biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2023-12-3-11-14bioph-603Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВозможности флюоресцентной диагностики в выявлении мультцентричных очагов дисплазии шейки маткиPossibilities of fluorescence diagnostics in detecting multicentric focies of cervical dysplasiaСмаиловаС. Б.SmailovaS. B.

Астана

Sandugash B. Smailova.

Astana

Sandugash.smailova@bk.ruШаназаровН. А.ShanazarovN. A.

Астана

Astana

ГришачеваТ. Г.GrishachevaT. G.

Санкт-Петербург

St. Petersburg

СальмагамбетоваС. Ж.SalmagambetovaS. Zh.

Астана

Astana

АлдабергенГ. С.AldabergenG. S.

Астана

Astana

РГП Больница Медицинского Центра Управления Делами президента на ПХВКазахстанMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanKazakhstanПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаРоссияFirst St. Petersburg State Medical University named after Academician I.P. PavlovRussian Federation2023231020231231114Copyright © Смаилова С.Б., Шаназаров Н.А., Гришачева Т.Г., Сальмагамбетова С.Ж., Алдаберген Г.С., 20232023Смаилова С.Б., Шаназаров Н.А., Гришачева Т.Г., Сальмагамбетова С.Ж., Алдаберген Г.С.Smailova S.B., Shanazarov N.A., Grishacheva T.G., Salmagambetova S.Z., Aldabergen G.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/603

Кольпоскопия позволяет исследователю локализовать потенциальные поражения, оценить тяжесть поражения и получить кольпоскопически  направленную  биопсию. Данный метод имеет ограниченную  чувствительность и специфичность,  вызывая серьезные опасения по поводу вероятности  пропуска  дисплазии шейки матки. Флуоресцентные  методы диагностики предраковых заболеваний шейки матки и ранних форм рака обладают крайне высокой чувствительностью, достигающей 90%. Представленные результаты исследования позволяют в полной мере заявить о высокой информативности флуоресцентной  кольпоскопии в выявлении диспластических очагов на шейке матки.

Colposcopy allows the examiner to localize potential lesions, assess the severity of the lesion, and obtain a colposcopic guided biopsy. This method has limited sensitivity and specificity, raising serious concerns about the possibility of missing cervical dysplasia. Fluorescent methods for diagnosing precancerous diseases of the cervix and early forms of cancer have an extremely high sensitivity, reaching 90%. The presented results of the study allow us to fully declare the high information content of fluorescent colposcopy in identifying dysplastic lesions on the cervix.

