biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2023-12-1-28-36.bioph-582Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSФотодинамическая терапия больных псориазомPhotodynamic therapy of psoriasisФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

derkul23@yandex.ruИванова-РадкевичВ. И.Ivanova-RadkevichV.

Москва

Moscow

«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationРоссийский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation2023090520231212836Copyright © Филоненко Е.В., Иванова-Радкевич В.И., 20232023Филоненко Е.В., Иванова-Радкевич В.И.Filonenko E.V., Ivanova-Radkevich V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/582

Использование фотодинамической терапии (ФДТ) в лечении псориаза остается предметом многочисленных дискуссий. В научном сообществе нет единого мнения об эффективных и безопасных режимах ФДТ при псориазе. Описанные в литературе применяемые для лечения псориаза дозы и концентрации фотосенсибилизаторов, а также световые дозы различаются в десятки раз. Целью настоящего обзора является анализ эффективности и профиля безопасности различных схем применения ФДТ при псориазе. Ряд исследований демонстрирует 100%-ную эффективность метода в определенных режимах (полное или частичное очищение очагов псориаза после проведения ФДТ). В частности, такая эффективность была получена при применении аппликации 20%-ой 5-АЛК (световая доза 15 Дж/см2) и 0,1%-го метиленового синего (световая доза 15 Дж/см2). Основным фактором, ограничивающим применение ФДТ при псориазе и в отдельных случаях даже являющимся причиной прерывания лечения, является сильная болезненность во время процедуры облучения. Это требует тщательной отработки режимов ФДТ у пациентов с псориазом.

Photodynamic therapy (PDT) in the treatment of psoriasis remains the subject of much debate. There is no consensus in the scientific community about effective and safe PDT regimens for psoriasis. Described in the published materials doses and concentrations of photosensitizers for psoriasis, as well as light doses, differ by dozens of times. The purpose of this review is to analyze the efficacy and safety profile of various PDT regimens for psoriasis. Some studies demonstrate 100% effectiveness of the method in certain modes (complete or partial clearance of psoriasis foci after PDT). In particular, such efficiency was obtained with the application of 20% 5-ALA (light dose 15 J/cm2) and 0.1% methylene blue (light dose 15 J/ cm2). The main factor limiting the use of PDT in psoriasis, and in some cases even being the reason for treatment interruption, is severe pain during the irradiation procedure. This requires careful development of PDT regimens in patients with psoriasis.

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The authors declare that there are no conflicts of interest present.