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Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer

https://doi.org/10.24931/2413-9432-2015-4-3-29-35

Abstract

The main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with 5-aminolevulinic acid (5-ALA) allows to improve the sensibility of routine cystoscopy, but low specificity decreases its diagnostic accuracy. The method of fluorescence imaging combined with local fluorescence spectroscopy developed in P.A. Herzen MCRI has been shown to increase the specificity from 71% to 84%. Thus, local fluorescence spectroscopy in visible fluorescence of 5-ALA-induced protoporphyrin allows to perform guided biopsy and decrease the rate of diagnostic mistakes.

 

About the Authors

I. G. Rusakov
SBEI of HPE « I.M. Sechenov First Moscow State Medical University», Moscow, Russia
Russian Federation


A. A. Teplov
FSBI «A.V. Vishnevsky Institute of Surgery», Moscow, Russia
Russian Federation


R. V. Ulianov
P.A. Herzen MCRI (branch of FSBI «NMRRC» of the Ministry of Health of the Russian Federation), Moscow, Russia
Russian Federation


E. V. Filonenko
P.A. Herzen MCRI (branch of FSBI «NMRRC» of the Ministry of Health of the Russian Federation), Moscow, Russia SBEI of HPE « I.M. Sechenov First Moscow State Medical University», Moscow, Russia
Russian Federation


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Review

For citations:


Rusakov I.G., Teplov A.A., Ulianov R.V., Filonenko E.V. Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer. Biomedical Photonics. 2015;4(3):29-35. (In Russ.) https://doi.org/10.24931/2413-9432-2015-4-3-29-35

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ISSN 2413-9432 (Print)