References

bioph

Biomedical Photonics

2413-9432

Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis

10.24931/2413-9432-2022-11-3-24-34

bioph-551

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEWS

Фотодинамическая терапия в лечении экстрамаммарного рака педжета

Photodynamic therapy in the treatment of extramammary paget’s disease

Филоненко

Е. В.

Filonenko

E. V.

derkul23@yandex.ru

Иванова-Радкевич

В. И.

Ivanova-Radkevich

«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian Federation

Российский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation

2022

15112022

1132434

2022

Филоненко Е.В., Иванова-Радкевич В.И.

Filonenko E.V., Ivanova-Radkevich V.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pdt-journal.com/jour/article/view/551

Экстрамаммарный рак Педжета (ЭМРП) – редко встречающаяся опухоль, которая преимущественно поражает кожу, содержащую апокринные железы. Из-за недостаточного количества данных по эффективности разных методов отсутствует единый терапевтический подход к лечению пациентов с ЭМРП и их последующего ведения. Применение хирургических методов, лазерной терапии и местных цитостатических препаратов имеет ряд ограничений. Преимуществами использования при ЭМРП фотодинамической терапии (ФДТ) являются отсутствие системной токсичности, неинвазивность, избирательность действия, отсутствие канцерогенного потенциала, возможность проведения нескольких курсов лечения и хорошие косметические результаты. В нашем обзоре проанализированы опубликованные в 2000-2022 гг. данные о результатах лечения методом ФДТ 114 пациентов с ЭМРП. В результате лечения полная регрессия опухолевых очагов была достигнута у 40% пациентов. Большинство авторов отмечают, что ФДТ эффективнее при очагах небольшой площади (до 4 см2).

Extramammary Paget’s disease (EMPD) is a rare tumor that predominantly affects the skin containing apocrine glands. Due to insufficient data on the effectiveness of different methods, there is no single therapeutic approach to the treatment of patients with EMPD and their subsequent management. The use of surgical methods, laser therapy and local cytotoxic drugs has a number of limitations. The advantages of using photodynamic therapy (PDT) in EMPD are the absence of systemic toxicity, non-invasiveness, selectivity of action, the absence of carcinogenic potential, the possibility of conducting several courses of treatment, and good cosmetic results. In our review, we analyzed those published in 2000-2022 data on the results of PDT treatment of 114 patients with EMPD. As a result of treatment, complete regression of tumor foci was achieved in 40% of patients. Most authors note that PDT is more effective for small areas (up to 4 cm2).

фотодинамическая терапияэкстрамаммарный рак Педжета5-аминолевулиновая кислотафотофринметиловый эфир 5-аминолевулиновой кислоты

photodynamic therapyextramammary Paget’s disease5-aminolevulinic acidphotofrin5-aminolevulinic acid methyl ester

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The authors declare that there are no conflicts of interest present.