References

bioph

Biomedical Photonics

2413-9432

Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis

10.24931/2413-9432-2015-4-2-9-16

bioph-56

Research Article

ОРИГИНАЛЬНЫЕ СТАТЬИ

ORIGINAL ARTICLES

Механизмы фотодинамического воздействия при лечении онкологических больных

The mechanisms of photodynamic action for treating of cancer patients

Акопов

А. Л.

Akopov

A. L.

Казаков

Н. В.

Kazakov

N. V.

Русанов

А. А.

Rusanov

A. A.

Карлсон

А.

Karlson

Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-Петербург, РоссияРоссияPavlov First Saint-Petersburg State Medical University, Saint-PetersburgRussian Federation

Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаРоссияPavlov First Saint-Petersburg State Medical University, Saint-PetersburgRussian Federation

2015

20062015

42916

2015

Акопов А.Л., Казаков Н.В., Русанов А.А., Карлсон А.

Akopov A.L., Kazakov N.V., Rusanov A.A., Karlson A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pdt-journal.com/jour/article/view/56

Представлены современные взгляды на механизмы терапевтического эффекта фотодинамической терапии при лечении онкологических больных. Описана история возникновения и развития метода. Перечислены основные требования, предъявляемые к веществам, используемым в качестве фотосенсибилизаторов. Проведен детальный обзор основных, применяемых в клинической практике в России и за рубежом, фотосенсибилизаторов, их химическая структура, основные спектральные характеристики. Кратко описаны методики их применения, диапазоны терапевтических доз, показания к применению, фармакокинетические особенности и побочные эффекты. Рассмотрены преимущества и недостатки наиболее популярных современных фотосенсибилизаторов, основные механизмы проникновения фотосенсибилизаторов разной химической структуры в опухолевые клетки. Показаны и подробно обсуждены три основных возможных звена противоопухолевого эффекта: прямое повреждение опухолевых клеток, нарушение сосудистой стромы опухолей и элиминация опухоли под воздействием иммунных клеток. Уделено внимание некрозу и апоптозу неоваскулярной сети – основным путям развития противоопухолевого действия при проведении фотодинамической терапии.

Current views on mechanisms of therapeutic effect of photodynamic therapy for treating of cancer patients are represented. The history of formation and development of the method is described. The main requirements for agents used as photosensitizers are listed. Detailed review of main photosensitizers used in clinical practice in Russia and in foreign countries with their chemical structure, main spectral characteristics was performed. Methods of its application, therapeutic dose ranges, indications, specifi c pharmacokinetic properties and side-effects are briefl y outlined. Advantages and disadvantages of the most popular modern photosensitizers, main mechanisms of entry of photosensitizers of different chemical structure into cancer cells are observed. Three main possible component of anti-tumor effect: direct damage of cancer cells, impairment of vascular stroma of tumor and elimination of tumor due to immune cells are shown and closely discussed. Necrosis and apotosis of neovascular net which are main development trends of anti-tumor action for photodynamic therapy are noticed.

фотодинамическая терапияфотосенсибилизаторсветовое воздействиефотодинамическая реакция

photodynamic therapyphotosensitizerlight exposurephotodynamic reaction

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The authors declare that there are no conflicts of interest present.