biophBiomedical PhotonicsBiomedical Photonics2413-9432Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis10.24931/2413-9432-2016-5-2-4-12bioph-87Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСпектрально-люминесцентные свойства наночастиц бактериохлорина и фталоцианина алюминия в качестве поверхностного покрытия имплантов на основе гидроксиапатитаSpectral luminescent properties of bacteriochlorin and aluminum phthalocyanine nanoparticles as hydroxyapatite implant surface coatingМаклыгинаЮ. С.MaklyginaYu. S.

Москва

Moscow

ШароваА. С.SharovaA. S.

Москва

Moscow

KunduB.KunduB.

Kolkata

Kolkata

BallaV. K.BallaV. K.

Kolkata

Kolkata

SteinerR.SteinerR.

Москва;

Ulm

Moscow;

Ulm

ЛощеновВ. Б.LoschenovV. B.

Москва

Moscow

loschenov@mail.ruИнститут общей физики им. А.М. Прохорова РАН, Москва, РоссияРоссияGeneral Physics Institute of the Russian Academy of SciencesRussian FederationНациональный исследовательский ядерный университет МИФИ, Москва, РоссияРоссияNational Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Russian FederationBioceramics and Coating Division, CSIR-Central Glass & Ceramic Research Institute, Kolkata, IndiaИндияBioceramics and Coating Division, CSIR-Central Glass and Ceramic Research InstituteIndiaНациональный исследовательский ядерный университет МИФИ; The Institute for Laser Technology in Medicine and Measurement TechniqueГерманияNational Research Nuclear University MEPhI (Moscow Engineering Physics Institute); The Institute for Laser Technology in Medicine and Measurement TechniqueGermanyИнститут общей физики им. А.М. Прохорова РАН; Национальный исследовательский ядерный университет МИФИРоссияGeneral Physics Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Russian Federation20160907201652412Copyright © Маклыгина Ю.С., Шарова А.С., Kundu B., Balla V.K., Steiner R., Лощенов В.Б., 20162016Маклыгина Ю.С., Шарова А.С., Kundu B., Balla V.K., Steiner R., Лощенов В.Б.Maklygina Y.S., Sharova A.S., Kundu B., Balla V.K., Steiner R., Loschenov V.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pdt-journal.com/jour/article/view/87

Разработана перспективная технология покрытия поверхности имплантов нанокристаллами фотосенсибилизаторов для придания им фотобактерицидных свойств. В ходе работы было проведено исследование спектрально-люминесцентных свойств покрытий на основе наночастиц фотосенсибилизаторов, поглощающих в ближнем инфракрасном диапазоне спектра: бактериохлорина и фталоцианина алюминия. Было показано, что при взаимодействии с полярным растворителем, что моделирует процесс взаимодействия импланта с биокомпонентами в условиях in vivo (быстро пролиферирующими и иммунокомпетентными клетками), кристаллические наночастицы фотосенсибилизаторов, покрывающие имплант, меняют свои спектроскопические свойства: приобретают способность к фотолюминесценции и становятся фототоксичными. Показана устойчивость разработанного покрытия к вымыванию нанокристаллов во времени. Сделан вывод, что разработанное покрытие на основе кристаллических наночастиц фотосенсибилизаторов будет оказывать антибактериальное и противовоспалительное действие в условиях фотодинамического воздействия в околоимплантационной зоне. Результаты проведенных исследований позволяют считать данную технологию перспективной для создания имплантов с фотобактерицидными свойствами, что открывает перспективу локальной профилактики воспалительных и аутоиммунных реакций в области имплантации.

The development and the spectral research of unique coating as crystalline nanoparticles of IR photosensitizers were performed for the creation of hydroxyapatite implants with photobactericidal properties. It has been proved that by the interaction of nanoparticles covering implant with the polar solvent, which simulates the interaction of the implant with the biocomponents in vivo (fast proliferating and with immunocompetent cells), photosensitizers nanoparticles change the spectroscopic properties, becoming fluorescent and phototoxic. Thus, the developed coating based on crystalline photosensitizer nanoparticles with studied specific properties should have antibacterial, anti-inflammatory effect by the photodynamic treatment in the near implant area. This research opens the prospect of the local prevention of inflammatory and autoimmune reactions in the area of implantation. The results of the study suggest a promising this technology in order to create implants with photobactericidal properties.

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The authors declare that there are no conflicts of interest present.