<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bioph</journal-id><journal-title-group><journal-title xml:lang="ru">Biomedical Photonics</journal-title><trans-title-group xml:lang="en"><trans-title>Biomedical Photonics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2413-9432</issn><publisher><publisher-name>Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24931/2413-9432-2025-14-4-49-55</article-id><article-id custom-type="elpub" pub-id-type="custom">bioph-761</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE-REPORTS</subject></subj-group></article-categories><title-group><article-title>Комбинированная фотодинамическая терапия при метастатическом раке молочной железы: возможности и результаты (клиническое наблюдение)</article-title><trans-title-group xml:lang="en"><trans-title>Combined photodynamic therapy for metastatic breast cancer: possibilities and results (clinical case)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаназаров</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shanazarov</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кумисбекова</surname><given-names>Р. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kumisbekova</surname><given-names>R. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana </p></bio><email xlink:type="simple">raushankumisbekova@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Албаев</surname><given-names>Р. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Albaev</surname><given-names>R. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усенбай</surname><given-names>М.</given-names></name><name name-style="western" xml:lang="en"><surname>Usenbay</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ташпулатов</surname><given-names>Т. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Tashpulatov</surname><given-names>T. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Магзамова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Magzamova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana </p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дисаенко</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Disaenko</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костанай</p></bio><bio xml:lang="en"><p>Kostanay</p></bio><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Больница Медицинского центра Управления делами Президента Республики Казахстан</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>Hospital of the President’s Affairs Administration</institution><country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Многопрофильный медицинский центр акимата г. Астаны</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>Multidisciplinary Medical Center, Akimat of Astana</institution><country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Городская поликлиника № 4 акимата г. Астана</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>City Polyclinic No. 4, Akimat of Astana</institution><country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Многопрофильная областная больница при Управлении Здравоохранения Акмолинской области</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>Multidisciplinary Regional Hospital, Health Department of Akmola Region</institution><country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Костанайская Городская Онкологическая Многопрофильная больница</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>Kostanay City Multidisciplinary Oncology Hospital</institution><country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>12</day><month>02</month><year>2026</year></pub-date><volume>14</volume><issue>4</issue><fpage>49</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шаназаров Н.А., Кумисбекова Р.К., Албаев Р.К., Усенбай М., Ташпулатов Т.Б., Магзамова А.С., Дисаенко К.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Шаназаров Н.А., Кумисбекова Р.К., Албаев Р.К., Усенбай М., Ташпулатов Т.Б., Магзамова А.С., Дисаенко К.С.</copyright-holder><copyright-holder xml:lang="en">Shanazarov N.A., Kumisbekova R.K., Albaev R.K., Usenbay M., Tashpulatov T.B., Magzamova A.S., Disaenko K.