biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2022-11-3-40-44bioph-553Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCASE-REPORTSФотодинамическая терапия больной с впч–ассоциированной lsil шейки матки (клиническое наблюдение)Photodynamic therapy in a patient with hpv-associated lsil of the cervice (clinical case)ФилоненкоЕ. В.FilonenkoE. V.derkul23@yandex.ruГригорьевыхН. И.GrigoryevykhN. I.КапринА. Д.KaprinA. D.«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian Federation2022151120221134044Copyright © Филоненко Е.В., Григорьевых Н.И., Каприн А.Д., 20222022Филоненко Е.В., Григорьевых Н.И., Каприн А.Д.Filonenko E.V., Grigoryevykh N.I., Kaprin A.D.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/553

В статье описывается клинический пример проведения своевременной, безопасной и эффективной фотодинамической терапии (ФДТ) у пациентки с диагнозом ассоциированной с вирусом папилломы человека (ВПЧ) СIN I шейки матки после неэффективной вакцинации 4-валентной вакциной гардасил. Клиническое наблюдение демонстрирует низкую эффективность вакцинации против ВПЧ больных с установленной ВПЧ инфекцией. У данной пациентки отсутствие адекватного лечения на протяжении около 1,5 лет привело к развитию ВПЧ ассоциированной CIN I шейки матки. В Центре лазерной и фотодинамической диагностики и терапии опухолей и МР МНИОИ им. П.А. Герцена пациентке проведен курс противовирусной ФДТ с достижением полной регрессии дисплазии и полной эрадикации вирусов ВПЧ. Лечение пациентка перенесла хорошо, без осложнений. Срок безрецидивного наблюдения – 19 мес.

The article describes a clinical example of timely, safe and effective photodynamic therapy (PDT) in a patient diagnosed with human papillomavirus (HPV) CIN I-associated cervical cancer after ineffective vaccination with 4-valent Gardasil vaccine. Clinical case demonstrates the low effectiveness of HPV vaccination in patients with established HPV infection. In this patient, the lack of adequate treatment for about 1.5 years led to the development of HPV associated CIN I of the cervix. Center for Laser and Photodynamic Diagnostics and Therapy of Tumors and MRI P.A. Herzen, the patient underwent a course of antiviral PDT with the achievement of complete regression of dysplasia and complete eradication of HPV viruses. The patient tolerated the treatment well, without complications. The period of relapse-free follow-up is 19 months.

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The authors declare that there are no conflicts of interest present.