biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2025-14-2-31-39bioph-720Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSКлинические исследования фотодинамической терапии с 5-AЛК при дисплазии шейки матки: от пилотных исследований до современных разра6отокClinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developmentsШаназаровН. А.ShanazarovN. A.

Астана

Astana

АйткалиевА. Д.AitkaliyevA. D.

Астана

Astana

aitkaliyev1998@gmail.comГришачеваТ. Г.GrishachevaT. G.

Санкт-Петербург

Saint-Petersburg

КисиковаС. Д.KissikovaS. D.

Астана

Astana

ЗинченкоС. В.ZinchenkoS. V.

Казань

Kazan

КасиеваБ. С.KassiyevaB. S.

Астана

Astana

СмаиловаС. Б.SmailovaS. B.

Астана

Astana

СальмагамбетоваЖ. Ж.SalmagambetovaZh. Zh.

Астана

Astana

СейтбековаК.SeitbekovaK.

Астана

Astana

Больница Медицинского центра Управления делами Президента Республики КазахстанКазахстанMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanKazakhstanПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. ПавловаРоссияPavlov First Saint-Petersburg State Medical UniversityRussian FederationКазанский (Приволжский) федеральный университетРоссияKazan (Volga Region) Federal UniversityRussian Federation2025010720251423139Copyright © Шаназаров Н.А., Айткалиев А.Д., Гришачева Т.Г., Кисикова С.Д., Зинченко С.В., Касиева Б.С., Смаилова С.Б., Сальмагамбетова Ж.Ж., Сейтбекова К., 20252025Шаназаров Н.А., Айткалиев А.Д., Гришачева Т.Г., Кисикова С.Д., Зинченко С.В., Касиева Б.С., Смаилова С.Б., Сальмагамбетова Ж.Ж., Сейтбекова К.Shanazarov N.A., Aitkaliyev A.D., Grishacheva T.G., Kissikova S.D., Zinchenko S.V., Kassiyeva B.S., Smailova S.B., Salmagambetova Z.Z., Seitbekova K.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/720

Неоперативные методы терапии имеют важное значение для снижения скорости прогрессирования дисплазий шейки матки, ассоциированных с вирусом папилломы человека (BПЧ), от CIN 1 до CIN 2/3, а затем до рака шейки матки, при минимальных по6очных эффектах и осложнениях у женщин, таких как кровотечения, сужение шейки матки, спонтанные а6орты и преждевременные роды. Фотодинамическая терапия (ФДТ) привлекла значительное внимание как неинвазивный метод лечения CIN в последние годы. ФДТ основана на применении фотоактивных соединений, известных как фотосенси6илизаторы, которые накапливаются в целевых клетках. Затем эти клетки подвергаются воздействию света с определенной длиной волны. Цель данной ра6оты — о6зор клинического развития и исследования эффективности ФДТ с фотосенси6илизатором 5-аминолевулиновой кислоты (5-AЛК) для лечения CIN 1–3, начиная с ранних пилотных исследований и заканчивая последними отчетами.Ранние исследования ФДТ с использованием низких концентраций 5-AЛК показали низкую эффективность, но недавние исследования с концентрацией 20% 5-AЛК продемонстрировали лучшие результаты. Для установления оптимального количества сеансов ФДТ, нео6ходимых для устранения BПЧ, тре6уются 6олее крупные исследования, желательно проводимые в нескольких центрах.

Non-surgical therapies are essential for reducing the progression rate of human papillomavirus-associated cervical intraepithelial neoplasia (CIN) from low-grade (CIN 1) to high-grade CIN (CIN 2/3) and subsequently to cervical cancer with minimal adverse reactions and complications in women, such as haemorrhaging, cervical stenosis, spontaneous abortion, and preterm birth.Photodynamic therapy (PDT) has garnered considerable attention as a non-invasive approach to CIN treatment in recent years. PDT works by applying photoactive compounds, known as photosensitizers, that accumulate in target cells. Subsequent exposure of these cells to light of a specific wavelength (photoactivation) occurs. This paper aims to review the clinical development of clinical research on the effectiveness of PDT with a 5-Aminolevulinic acid (5-ALA) photosensitiser for treating CIN 1-3 from the early preliminary studies to recent reports.Early PDT studies using lower concentrations of 5-ALA showed poor effectiveness, but recent research with a 20% concentration of 5-ALA demonstrated better outcomes. Larger studies, preferably conducted across multiple centres, are needed to establish the optimal number of PDT sessions required to eliminate HPV.

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The authors declare that there are no conflicts of interest present.