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pdt-journal.com/jour/article/view/761">https://www.pdt-journal.com/jour/article/view/761</self-uri><abstract><p>Центр фотодинамической терапии Больницы Медицинского центра Управления делами Президента Республики Казахстан имеет клинический опыт лечения кожных метастазов рака молочной железы. В настоящей работе представлены результаты наблюдения за пациенткой с метастатическим раком молочной железы, которой была проведена комбинированная фотодинамическая терапия, включающая системную фотомодификацию крови и локальное воздействие на очаги поражения. Клинический случай представляет особый интерес, поскольку пациентка не получала стандартных методов противоопухолевого лечения, таких как химио- и гормонотерапия. Это обусловлено пожилым возрастом и сниженной переносимостью агрессивных лечебных схем на фоне сопутствующих заболеваний, что ограничивает возможности проведения традиционной терапии. Несмотря на отсутствие системного лечения, применение комбинированной фотодинамической терапии позволило достичь выраженного положительного клинического эффекта. Отмечено уменьшение размеров и инфильтрации кожных метастатических очагов, улучшение общего состояния и качества жизни пациентки. Полученные результаты демонстрируют потенциал фотодинамической терапии как эффективного и безопасного альтернативного метода воздействия при метастатическом раке молочной железы, особенно в клинических ситуациях, когда проведение стандартных схем лечения невозможно или противопоказано.</p></abstract><trans-abstract xml:lang="en"><p>The Center for Photodynamic Therapy of the Hospital of the Medical Center of the Administrative Department of the President of the Republic of Kazakhstan has clinical experience in treating cutaneous metastases of breast cancer. This paper presents the results of clinical observation of a patient with metastatic breast cancer who underwent combined photodynamic therapy, including systemic photomodification of blood and local irradiation of metastatic lesions. This clinical case is of particular interest since the patient did not receive standard antitumor treatments such as chemotherapy or hormone therapy. This was due to advanced age and decreased tolerance to aggressive treatment regimens associated with comorbidities, which limited the feasibility of conventional therapy. Despite the absence of systemic treatment, the use of combined photodynamic therapy resulted in a pronounced positive clinical response. A reduction in the size and infiltration of cutaneous metastatic lesions, as well as an improvement in the patient’s general condition and quality of life, were observed. These findings demonstrate the potential of photodynamic therapy as an effective and safe alternative therapeutic approach for metastatic breast cancer, particularly in clinical situations where the use of standard treatment protocols is impossible or contraindicated.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фотодинамическая терапия</kwd><kwd>рак молочной железы</kwd><kwd>паллиативное лечение</kwd><kwd>качество жизни</kwd></kwd-group><kwd-group xml:lang="en"><kwd>photodynamic therapy</kwd><kwd>breast cancer</kwd><kwd>palliative care</kwd><kwd>quality of life</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Absolute numbers, Incidence, Females, in 2022 [Электронный ресурс] // International Agency for Research on Cancer – URL: https://gco.iarc.who.int/today/en/dataviz/pie?mode=cancer&amp;group_populations=1&amp;sexes=2</mixed-citation><mixed-citation xml:lang="en">International Agency for Research on Cancer. Absolute numbers, incidence, females, in 2022 [Electronic resource]. Available from: https://gco.iarc.who.int/today/en/dataviz/pie?mode=cancer&amp;group_populations=1&amp;sexes=2.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Shanazarov N., Zhapparov Y., Kumisbekova R., Turzhanova D., Zulkhash N. Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population // Asian Pac. J. Cancer Prev. – 2023. – Vol. 24. – P. 4195-4207. doi: 10.31557/APJCP.2023.24.12.4195.</mixed-citation><mixed-citation xml:lang="en">Shanazarov N., Zhapparov Y., Kumisbekova R., Turzhanova D., Zulkhash N. Association of gene polymorphisms with breast cancer risk in the Kazakh population. Asian Pac. J. Cancer Prev, 2023, vol. 24, pp. 4195-4207. doi: 10.31557/APJCP.2023.24.12.4195.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Тюляндин С.А., Артамонова Е.В., Жигулев А.Н. и соавт. Рак молочной железы. Практические рекомендации RUSSCO, часть 1.2 // Злокачественные опухоли. – 2024. – Т. 14, № 3s2. – С. 32-81. doi: 10.18027/2224–5057-2024-14-3s2-1.2–01.</mixed-citation><mixed-citation xml:lang="en">Tyulyandin S.A., Artamonova E.V., Zhigulev A.N., et al. Breast cancer. Practical recommendations of RUSSCO, part 1.2. Malig. Tumors, 2024, vol. 14 (3s2), pp. 32-81. doi: 10.18027/2224-5057-2024-14-3s2-1.2-01.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Жукова Л.Г., Андреева Ю.Ю., Завалишина Л.Э., и др. Рак молочной железы: клинические рекомендации // Современная онкология. – 2021. – Т. 23, № 1. – С. 5-40. doi: 10.26442/18151434.2021.1.200823.</mixed-citation><mixed-citation xml:lang="en">Zhukova L.G., Andreeva Y.Y., Zavalishina L.E., Zakiriyakhodjaev A.D., Koroleva I.A., Nazarenko A.V., et al. Breast cancer: Clinical guidelines. Mod. Oncol, 2021, vol. 23 (1), pp. 5-40. doi: 10.26442/18151434.2021.1.200823.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Гельфонд М.Л., Рогачёв М.