biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2022-11-4-32-40bioph-566Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSФлуоресцентная диагностика при немеланоцитарных опухолях кожиFluorescent diagnostics of non-melanoma skin cancerФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

derkul23@yandex.ruИванова-РадкевичВ. И.Ivanova-RadkevichV. I.

Москва

Moscow

«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationРоссийский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation2022310120231143240Copyright © Филоненко Е.В., Иванова-Радкевич В.И., 20232023Филоненко Е.В., Иванова-Радкевич В.И.Filonenko E.V., Ivanova-Radkevich V.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/566

Флуоресцентная диагностика – перспективный метод диагностики немеланоцитарных опухолей кожи, который позволяет выявить клинически не определяемые очаги рака кожи и уточнить границы распространения опухолевого процесса. Основными лекарственным препаратами для проведения флуоресцентной диагностики являются лекарства на основе 5-аминолевулиновой кислоты и ее метилового эфира. Показатели чувствительности флуоресцентной диагностики при базальноклеточном, плоскоклеточном раке кожи и экстрамаммарном раке Педжета достигают 79,0-100,0%, специфичности – 55,6-100%. Эффективность этого метода может снижаться за счет гиперкератинизации, ороговения и присутствия некротической ткани на поверхности опухолевых очагов. Сравнительные исследования результатов флуоресцентной диагностики и гистологического картирования при удалении опухоли методом микрографической хирургии Мооса показали высокую корреляцию результатов определения краев опухоли этими методами, что свидетельствует о том, что безопасная и технически легко выполнимая флуоресцентная диагностика может служить хорошей альтернативой микрографической хирургии Мооса – одному из наиболее точных, но достаточно трудозатратному и технически сложному методу определения границ очагов рака кожи.

Fluorescent diagnostics is a promising method for diagnosing non-melanocytic skin tumors, which makes it possible to identify clinically undetectable skin cancer foci and clarify the margin of the tumor lesion. The main drugs for ‹fluorescent diagnostics are drugs based on 5-aminolevulinic acid and its methyl ester. Sensitivity indicators of ‹fluorescent diagnostics in basal cell, squamous cell carcinoma and extramammary Paget’s disease reach 79.0-100.0%, speci city – 55.6-100%. But the effectiveness of this method may be reduced due to hyperkeratinization, keratinization, and the presence of necrotic tissue on the surface of tumor foci. Comparative studies of the results of ‹fluorescent diagnostics and histological mapping during tumor removal using Mohs micrographic surgery showed approximately equal results in the determining of the tumor edges by these methods, which indicates that safe and technically easily performed ‹fluorescent diagnostics can serve as a good alternative to Mohs micrographic surgery, one of the most accurate, but rather labor-intensive and technically complex method for determining the margin of skin cancer foci.

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The authors declare that there are no conflicts of interest present.