biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2023-12-2-48-56bioph-594Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSФотодинамическая терапия при акнеPhotodynamic therapy of acneФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

elena.filonenko@list.ruИванова-РадкевичВ. И.Ivanova-RadkevichV. I.

Москва

Moscow

«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationРоссийский Университет дружбы народовРоссияRUDN UniversityRussian Federation2023210820231224853Copyright © Филоненко Е.В., Иванова-Радкевич В.И., 20232023Филоненко Е.В., Иванова-Радкевич В.И.Filonenko E.V., Ivanova-Radkevich V.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/594

Акне – одна из самых распространенных в мире кожных патологий. Ряд исследований показал, что фотодинамическая терапия (ФДТ) безопасна и эффективна при воспалительной и невоспалительной форме акне и может значительно улучшить состояние кожи при этом заболевании. Эффективность ФДТ против акне в основном обусловлена уменьшением количества кожного сала, вырабатываемого сальными железам, за счет снижения их активности в результате прямого фотодинамического повреждения сальных желез, эрадикацией Cutibacterium acnes и снижением уровня гиперкератоза. По сравнению с системной медикаментозной терапией лечение тяжелой формы акне методом ФДТ имеет следующие преимущества: быстрый результат, высокая эффективность, высокая селективность, отсутствие системных побочных реакций и лекарственной устойчивости, низкая частота рецидивов. Наиболее часто для ФДТ у больных акне применяют препараты на основе 5-аминолевулиновой кислоты (5-АЛК) и ее метилового эфира (МЭ-АЛК). На данный момент не существует единых рекомендаций по режимам ФДТ для лечения данной кожной патологии. Различные исследования демонстрируют высокую эффективность ФДТ с широким диапазоном доз 5-АЛК (3-20%) и МЭ-АЛК (4-16%), световых доз (15-120 Дж/ см2 ) и времени облучения (30-90 мин). Общая тенденция в исследованиях разных авторов сводится к тому, что щадящие низкоинтенсивные режимы ФДТ при акне демонстрируют такую же высокую эффективность при значительном снижении болевых ощущений в процессе облучения и местных кожных реакций (эритрема, отек, гиперпигментация).

Acne is one of the most common skin conditions in the world. A number of studies have shown that photodynamic therapy (PDT) is safe and effective for both inflammatory and non-inflammatory acne and can significantly improve skin conditions in this disease. The effectiveness of PDT against acne is mainly due to a decrease in the amount of sebum produced by the sebaceous glands due to a decrease in their activity as a result of direct photodynamic damage to the sebaceous glands, eradication of Cutibacterium acnes, and a decrease in the level of hyperkeratosis. Compared with systemic drug therapy, PDT treatment of severe acne has the following advantages: fast results, high efficiency, high selectivity, no systemic adverse reactions and drug resistance, and low recurrence rate. Most often for PDT in patients with acne, drugs based on 5-aminolevulinic acid (5-ALA) and its methyl ester (ME-ALA) are used. At the moment, there are no unified recommendations on PDT regimens for the treatment of this skin pathology. Various studies demonstrate the high efficiency of PDT with a wide range of doses of 5-ALA (3-20%) and ME-ALA (4-16%), light doses (15-120 J/cm2 ), and exposure time (30-90 min). The general trend in studies by different authors is that gentle low-intensity PDT regimens for acne demonstrate the same high efficiency with a significant reduction in pain during irradiation and local skin reactions (erythrema, edema, and hyperpigmentation).

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The authors declare that there are no conflicts of interest present.