400-470 NM RADIATION INACTIVATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
Abstract
Staphylococcus aureus is one of the major reasons for nosocomial infections that often cause post-surgery wound infectious complications. Prevalence in hospitals as well as occurrence in the community of the clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) leave health professionals without effective means of control over the infection. Complications caused by MRSA lead to longer hospital stay and higher lethality rates. Due to the infected wounds treatment issues and high mortality rate it is important to introduce efficient alternatives to traditional means of treating and preventing wound infections into the clinical practice of inpatient surgical units and burn care facilities. It should be hard for bacteria to develop resistance to these treatment methods and measures of preventive care. Antimicrobial action of the 400-470 nm radiation attracts a lot of attention lately. Shortwave visible radiation has distinct advantages over UVC and UVB given the generally acknowledged skin injury risks and risks of development of cancer resulting from the ultraviolet exposure. In comparison with the photodynamic therapy the 400-470 nm radiation does not require exogenous photosensitizers with their challenging delivery to a biofilm lying deep within a tissue. Despite research being in its infancy, in vitro and in vivo studies performed to inactivate clinically signifi cant isolates of bacteria characterized by antibiotic resistance suggest that the phototherapy technology using the 400-470 nm radiation has the potential to treat and prevent surgical and burn wound infections. In this paper effectiveness of 400-470 nm radiation for the inactivation of strains of MRSA is analyzed.
About the Authors
O. V. Kuzmin
Kuban State University
Laser BioMed LLC
Russian Federation
Russian Federation
N. I. Faskhutdinova
Kuban State University
Laser BioMed LLC
Russian Federation
Russian Federation
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Review
For citations:
Kuzmin O.V., Faskhutdinova N.I. 400-470 NM RADIATION INACTIVATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS. Biomedical Photonics. 2017;6(4):37-43. (In Russ.)
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