Analysis of collagen presence in brain tumors using spontaneous Raman scattering spectroscopy

As brain tumors progress, excess collagen increases the rigidity of the extracellular matrix, which promotes metastasis, impedes drug penetration, and reduces the effectiveness of therapy. A detailed study of collagen as a promising biomarker of malignancy is highly relevant for complementing histopathology for accurate diagnosis and treatment planning. This study proposes an approach to detect collagen in intracranial tumor tissues using spontaneous Raman spectroscopy with excitation at a wavelength 785 nm.

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