biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2024-13-2-43-48bioph-652Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSРоль трансмембранных переносчиков в накоплении 5-АЛК-индуцированного протопорфирина IX в опухолевых клеткахThe role of membrane transport proteins in 5-ALA-induced accumulation of protoporphyrin iX in tumor cellsИванова-РадкевичВ. И.Ivanova-RadkevichV. I.

Москва

Moscow

ivanova-radkevich-vi@rudn.ruКузнецоваО. М.KuznetsovaO. M.

Москва

Moscow

ФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

Российский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian Federation2024310720241324348Copyright © Иванова-Радкевич В.И., Кузнецова О.М., Филоненко Е.В., 20242024Иванова-Радкевич В.И., Кузнецова О.М., Филоненко Е.В.Ivanova-Radkevich V.I., Kuznetsova O.M., Filonenko E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/652

Одной из причин различий в эффективности фотодинамической терапии с применением 5-аминолевулиновой кислоты (5-АЛК) при различных типах злокачественных новообразований могут быть особенности экспрессии в этих тканях мембранных транспортеров, участвующих в переносе самой 5-АЛК в опухолевые и нормальные клетки, а также в выведении из клеток предшественников фотоактивного протопорфирина IX (ППIX) – уро-, копро- и протопорфириногенов. Повышенная экспрессия первых связана с увеличением интенсивности синтеза ППIX. При повышении экспрессии вторых наблюдается снижение скорости синтеза ППIX. В настоящем обзоре описаны основные транспортеры 5-АЛК, уро-, копро- и протопорфириногенов, приведены данные об их экспрессии в различных тканях, обсуждены возможности прогнозирования эффективности фотодинамической терапии с учетом экспрессии указанных транспортеров в злокачественных тканях.

Features of the expression of membrane importers of 5-ALA, as well as transporters involved in the removal of photoactive precursors of protoporphyrin IX (PPIX) (uro-, copro- and protoporphyrinogens), may cause differences in the effectiveness of photodynamic therapy of malignant neoplasms using 5-aminolevulinic acid (5-ALA). Increased expression of ALA transporters is associated with an increase in the intensity of PPIX synthesis. When the expression of PPIX exporters increases, there is a decrease in PPIX concentration. The review describes the main transporters of 5-ALA, uro-, copro- and protoporphyrinogens, provides data on their expression in various tissues, and discusses the possibility of predicting the effectiveness of photodynamic therapy considering the expression of the corresponding transport proteins in malignant tissues.

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The authors declare that there are no conflicts of interest present.