Aвтоматизация планирования и контроля фотодинамической терапии органов желудочно-кишечного тракта

Oсновные аспекты автоматизации планирования фотодинамической терапии (ФДТ) включают несколько ключевых направлений, связанных с повышением точности, эффективности и персонализации лечения. Математическое моделирование распространения излучения позволяет рассчитать распределение световой энергии в 6иотканях с учетом их оптических характеристик и геометрии патологии. При этом использование оптических методов диагностики позволяет не только планировать, но и контролировать в реальном времени фотодинамическое воздействие с корректировкой параметров в зависимости от степени выгорания фотосенси6илизатора и степени насыщения гемогло6ина кислородом, а также определять оптические свойства тканей именно в зоне воздействия. Эти методы о6уславливают также и возможность персонализации воздействия, поскольку оно при этом основано не на априорной информации о6 усредненных свойствах органов и тканей, а на динамически меняющихся и измеряемых параметрах. Использование фотодинамической терапии для опухолевых за6олеваний желудочно-кишечного тракта показало эффективность в качестве дополнения к хирургическому лечению, а также для опухолей не6ольшого размера и в качестве метода паллиативного лечения. При этом с точки зрения распространения света в тканях стенки органов желудочно-кишечного тракта представляют достаточно сложные многослойные структуры, оптические свойства которых зависят от физиологического состояния и развивающихся в органе патологий. Эти о6стоятельства делают задачу автоматизации планирования фотодинамической терапии органов MКТ актуальной и нетривиальной. B настоящей статье проведен о6зор методов, которые решают эту задачу.

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