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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bioph</journal-id><journal-title-group><journal-title xml:lang="ru">Biomedical Photonics</journal-title><trans-title-group xml:lang="en"><trans-title>Biomedical Photonics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2413-9432</issn><publisher><publisher-name>Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24931/2413-9432-2023-12-2-11-15</article-id><article-id custom-type="elpub" pub-id-type="custom">bioph-590</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Импульсный режим воздействия полупроводникового лазера с длиной волны 445 нм в фонохирургии: экспериментальное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Pulsed exposure mode of the 445 nm semiconductor laser in phonosurgery: an experimental study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p><p> </p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митрофанов</surname><given-names>Л. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitrofanova</surname><given-names>L. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Улупов</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ulupov</surname><given-names>M. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>В. А</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">valeriia.stepanova15@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стерхова</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sterkhova</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Pavlov First Saint Petersburg State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Almazov National Medical Research Centre<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>08</month><year>2023</year></pub-date><volume>12</volume><issue>2</issue><fpage>11</fpage><lpage>15</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рябова М.А., Митрофанов Л.Б., Улупов М.Ю., Степанова В.А., Стерхова К.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Рябова М.А., Митрофанов Л.Б., Улупов М.Ю., Степанова В.А., Стерхова К.А.</copyright-holder><copyright-holder xml:lang="en">Ryabova M.A., Mitrofanova L.B., Ulupov M.Y., Stepanova V.A., Sterkhova K.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pdt-journal.com/jour/article/view/590">https://www.pdt-journal.com/jour/article/view/590</self-uri><abstract><p>В работе представлены результаты экспериментального исследования, посвященного выбору наиболее оптимального режима импульсного контактного лазерного воздействия полупроводникового лазера с длиной волны 445 нм в хирургии голосовых складок (фонохирургии). Эндоларингеальная фонохирургия подразумевает собой максимальную сохранность анатомически и функционально значимых структур гортани в сочетании с радикальностью в отношении патологического процесса. С позиции мукоундулярной теории голосообразования волнообразные колебания голосовых складок возможны за счет подвижности покровного слоя голосовой складки (эпителий, поверхностный слой собственной пластинки) относительно ее тела (глубокий слой собственной пластинки, голосовая мышца). Таким образом, любая травматизация на уровне покровного слоя сопряжена с риском его избыточного рубцевания и потерей способности к волнообразному скольжению. Голосовые складки свиньи, по данным ряда авторов, имеют схожее строение с человеческими как по гистологическому строению (толщина слоев, соотношение коллагеновых и эластических волокон), так и по акустическим параметрам, что обосновывает рациональность их использования в качестве экспериментальной модели. В серии экспериментов с использованием лазера 445 нм проведены контактные импульсные воздействия на биологическую модель с длительностью импульсов 10, 20, 50 и 100 мс с последующей оценкой по данным гистологических срезов следующих параметров: глубина и ширина кратера абляции, ширина зоны бокового термического повреждения. Таким образом, описаны наиболее оптимальные для фонохирургических вмешательств режимы импульсных воздействий лазера с длиной волны 445 нм.</p></abstract><trans-abstract xml:lang="en"><p>The study presents the results of an experimental study devoted to the choice of the most optimal mode of pulsed contact laser exposure of semiconductor laser with a wavelength of 445 nm in phonosurgery, which implies maximum preservation of anatomically and functionally significant structures of the larynx combined with a radical approach to the pathological process. From the standpoint of the mucoundular theory of voice formation, wave-like oscillations of the vocal folds are possible due to the mobility of the cover layer of the vocal fold (epithelium, superficial layer of the lamina propria) relative to its body (deep layer of the lamina propria, vocal muscle). Thus, any injury at the level of the integumentary layer is associated with the risk of excessive scarring and loss of the ability to wave-like sliding. Pig vocal folds, according to a number of authors, have a structure similar to human ones in terms of both histological structure and acoustic parameters, which justifies the rationality of their use as an experimental model. In a series of experiments using a 445 nm laser, contact pulsed impacts on a biological model were carried out with pulse durations of 10, 20, 50, and 100 ms, followed by evaluation of the following parameters based on the data of histological sections: the depth and width of the ablation crater, the width of the zone of lateral thermal damage. Thus, the most optimal for phonosurgical interventions modes of pulsed laser exposures with a wavelength of 445 nm are described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фонохирургия</kwd><kwd>лазер 445 нм</kwd><kwd>дисфония</kwd><kwd>лазерная хирургия</kwd><kwd>ларингология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>phonosurgery</kwd><kwd>laser 445 nm</kwd><kwd>dysphonia</kwd><kwd>laser surgery</kwd><kwd>laryngology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hirano M. 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