, число случаев АК среди населения будет возрастать. В этой связи информирование медицинского сообщества о причинах и патогенезе заболевания, разнообразии клинической картины АК, методах неинвазивной диагностики и лечения представляется важной медико-социальной задачей. Каждый из диагностических и терапевтических методов имеет свои преимущества и недостатки, поэтому, руководствуясь данными доказательной медицины, важно персонифицировать подходы к диагностике и лечению для каждого конкретного пациента. Более того, после лечения АК часто возникают рецидивы, которые являются следствием недостаточной диагностики и выработки неправильной тактики лечения. В обзорной статье приводятся клиническая картина АК, сравнительная характеристика диагностических и лечебных методов с позиций эффективности и безопасности применения у пациентов с АК.

Actinic keratosis is an important medical and social problem, the correct diagnosis and treatment of which will help to avoid the development of invasive forms of cutaneous squamous cell carcinoma. With the further development of the early diagnosis of cancer, including skin cancer, the increase in human life expectancy, and the popularization of travel to exotic countries, the number of cases of actinic keratosis among the population will continue to grow. In this regard, it is important to discuss the causes and pathogenesis of the disease, the varied clinical picture of the disease, methods of non-invasive diagnostics, as well as methods of treatment, of which there are a great many in the treatment of actinic keratosis today. However, each of the methods has both advantages and disadvantages, and in the global trend towards a personalized approach to treatment, it is important to choose from the standpoint of evidence-based medicine the most suitable for each individual patient. Moreover, after treatment of actinic keratosis, relapses often occur, which are the result of insufficient diagnosis and the development of incorrect treatment tactics. The review article provides the clinical picture of actinic keratosis, diagnostic and therapeutic methods, and their comparison with each other in terms of efficacy and safety

актинический кератозплоскоклеточный рак кожи in situфотодинамическая терапия

actinic keratosiscutaneous squamous cell carcinoma in situphotodynamic therapy

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The authors declare that there are no conflicts of interest present.