biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2025-14-3-43-51bioph-731Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSФотодинамическая терапия с 5-АЛК больных базальноклеточным раком кожиPhotodynamic therapy with 5-aminolevulinic acid for basal squamous cell carcinomaФилоненкоЕ. В.FilonenkoE. V.

Москва

 Moscow

elena.filonenko@list.ruИванова-РадкевичВ. И.Ivanova-RadkevichV. I.

Москва

Moscow

Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationRussian FederationРоссийский Университет дружбы народовРоссияPeoples’ Friendship University of Russia (RUDN University)Russian Federation2025171020251434351Copyright © Филоненко Е.В., Иванова-Радкевич В.И., 20252025Филоненко Е.В., Иванова-Радкевич В.И.Filonenko E.V., Ivanova-Radkevich V.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/731

Целью нашей работы были сбор и анализ опубликованных данных клинических исследований эффективности фотодинамической терапии (ФДТ) с препаратами на основе 5-АЛК и ее эфиров у пациентов с базальноклеточным раком кожи (БКРК). Анализ литературы проводился на основе базы данных PubMed и ClinicalTrials.gov за период с 1995 по 2025 гг. В анализ были включены крупные проспективные и ретроспективные исследования с количеством пациентов свыше 20 человек. Рассматривалась эффективность ФДТ, было выполнено сравнение с традиционными методами лечения. Проведенный анализ показал значительную эффективность ФДТ при лечении БКРК. Частота полных регрессий достигала от 84% до 99% через 3 мес после начала терапии, от 62% до 96% через 12 мес и от 70% до 91% через 5 лет. Зарегистрирован значительно лучший косметический результат по сравнению с хирургическими методами. Исследования подтвердили, что ФДТ обладает высоким профилем безопасности с редким развитием тяжелых побочных эффектов. Наиболее частые негативные последствия включают легкое раздражение кожи, покраснения и небольшой дискомфорт, проходящие самостоятельно.

The aim of the study was to collect and analyze published data from clinical trials on the efficacy of photodynamic therapy (PDT) using 5-ALA-based drugs and its esters in patients with basal cell carcinoma (BCC). The review was conducted using the PubMed and ClinicalTrials.gov databases for the period from 1995 to 2025. Large prospective and retrospective studies with more than 20 patients were included in the analysis. The efficacy of PDT was examined and compared with traditional treatment methods. The analysis demonstrated significant efficacy of PDT in the treatment of BCC. The complete regression rate ranged from 84% to 99% after 3 months of therapy, from 62% to 96% after 12 months, and from 70% to 91% after 5 years. A significantly better cosmetic outcome was recorded compared with surgical methods. Studies have confirmed that PDT has a high safety profile, with severe side effects rare. The most common adverse effects include mild skin irritation, redness, and mild discomfort, which resolve on their own.

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The authors declare that there are no conflicts of interest present.