Application of the Kubelka-Munk model for fast intraoperative analysis of intestinal optical properties using a fiber optic spectrometer
https://doi.org/10.24931/2413-9432-2025-14-3-30-38
Abstract
Intraoperative determination of optical properties of biological tissues is an important task of medical physics, in particular, for photodynamic therapy, because it allows personalizing photodynamic treatment by accurately calculating the required light dose. In this work, we propose a new approach to simultaneous measurement of diffuse reflectance and transmission spectra of the colon wall tissue during intestinal anastomosis, based on the use of two fiber-optic devices to deliver broadband radiation both from the side of the intestinal lumen and from the outer side of the intestinal wall, from which diffuse scattered light is also recorded. To restore the optical properties of these tissues it was proposed to use the Kubelka-Munk model with transformation of the optical parameters of the model into the optical parameters of the diffusion approximation theory with custom equations based on the results of numerical modeling. The proposed approach have been tested ex vivo on the biological samples of GIT tissues, allowing us to conclude on its applicability in clinical conditions.
Supporting agencies: The work was funded by the Russian Science Foundation, grant No. 25-25-00516.
About the Authors
T. A. Savelieva
Prokhorov General Physics Institute of the Russian Academy of Sciences; Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI
Russian Federation
Russian Federation
Moscow
A. A. Krivetskaya
Prokhorov General Physics Institute of the Russian Academy of Sciences; Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI
Russian Federation
Russian Federation
Moscow
D. M. Kustov
Prokhorov General Physics Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow
M. I. Klobukov
Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI
Russian Federation
Russian Federation
Moscow
I. D. Romanishkin
Prokhorov General Physics Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow
K. G. Linkov
Prokhorov General Physics Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow
V. V. Levkin
Department of Faculty Surgery No. 1, I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Moscow
S. S. Kharnas
Department of Faculty Surgery No. 1, I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Moscow
V. B. Loschenov
Prokhorov General Physics Institute of the Russian Academy of Sciences; Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Savelieva T.A., Krivetskaya A.A., Kustov D.M., Klobukov M.I., Romanishkin I.D., Linkov K.G., Levkin V.V., Kharnas S.S., Loschenov V.B. Application of the Kubelka-Munk model for fast intraoperative analysis of intestinal optical properties using a fiber optic spectrometer. Biomedical Photonics. 2025;14(3):30-38. https://doi.org/10.24931/2413-9432-2025-14-3-30-38
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