Comparative experimental study of 5-ALA and 5-ALA hexyl ester specific activity
https://doi.org/10.24931/2413-9432-2018-7-3-43-46
Abstract
A comparative experimental study of the specific activity of drugs based on 5-aminolevulinic acid (5-ALA) and its hexyl ester (5-ALA HE) was carried out. Their ability to induce the synthesis of photoactive protoporphyrin IX in the healthy tissues of the rabbit bladder when instilling the drug solutions at various concentrations has been estimated. It was shown that 5-ALA HE results in the induction and accumulation of PPIX in the rabbit bladder epithelium at much lower concentrations than 5-ALA. Thus, a significant increase in the fluorescence intensity in comparison with the control was achieved by instillation of 5-ALA HE solution in the rabbit’ bladder at a concentration of only 0.0001% (fluorescence intensity 2.20±0.60 a.u.), and for 5-ALA – only when using a solution at a concentration of 0.3% (fluorescence intensity 2.60±1.02 a.u.).
About the Authors
R. I. Yakubovskaya
P.Herzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
A. A. Pankratov
P.Herzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
E. V. Filonenko
.Herzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation;
I.M. Sechenov First Moscow State Medical University
Russian Federation
Moscow
Russian Federation
Moscow
E. A. Lukyanets
State Scientific Center Scientific Research Institute Organic Intermediates and Dyes
Russian Federation
Moscow
Russian Federation
Moscow
V. I. Ivanova-Radkevich
State Scientific Center Scientific Research Institute Organic Intermediates and Dyes;
Peoples’ Friendship University of Russia (RUDN University)
Russian Federation
Moscow
Russian Federation
Moscow
A. A. Trushin
I.M. Sechenov First Moscow State Medical University
Russian Federation
Moscow
Russian Federation
Moscow
A. D. Kaprin
P.Herzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation;
Peoples’ Friendship University of Russia (RUDN University)
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Yakubovskaya R.I., Pankratov A.A., Filonenko E.V., Lukyanets E.A., Ivanova-Radkevich V.I., Trushin A.A., Kaprin A.D. Comparative experimental study of 5-ALA and 5-ALA hexyl ester specific activity. Biomedical Photonics. 2018;7(3):43-46. https://doi.org/10.24931/2413-9432-2018-7-3-43-46
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