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MULTIPLE-COURSE PHOTODYNAMIC THERAPY FOR VERRUCOUS LEUKOPLAKIA OF MUCOUS MEMBRANE OF BODY OF THE TONGUE (CASE REPORT)

https://doi.org/10.24931/2413-9432-2016-5-3-41-42

Abstract

The results of treatment of the patient with verrucous luekoplakia of mucous membrane of body of the tongue with photodynamic therapy are represented. In 2015 the patient underwent 4 courses of photodynamic therapy with photosensitizer photolon. Photolon was injected at dose of 2 mg/kg 3 h before irradiation (laser output power was 0.262 W, light dose – 50 and 100 J/cm2). The result of treatment was assessed as complete regression: 4 months after multiple-course photodynamic therapy there were no clinical and histological signs of luekoplakia.

About the Authors

Yu. P. Istomin
N.N. Alexandrov National Cancer Centre of Belarus, Lesnoy, Republic of Belarus
Russian Federation


T. P. Artemyeva
N.N. Alexandrov National Cancer Centre of Belarus, Lesnoy, Republic of Belarus
Russian Federation


D. A. Tzerkovsky
N.N. Alexandrov National Cancer Centre of Belarus, Lesnoy, Republic of Belarus
Russian Federation


References

1. Istomin Yu.P., Artemyeva T.P., Tzerkovsky D.A. Photodynamic therapy with photosensitizer photolon for oral leukoplakia, Biomedical Pho-tonics, 2016, Vol. 5, No. 2, pp. 13–20. (in Russian).

2. Skorodumova L.O., Muraev A.A., Volodina E.V., Ivanov S.Yu., Gnuchev N.V., Georgiev G.P., Larin S.S. Leukoplakia of oral mucosa: classification, histopathology, methods of diagnosis and treatment, Voprosy onkologii, 2013, Vol. 59, No. 5, pp. 548-554. (in Russian).

3. Chen H.M., Yu C.H., Tu P.C., Yeh C.Y., Tsai T., Chiang C.P. Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy, Lasers Surg. Med., 2005, Vol. 37, pp. 114-122.

4. Aghahosseini F., Arbabi-Kalati F., Fashtami L.A., Djavid G.E., Fateh M., Beitollahi J.M. Methylene blue-mediated photodynamic therapy: a possible alternative treatment for oral lichen planus, Lasers Surg. Med., 2006, Vol. 38, pp. 33-38.

5. Jerjes W., Upile T., Hamdoon Z., Mosse C.A., Akram S., Hopper C. Photodynamic therapy outcome for oral dysplasia, Lasers Surg. Med., 2011, Vol. 43, pp. 192-199.


Review

For citations:


Istomin Yu.P., Artemyeva T.P., Tzerkovsky D.A. MULTIPLE-COURSE PHOTODYNAMIC THERAPY FOR VERRUCOUS LEUKOPLAKIA OF MUCOUS MEMBRANE OF BODY OF THE TONGUE (CASE REPORT). Biomedical Photonics. 2016;5(3):41-42. (In Russ.) https://doi.org/10.24931/2413-9432-2016-5-3-41-42

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ISSN 2413-9432 (Print)