biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2024-13-4-33-39bioph-679Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSФотодинамическая терапия больных плоскоклеточным раком кожиPhotodynamic therapy of cutaneous squamous cell carcinomaФилоненкоЕ. В.FilonenkoE. V.

Москва

Moscow

elena.flonenko@list.ruИванова-РадкевичВ. И.Ivanova-RadkevichV. I.

Москва

Moscow

«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationРоссийский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation2024261220241343339Copyright © Филоненко Е.В., Иванова-Радкевич В.И., 20242024Филоненко Е.В., Иванова-Радкевич В.И.Filonenko E.V., Ivanova-Radkevich V.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/679

Фотодинамическая терапия традиционно применяется и одобрена во многих странах для лечения внутриэпителиальных форм плоскоклеточного рака и предрака – актинического кератоза и болезни Боуэна. Однако в последнее время был проведен ряд исследований, позволяющих сделать предположение о возможном расширении границ применения фотодинамической терапии при плоскоклеточном раке кожи. Несколькими авторами было высказано предположение о терапевтическом эффекте фотодинамической терапии при поверхностном, микроинвазивном и хорошо дифференцированном плоскоклеточном раке кожи. Мы провели обзор публикаций на сайте https://pubmed.ncbi.nlm.nih.gov, посвященных этой проблеме. Анализ результатов исследований показывает, что фотодинамическая терапия может позволить достичь высокой эффективности и хороших косметических результатов у пациентов с микроинвазивным плоскоклеточным раком кожи, а в ряде случаев – даже с инвазивной формой, и может быть рассмотрена, как альтернатива хирургическому лечению у пациентов с противопоказаниями к оперативному вмешательству.

Photodynamic therapy has traditionally been used and approved in many countries for the treatment of intraepithelial forms of cutaneous squamous cell carcinoma and precancer – actinic keratosis and Bowen’s disease. However, recently a number of studies have been conducted that suggest a possible expansion of the boundaries of photodynamic therapy for cutaneous squamous cell carcinoma. Several authors have suggested a therapeutic effect of photodynamic therapy for superficial, microinvasive and well-differentiated cutaneous squamous cell carcinoma. We reviewed publications on the website https://pubmed.ncbi.nlm.nih.gov devoted to this problem. Analysis of the research results shows that photodynamic therapy can achieve high efficiency and good cosmetic results in patients with microinvasive cutaneous squamous cell carcinoma, and in some cases even with an invasive form, and can be considered as an alternative to surgical treatment in patients with contraindications to surgery.

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The authors declare that there are no conflicts of interest present.