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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bioph</journal-id><journal-title-group><journal-title xml:lang="ru">Biomedical Photonics</journal-title><trans-title-group xml:lang="en"><trans-title>Biomedical Photonics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2413-9432</issn><publisher><publisher-name>Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">bioph-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE-REPORTS</subject></subj-group></article-categories><title-group><article-title>Уникальное клиническое наблюдение метахронного опухолевого поражения головного мозга различной гистологической структуры</article-title><trans-title-group xml:lang="en"><trans-title>The unique case-report of metachronous brain tumors of different histology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцев</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaitsev</surname><given-names>А. М.</given-names></name></name-alternatives><bio xml:lang="ru"><p> </p><p> </p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куржупов</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurgupov</surname><given-names>М. I.</given-names></name></name-alternatives><email xlink:type="simple">mkurzhupov@nsi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пучков</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Puchkov</surname><given-names>V. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра нейрохирургии</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Национальный медицинский исследовательский радиологический центр Минздрава России, Москва, Россия<country>Россия</country></aff><aff xml:lang="en">P.A.Herzen Moscow Cancer Research Institute<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Российская медицинская академия непрерывного профессионального образования, Москва, Россия<country>Россия</country></aff><aff xml:lang="en">The department of neurosurgery of Russian Medical Academy of Post-Graduate Education<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>20</day><month>03</month><year>2013</year></pub-date><volume>2</volume><issue>1</issue><fpage>42</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зайцев А.М., Куржупов М.И., Пучков В.Л., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Зайцев А.М., Куржупов М.И., Пучков В.Л.</copyright-holder><copyright-holder xml:lang="en">Zaitsev А.М., Kurgupov М.I., Puchkov V.L.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pdt-journal.com/jour/article/view/7">https://www.pdt-journal.com/jour/article/view/7</self-uri><abstract><p>Описан случай нестандартного с точки зрения нейроонкологии течения опухолевого поражения головного мозга – метахронного развития в головном мозге сначала метастатического поражения рака молочной железы, затем злокачественной глиомы. Хирургическое лечение обеих опухолей выполнено с применением интраоперационной флюоресцентной диагностики и фотодинамической терапии. Благодаря комплексному лечению больная прожила 15 месяцев с момента постановки диагноза рака молочной железы IV стадии (с метастатическим поражением головного мозга.</p><p> </p></abstract><trans-abstract xml:lang="en"><p> The case of unusual course of brain tumor process – metachronous development of breast cancer brain metastasis and then development of malignant glioma is reported. The surgical treatment for both tumors were performed with intraoperative fluorescence diagnosis and photodynamic therapy. Due to multimodality treatment the patient was alive for 15 months from diagnosis of IV stage breast cancer (brain metastasis).</p><p> </p></trans-abstract><kwd-group xml:lang="ru"><kwd>метахронное опухолевое поражение головного мозга</kwd><kwd>интраоперационная флюоресцентная диагностика</kwd><kwd>интраоперационная фотодинамическая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metachronous brain tumor</kwd><kwd>intraoperative fluorescence diagnosis</kwd><kwd>intraoperative photodynamic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Коршунов А.Г. Классификация опухолей нервной системы. Клиническая неврология / Под ред. А.Н. Коновалова. Т. III. Ч. 1. Гл. 6. М., 2004. – С. 171.</mixed-citation><mixed-citation xml:lang="en">Коршунов А.Г. Классификация опухолей нервной системы. Клиническая неврология / Под ред. А.Н. Коновалова. Т. III. Ч. 1. Гл. 6. 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