дисплазия шейки маткифлуоресцентная диагностикабиопсия шейки маткифотодинамическая терапияcervical dysplasiafluorescent diagnosticscervical biopsyphotodynamic therapyReferencesBray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin, 2018, vol. 68(6), рр. 394-424.Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin, 2018, vol. 68(6), рр. 394-424.Small W., Bacon M.A., Bajaj A., Chuang L.T., Fisher B.J., Harkenrider M.M., et al. Cervical cancer: A global health crisis: Cervical Cancer: A Global Health Crisis, Cancer, 2017, vol. 123(13), рр. 2404-2412.Small W., Bacon M.A., Bajaj A., Chuang L.T., Fisher B.J., Harkenrider M.M., et al. Cervical cancer: A global health crisis: Cervical Cancer: A Global Health Crisis, Cancer, 2017, vol. 123(13), рр. 2404-2412.The Institute of Leadership and Health Care Management of the Federal State Autonomous Educational Institution of Higher Education “The I. M. Sechenov First Moscow State Medical University” (Sechenov University). The condition and tendencies of cervical carcinoma diagnostic in the Russian Federation, Probl Soc Hyg Public Health Hist Med, 2021, vol. 29(6).The Institute of Leadership and Health Care Management of the Federal State Autonomous Educational Institution of Higher Education “The I. M. Sechenov First Moscow State Medical University” (Sechenov University). The condition and tendencies of cervical carcinoma diagnostic in the Russian Federation, Probl Soc Hyg Public Health Hist Med, 2021, vol. 29(6).Kaidarova D., Shatkovskaya O., Ongarbayev B., Seisenbayeva G., Azhmagambetova A., Zhylkaidarova A., et al. Indicators of the oncology service of the Republic of Kazakhstan, 2021 (statistical and analytical materials). JSC «Kazakh institute of oncology and radiology» at the ministry of the healthcare of the Republic of Kazakhstan, 2022.Kaidarova D., Shatkovskaya O., Ongarbayev B., Seisenbayeva G., Azhmagambetova A., Zhylkaidarova A., et al. Indicators of the oncology service of the Republic of Kazakhstan, 2021 (statistical and analytical materials). JSC «Kazakh institute of oncology and radiology» at the ministry of the healthcare of the Republic of Kazakhstan, 2022.Holcakova J., Bartosik M., Anton M., Minar L., Hausnerova J., Bednarikova M., et al. New Trends in the Detection of Gynecological Precancerous Lesions and EarlyStage Cancers, Cancers, 2021, vol. 13(24), р. 6339.Holcakova J., Bartosik M., Anton M., Minar L., Hausnerova J., Bednarikova M., et al. New Trends in the Detection of Gynecological Precancerous Lesions and EarlyStage Cancers, Cancers, 2021, vol. 13(24), р. 6339.World Health Organization. WHO technical guidance and specifications of medical devices for screening and treatment of precancerous lesions in the prevention of cervical cancer, Geneva: World Health Organization, 2020.World Health Organization. WHO technical guidance and specifications of medical devices for screening and treatment of precancerous lesions in the prevention of cervical cancer, Geneva: World Health Organization, 2020.Graham S.V. The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review, Clin Sci, 2017, vol. 131(17), рр. 2201-2221.Graham S.V. The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review, Clin Sci, 2017, vol. 131(17), рр. 2201-2221.Valls J., Baena A., Venegas G., Celis M., González M., Sosa C., et al. Performance of standardised colposcopy to detect cervical precancer and cancer for triage of women testing positive for human papillomavirus: results from the ESTAMPA multicentric screening study, Lancet Glob Health, 2023, vol. 11(3), рр. e350-360.Valls J., Baena A., Venegas G., Celis M., González M., Sosa C., et al. Performance of standardised colposcopy to detect cervical precancer and cancer for triage of women testing positive for human papillomavirus: results from the ESTAMPA multicentric screening study, Lancet Glob Health, 2023, vol. 11(3), рр. e350-360.Sabban F., Collinet P., Cosson M., Mordon S. Technique d’imagerie par fluorescence: intérêt diagnostique et thérapeutique en gynécologie, J Gynécologie Obstétrique Biol Reprod, 2004, vol. 33(8), рр. 734-38.Sabban F., Collinet P., Cosson M., Mordon S. Technique d’imagerie par fluorescence: intérêt diagnostique et thérapeutique en gynécologie, J Gynécologie Obstétrique Biol Reprod, 2004, vol. 33(8), рр. 734-38.He Z., Wang P., Liang Y., Fu Z., Ye X. Clinically Available Optical Imaging Technologies in Endoscopic Lesion Detection: Current Status and Future Perspective, J Healthc Eng, 2021, vol. 2021, рр. 1-27.He Z., Wang P., Liang Y., Fu Z., Ye X. Clinically Available Optical Imaging Technologies in Endoscopic Lesion Detection: Current Status and Future Perspective, J Healthc Eng, 2021, vol. 2021, рр. 1-27.Collinet P., Delemer M., Jouve E., Regis C., Farine M.O., Vinatier D., et al. Fluorescence diagnosis of cervical squamous intraepithelial lesions: A clinical feasability study, Photodiagnosis Photodyn Ther, 2007, vol. 4(2), рр. 112-116.Collinet P., Delemer M., Jouve E., Regis C., Farine M.O., Vinatier D., et al. Fluorescence diagnosis of cervical squamous intraepithelial lesions: A clinical feasability study, Photodiagnosis Photodyn Ther, 2007, vol. 4(2), рр. 112-116.Löning M., Diddens H., Friedrich M., Altgassen C., Diedrich K., Hüttmann G. Fluoreszenzdiagnostik und photodynamische Therapie mit 5-Aminolävulinsäure induziertem Protoporphyrin IX in der Gynäkologie: eine Übersicht, Zentralblatt Für Gynäkol, 2006, vol. 128(6), рр. 311-317.Löning M., Diddens H., Friedrich M., Altgassen C., Diedrich K., Hüttmann G. Fluoreszenzdiagnostik und photodynamische Therapie mit 5-Aminolävulinsäure induziertem Protoporphyrin IX in der Gynäkologie: eine Übersicht, Zentralblatt Für Gynäkol, 2006, vol. 128(6), рр. 311-317.Vansevičiūtė R., Venius J., Letautienė S. 5-Aminolevulinic acid-based fluorescence diagnostics of cervical preinvasive changes, Medicina (Mex), 2014, vol. 50(3), рр. 137-143.Vansevičiūtė R., Venius J., Letautienė S. 5-Aminolevulinic acid-based fluorescence diagnostics of cervical preinvasive changes, Medicina (Mex), 2014, vol. 50(3), рр. 137-143.Hillemanns P., Weingandt H., Baumgartner R., Diebold J., Xiang W., Stepp H. Photodetection of cervical intraepithelial neoplasia using 5-aminolevulinic acidinduced porphyrin fluorescence, Cancer, 2000, vol. 88(10), рр. 2275-2282.Hillemanns P., Weingandt H., Baumgartner R., Diebold J., Xiang W., Stepp H. Photodetection of cervical intraepithelial neoplasia using 5-aminolevulinic acidinduced porphyrin fluorescence, Cancer, 2000, vol. 88(10), рр. 2275-2282.

The authors declare that there are no conflicts of interest present.