В. Фотодинамическая терапия: фундаментальные и практические аспекты: учебное пособие для обучающихся в системе высшего и дополнительного проф. образования. – Санкт-Петербург: НМИЦ онкологии им. Н.Н. Петрова Минздрава РФ. – 2018. – С. 148.</mixed-citation><mixed-citation xml:lang="en">Gelfond M.L., Rogachev M.V. Photodynamic therapy: fundamental and practical aspects. A textbook for students of higher and additional professional education. St. Petersburg: N.N. Petrov National Medical Research Center of Oncology. Ministry of Health of the Russian Federation, 2018, рр. 148.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Correia J.H., Rodrigues J.A., Pimenta S., Dong T., Yang Z. Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions // Pharmaceutics. – 2021. – Vol. 13(9). – Article 1332. doi: 10.3390/pharmaceutics13091332.</mixed-citation><mixed-citation xml:lang="en">Correia J.H., Rodrigues J.A., Pimenta S., Dong T., Yang Z. Photodynamic therapy review: principles, photosensitizers, applications, and future directions. Pharmaceutics, 2021, vol. 13 (9), рр. article 1332. doi: 10.3390/pharmaceutics13091332.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Banerjee S.M., El-Sheikh S., Malhotra A., Mosse C.A., Parker S., Williams N.R., MacRobert A.J., Hamoudi R., Bown S.G., Keshtgar M.R. Photodynamic Therapy in Primary Breast Cancer // J. Clin. Med. – 2020. – Vol. 9(2). – P. 483. doi: 10.3390/jcm9020483.</mixed-citation><mixed-citation xml:lang="en">Banerjee S.M., El-Sheikh S., Malhotra A., Mosse C.A., Parker S., Williams N.R., et al. Photodynamic therapy in primary breast cancer. J. Clin. Med, 2020, vol. 9 (2), pр. 483. doi: 10.3390/jcm9020483.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Горанская Е.В., Рагулин Ю. А., Капинус В. Н. и др. Непосредственные результаты фотодинамической терапии внутрикожных метастазов рака молочной железы // Онкохирургия. – 2011. – Т. 3, № 2. – С. 21-22.</mixed-citation><mixed-citation xml:lang="en">Goranskaya E.V., Ragulin Yu.A., Kapinus V.N., et al. Immediate results of photodynamic therapy for intradermal metastases of breast cancer. Oncosurgery, 2011, vol. 3 (2), pp. 21-22.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Moret F., Reddi E. Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT) // J. Porphyr. Phthalocyanines. – 2017. – Vol. 21. – P. 239-256.</mixed-citation><mixed-citation xml:lang="en">Moret F., Reddi E. Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT). J. Porphyr. Phthalocyanines, 2017, vol. 21, pp. 239-256.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Анохин А.А. и др. Опухолеспецифический иммунный ответ после фотодинамической терапии // Медицинский журнал. – 2016. – Т. 18, № 5. – С. 405-416. doi: 10.15789/1563–0625-2016-5-405-416.</mixed-citation><mixed-citation xml:lang="en">Anokhin A.A., et al. Tumor-specific immune response after photodynamic therapy. Med. J, 2016, vol. 18 (5), pp. 405-416. doi: 10.15789/1563-0625-2016-5-405-416.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Филоненко Е. В., Серова Л. Г. Фотодинамическая терапия в клинической практике // Biomedical Photonics. – 2016. – Т. 5, № 2. – С. 26-37.</mixed-citation><mixed-citation xml:lang="en">Filonenko E.V., Serova L.G. Photodynamic therapy in clinical practice. Biomedical Photonics, 2016, vol. 5 (2), pp. 26-37.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Рахимжанова Р.И., Шаназаров Н.А., Туржанова ДЕ. Фотодинамическая терапия внутрикожных метастазов рака молочной железы (обзор литературы) // Biomedical Photonics. – 2019. – Т. 8, № 3. – С. 36-42. doi: 10.24931/2413–9432-2019-8-3-36–42.</mixed-citation><mixed-citation xml:lang="en">Rakhimzhanova R.I., Shanazarov N.A., Turzhanova D.E. Photodynamic therapy of intradermal metastases of breast cancer (literature review). Biomedical Photonics, 2019, vol. 8 (3), pp. 36-42. doi: 10.24931/2413-9432-2019-8-3-36-42.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shanazarov N., Zinchenko S., Zhapparov E., et al. The Clinical Case of Successful Application of Photodynamic Therapy in the Skin Metastases Treatment of Breast Cancer // BioNanoSci. – 2021. – Vol. 11. – P. 957-961. doi: 10.1007/s12668-021-00907-5.</mixed-citation><mixed-citation xml:lang="en">Shanazarov N., Zinchenko S., Zhapparov E., et al. The clinical case of successful application of photodynamic therapy in the treatment of skin metastases of breast cancer. BioNanoSci., 2021, vol. 11, pp. 957-961. doi: 10.1007/s12668-021-00907-5.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Li T., Yan L. Functional Polymer Nanocarriers for Photodynamic Therapy // Pharmaceuticals (Basel). – 2018. – Vol. 11(4). – P. 133.</mixed-citation><mixed-citation xml:lang="en">Li T., Yan L. Functional polymer nanocarriers for photodynamic therapy. Pharmaceutics (Basel), 2018, vol. 11 (4), pр. 133</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
