Investigation of methods for modeling light propagation in multilayer biological tissues for calculating the absorbed dose of laser radiation

A. A. Krivetskaya; T. A. Savelieva; D. M. Kustov; V. V. Levkin; S. S. Kharnas; V. B. Loschenov

doi:10.24931/2413-9432-2026-15-1-19-29

Investigation of methods for modeling light propagation in multilayer biological tissues for calculating the absorbed dose of laser radiation

A. A. Krivetskaya, T. A. Savelieva, D. M. Kustov, V. V. Levkin, S. S. Kharnas, V. B. Loschenov

https://doi.org/10.24931/2413-9432-2026-15-1-19-29

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Abstract

Studying the interaction of optical wavelength radiation with biological tissues can be used in various biomedical applications, including estimating the absorbed dose of laser radiation during laser-induced therapy. The fraction of absorbed radiation can be estimated using Monte Carlo and adding-doubling simulations. In this paper, we compare the simulation results obtained using the two methods for multilayered models of biological tissues of the trachea and colon. Both methods are used to calculate the absorbed dose based on the specified optical properties of tissues under several types of illumination. Similar incident beam geometries demonstrated repeatability of 94Ѓ}3% for a collimated beam and 95Ѓ}3% for an isotropic/diffuse source. The advantage of the adding-doubling method is its higher computational speed compared to the Monte Carlo method, while Monte Carlo simulation allows for varying a larger number of parameters when specifying the illumination conditions of the sample. The data obtained can be used to optimize dosimetry in photodynamic therapy.

Keywords

optical property, adding-doubling method, Monte Carlo method, multilayer biological tissue, absorbed dose, laser dosimetry

About the Authors

A. A. Krivetskaya

Prokhorov General Physics Institute of the Russian Academy of Sciences; Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI
Russian Federation

Moscow

T. A. Savelieva

Prokhorov General Physics Institute of the Russian Academy of Sciences; Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI
Russian Federation

Moscow

D. M. Kustov

Prokhorov General Physics Institute of the Russian Academy of Sciences
Russian Federation

Moscow

V. V. Levkin

Department of Faculty Surgery No. 1, I.M. Sechenov First Moscow State Medical University
Russian Federation

Moscow

S. S. Kharnas

Department of Faculty Surgery No. 1, I.M. Sechenov First Moscow State Medical University
Russian Federation

Moscow

V. B. Loschenov

Prokhorov General Physics Institute of the Russian Academy of Sciences; Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI
Russian Federation

Moscow

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Review

For citations:

Krivetskaya A.A., Savelieva T.A., Kustov D.M., Levkin V.V., Kharnas S.S., Loschenov V.B. Investigation of methods for modeling light propagation in multilayer biological tissues for calculating the absorbed dose of laser radiation. Biomedical Photonics. 2026;15(1):19-29. https://doi.org/10.24931/2413-9432-2026-15-1-19-29

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