Сонодинамическая и соно-фотодинамическая терапия в онкологии
Аннотация
В представляемой публикации авторами произведен анализ результатов применения сонодинамической и соно-фотодинамической терапии с фотосенсибилизирующими агентами различных классов (гематопорфирин, 5-аминолевулиновая кислота, производные хлорина и др.) в экспериментальных исследованиях и клинической онкологии. В ряде in vitro и in vivo исследований доказана высокая противоопухолевая эффективность указанных выше методов лечения. Ультразвуковое воздействие с частотой импульсов 1–3 МГц и интенсивностью от 0,7 до 5 Вт/см2 в отдельности и в комбинации с фотооблучением экспериментальных опухолей, позволяет существенно повысить эффективность лечения. Это стало основой для апробации методов у пациентов со злокачественными новообразованиями различных локализаций. Учеными из стран Юго-Восточной Азии представлены предварительные результаты применения сонодинамической и соно-фотодинамической терапии с фотосенсибилизаторами в лечении злокачественной патологии молочной железы, желудка, пищевода, предстательной железы, легкого и головного мозга. Анализ полученных данных свидетельствует об отсутствии серьезных нежелательных явлений и повышении противоопухолевой эффективности лечения, в которое были включены данные методы лечения с фотосенсибилизаторами хлоринового ряда.
Об авторах
Д. А. Церковский
Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова
Беларусь
Лесной
Беларусь
Лесной
Е. Л. Протопович
Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова
Беларусь
Лесной
Беларусь
Лесной
Д. С. Ступак
Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова
Беларусь
Лесной
Беларусь
Лесной
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Рецензия
Для цитирования:
Церковский Д.А., Протопович Е.Л., Ступак Д.С. Сонодинамическая и соно-фотодинамическая терапия в онкологии. Biomedical Photonics. 2019;8(2):31-46. https://doi.org/10.24931/2413-9432-2019-8-2-31-46
For citation:
Tzerkovsky D.A., Protopovich E.L., Stupak D.S. Sonodynamic and sono-photodynamic therapy in oncology. Biomedical Photonics. 2019;8(2):31-46. https://doi.org/10.24931/2413-9432-2019-8-2-31-46
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