USE OF AUTOFLUORESCENCE DERMATOSCOPY IN PATIENTS WITH PSORIASIS
https://doi.org/10.24931/2413-9432-2017-6-2-21-26
Abstract
Results of autofluorescence dermatoscopy using videodermatoscope «EcoSkin» in patients with different dermatologic diseases are represented. The study included 64 patients, 27 of them had different types of psoriasis, 11 – acne, 3 – rosacea, 5 – eczema, 3 – mite-induced dermatitis, 4 – superficial mycosis of the glabrous skin, 7 – atopic dermatitis, 4 – seborrheic dermatitis. The major changes of autofluorescence were detected in pathological foci in patients with psoriasis. Authors suppose that increased autofluorescence of porphyrins in psoriatic plaques in the study is associated with enhanced prolyferation in pathological tissues and with liver dysfunction. The analysis of autofluorescence images in patients with rosacea, eczema, atopic and mite-induced dermatitis did not show significant difference in autofluorescence images of affected skin comparing with intact skin in same patients. In patients with acne a pattern of spot red-orange autofluorescence of skin in seborrheic areas corresponding with location of openings of pilosebaceous apparatus was detected that was associated by authors with Propionibacterium acnes infection.
About the Authors
N. N. Petrishchev
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
G. V. Papayan
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
A. V. Krylov
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
E. V. Krylova
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
S. Kim
SOI-Korea Center
Korea, Republic of
Korea, Republic of
References
1. Sokolovskii E.V., Petukhova A.V., Smirnova T.S., Slobodzyan G.V., Kudryashov Yu.M., Lungu S.M., Bychkova A.A. Analysis of psoriasis incidence in Saint-Petersburg, Zhurnal dermatovenerologii i kosmetologii, 2002, No. 2, pp. 6-9. (in Russian).
2. Kucherenko V.Z., Stukalova N.Ya. Sudy of life quality characteristics in patients with psoriasis as important step of treatment and diagnosis process, Zdorov'e i obrazovanie v XXI veke, 2006, Vol. 8, No. 9, pp. 433. (in Russian).
3. Parrish J.A., Jaenicke K.F., Anderson R.R. Erythema and melanogenesis action spectra of normal human skin, Photochem Photobiol., 1982, Vol. 36 (2), pp. 187-191.
4. Zeng H., MacAulay C., Palcic B., McLean D. A computerized autofluorescence and diffuse reflectance spectroanalyser system for in vivo skin studies, Phys Med Biol, 1993, Vol. 38, pp. 231-240.
5. Fritch C., Ruzichka T. Fluorescence Diagnosis and Photodynamic Therapy of Skin Diseases. Atlas and Handbook. Wien-New-York, Springer-Verlag Publ., 2003. 124 p.
6. Stringer M.R., Collins P., Robinson D.J., Stables G.I., SheehanDare R.A. The accumulation of protoporphyrin IX in plaque psoriasis after topical application of 5-aminolevulinic acid indicates a potential for superficial photodynamic therapy, J Invest Dermatol, 1996, Vol. 107, No 1, pp. 176-181.
7. Smits T., Kleinpenning M.M., van Erp P.E.J., van de Kerkhof P.C.M., Gerritsen M-J.P. A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acidphotodynamic therapy in patients with psoriasis, British Journal of Dermatology, 2006, Vol. 155, No. 2, pp. 429-436.
8. Kleinpenning M.M., Smits T., Ewalds E., van Erp P.E.J., van de Kerkhof P.C.M., Gerritsen M.J.P. Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study, British Journal of Dermatology, 2006, Vol. 155, No. 3, pp. 539-545.
9. Bissonnette R., Zeng H., McLean D.I., Korbelik M., Lui H. Oral aminolevulinic acid induces protoporphyrin IX fluorescence in psoriatic plaques and peripheral blood cells, Photochemistry and Photobiology, 2001, Vol. 74, No. 2, pp. 339-345.
10. Smits T., Robles C.A., van Erp P.E.J., van de Kerkhof P.C.M., Gerritsen M.-J.P. Correlation Between Macroscopic Fluorescence and Protoporphyrin IX Content in Psoriasis and Actinic Keratosis Following Application of Aminolevulinic Acid, Journal of Investigative Dermatology, 2005, Vol. 125, pp. 833-839.
11. Stringer M.R., Robinson D.J., Collins P. Establishment of treatment parameters for ALA-PDT of plaque psoriasis, Proceedings of SPIE, 1996, Vol. 2924, pp. 314-318.
12. Filonenko E.V., Grishaeva A.B. Methodological aspects of the fluorescence diagnosis of malignancies by using alasens, Rossiiskii onkologicheskii zhurnal, 2011, No. 5, pp. 30-33. (in Russian).
13. Filonenko E.V., Khanmurzaeva A.G. Fluorescent diagnostics with alasense in patients with skin cancer, Lazernaya meditsina, 2012, Vol. 16, No. 3, pp. 32-34. (in Russian).
14. Bissonnette R., Zeng H., McLean D., Schreiber W., Roscoe D., Lui H. Psoriatic Plaques Exhibit Red Autofluorescence that is Due to Protoporphyrin IX, Journal of Investigative Dermatology, 1998, Vol. 111, pp. 586-591.
15. Zeng H., Lui H., MacAulay C., Palcic, B., McLean D. Spectrometer system for diagnosis of skin disease. US6008889, 1999.
16. Lui H., MacAulay C., Zeng H., McLean D., Bissonnette R. Photoactivation of endogenous porphyrins for treatment of psoriasis. US6269818, 2001.
17. Kang U., Papayan G.V., Bae S.-J., Berezin B.B., Kim S. Fluorescence dermatoscope, Opticheskii zhurnal, 2008, Vol. 75, No. 1, pp. 32-38. (in Russian).
18. Papayan G.V., Petrishchev N.N., Araviiskaya E.R., Sokolovskii E.V., Romanova O.L., Dmitrieva N.Yu., Kang U. Evaluation of efficacy of external therapy for acne by analysis of color fluorescence images of skin, in Aktual’nye problemy lazernoi meditsiny [Current issues of laser medicine], by eds Petrishchev N.N. Saint Petersburg, Mezhdunarodnyi obshchestvennyi Fond kul'tury i obrazovaniya Publ., 2016, pp. 201-210.
19. Vel'sher Z.V., Stakhanov L.M., Kotova O.E. Use of autofluorescence study in diagnosis of recurrent basal cell skin cancer and estimation of sufficiency of laser removal of tumor, Khirurg, 2008, No. 1, pp. 51-57. (in Russian).
Review
For citations:
Petrishchev N.N., Papayan G.V., Krylov A.V., Krylova E.V., Kim S. USE OF AUTOFLUORESCENCE DERMATOSCOPY IN PATIENTS WITH PSORIASIS. Biomedical Photonics. 2017;6(2):21-26. (In Russ.) https://doi.org/10.24931/2413-9432-2017-6-2-21-26
Views:
1195
Email this article 