biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2023-12-4-22-29bioph-622Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSФотодинамическая терапия пациентов с болезнью БоуэнаPhotodynamic therapy of Bowen’s diseaseФилоненкоЕ. В.FilonenkoE. V.

 Москва

elena.filonenko@list.ruИванова-РадкевичВ. И.Ivanova-RadkevichV. I.

 Москва

«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationРоссийский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation2023070320241242229Copyright © Филоненко Е.В., Иванова-Радкевич В.И., 20242024Филоненко Е.В., Иванова-Радкевич В.И.Filonenko E.V., Ivanova-Radkevich V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/622

Болезнь Боуэна – форма неинвазивного (in situ) плоскоклеточного рака кожи, локализованная в негенитальной области. Российские и европейские клинические рекомендации включают фотодинамическую терапию (ФДТ) в стандарты лечения пациентов с болезнью Боуэна. В настоящем обзоре по имеющимся литературным данным проанализированы эффективность и профиль безопасности различных схем применения ФДТ при болезни Боуэна. ФДТ может быть применена для воздействия на очаги болезни Боуэна большого размера, локализованные на участках тела, характеризующихся тяжелым заживлением, а также в случаях, когда хирургическое вмешательство представляется нецелесообразным. Анализ результатов исследований показывает, что ФДТ превосходит по эффективности и косметическим результатам традиционные местные методы лечение, такие как применение 5-фторурацила или криотерапию. Во всех проанализированных исследованиях у пациентов с болезнью Боуэна, ФДТ позволила достичь значимого клинического эффекта. Полная регрессия патологических очагов была достигнута у 67-100% пациентов. В исследованиях, оценивавших частоту рецидивов болезни Боуэна после ФДТ, значение этого показателя составляло 2-28%, в большинстве исследований 6-18%. Чаще всего для ФДТ при болезни Боуэна применяют 5-аминолевулиновую кислоту и ее метиловый эфир. По данным некоторых исследователей аминолевулиновая кислота позволяет достичь более долгосрочного положительного клинического эффекта с меньшей частотой развития болевых реакций в процессе лечения

Bowen’s disease is a form of non-invasive (in situ) squamous cell skin cancer localized in the non-genital area. Russian and European clinical guidelines include photodynamic therapy (PDT) in the standard of care for patients with Bowen’s disease. In the present review, the efficacy and safety profile of different PDT regimens for Bowen’s disease are analyzed according to the available literature data. PDT can be used to treat large Bowen’s disease lesions localized in areas of the body characterized by severe healing and in cases where surgery is not feasible. Analysis of the results of studies shows that PDT is superior in efficacy and cosmetic results to traditional local treatments such as 5-fluorouracil or cryotherapy. In all analyzed studies in patients with Bowen’s disease, PDT achieved a significant clinical effect. Complete regression of pathologic foci was achieved in 67-100% of patients. In studies evaluating the recurrence rate of Bowen’s disease after PDT, this value ranged from 2-28% with the range of 6-18% in most of the studies. Most often, 5-aminolevulinic acid and its methyl ester are used for PDT in Bowen’s disease. According to some researchers, aminolevulinic acid allows to achieve a more long-term positive clinical effect with a lower incidence of painful reactions during treatment

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The authors declare that there are no conflicts of interest present.