PHOTODYNAMIC THERAPY FOR HEAD AND NECK BASAL CELL SKIN CANCER WITH ADDITIONAL INTERSTITIAL LASER IRRADIATION
https://doi.org/10.24931/2413-9432-2017-6-4-20-26
Abstract
The article is devoted to the development and evaluation of the effi ciency of photodynamic therapy (PDT) with photosensitizer photolon with additional interstitial laser irradiation in patients with head and neck basal cell skin cancer (BCSC). Treatment was performed in 55 patients. On the fi rst stage, all patients underwent photodynamic therapy with interstitial irradiation using fl exible optical fi bers with cylindrical diffuser, on the second stage PDT with distant delivery of laser at a dose of 50-300 J/cm2 was carried out. During the follow- up period of 6 months to 4 years in 13 (23.6%) of the 55 patients a recurrence of the disease was diagnosed. A higher rate of recurrence was in the group of patients who underwent PDT for recurrent neoplasms compared with patients with primary disease (37.5% and 4.3%, respectively), in patients with endophytic growth of the tumor compared to patients with exophytic component (30.0% and 16.0%,
respectively) and in patients with large tumors (up to 2.0 cm – 14.3%, from 2.0 to 5.0 cm – 16.7% and more than 5.0 cm – 54.4%).
About the Authors
V. N. Kapinus
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
M. A. Kaplan
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. V. Yaroslavtseva-Isayeva
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
I. S. Spichenkova
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
1. Tsyb A.F., Kaplan M.A., Romanko Yu.S., Popuchiev V.V. Fotodinamicheskaya terapiya [Photodynamic therapy]. Мoscow, МIA Publ., 2009. 195 p. (in Russian)
2. Stranadko E.F., Ryabov M.V. Twenty-year experience of photodynamic therapy in skin cancer, Lazernaya meditsina, 2012, Vol. 16, No. 2, pp. 19-25. (in Russian)
3. Kapinus V.N., Kaplan M.A., Spichenkova I.S., Shubina A.M., Yaroslavtseva-Isaeva E.V. Photodynamic therapy of cutaneous squamous cell carcinoma with photosensitizer photolon, Lazernaya meditsina, 2012, Vol. 16, No. 2, pp. 31-35. (in Russian)
4. Kapinus V.N., Kaplan M.A., Spichenkova I.S., Yaroslavtseva-Isaeva E.V., Shubina A.M., Goranskaya E.V. Possibilities of photodynamic therapy in the treatment of recurrent basal cell carcinoma, Onkologiya. Zhurnal im. P.A. Gertsena, 2013, No. 4, pp. 40-44. (in Russian)
5. Savoia P., Deboli T., Previgliano A., Broganelli P. Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma, Int. J. Mol. Sci., 2015, Vol. 16(10), pp. 23300-23317.
6. Volgin V.N. Fotodinamicheskaya terapiya bazal'no-kletochnogo raka kozhi pri interstitsial'nom vvedenii fotoditazina: metodicheskie rekomendatsii [Photodynamic therapy of basal cell skin cancer with interstitial introduction of photoditazine: guidelines]. Moscow, GVKG im. N. N. Burdenko Publ., 2008. 67 p. (in Russian)
7. Calzavara-Pinton P., Arisi M., Sereni E., Ortel B. A critical reappraisal of off- label indications for topical photodynamic therapy with aminolevulinic acid and methylaminolevulinate, Rev. Recent. Clin. Trials, 2010, Vol. 5, No. 2, pp. 112-116.
8. Sidoroff A., Thaler P. Taking treatment decisions in non-melanoma skin cancer - the place for topical photodynamic therapy (PDT), Photodiagnosis Photodyn. Ther., 2010, Vol. 7, No. 1, pp. 24-32.
9. Volgin V.N., Stranadko E.F., Lamotkin I.A., Ryabov M.V. Optimization of photodynamic therapy regimes applied for treating basal-cell skin cancer with Photosens, Lazernaya meditsina, 2007, Vol. 11, No. 1, pp. 50-54. (in Russian)
10. Stranadko E.F., Volgin V.N., Ryabov M.V. Photodynamic therapy for basal cell skin cancer with Photohem, Klinicheskaya dermatologiya i venerologiya, 2008, No. 6, pp. 28-33. (in Russian)
11. Stranadko E.F., Volgin V.N., Lamotkin I.A., Ryabov M.V., Sadovskaya M.V. Photodynamic therapy for basal cell skin cancer with photosensitizer Photoditazin, Rossiiskii bioterapevticheskii zhurnal, 2008, Vol. 7, No. 4, pp. 7-11. (in Russian)
12. Betz C.S., Rauschning W., Stranadko E.P., Riabov M.V., Volgin V.N., Albrecht V., Nifantiev N.E., Hopper C. Long-term outcomes following Foscan®-PDT of basal cell carcinomas, Lasers Surg Med, 2012, Vol. 44(7), pp. 533-540.
13. Filonenko E.V. Fluorescent diagnostics with alasense in patients with skin cancer, Lazernaya meditsina, 2016, Vol. 16, No. 3, pp. 32-34. (in Russian)
14. Lou P.J., Jager H.R., Jones L., Theodossy T., Bown S.G., Hopper C. Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer, Br. J. Cancer, 2004, Vol. 91, No. 3, pp. 441-446.
15. Jager H.R., Taylor M.N., Theodossy T., Hopper C. MR imaging-guided interstitial photodynamic laser therapy for advanced head and neck tumors, AJNR Am J Neuroradiol, 2005, Vol. 26, No. 5, pp. 1193-1200.
16. Biel M. Advances in photodynamic therapy for the treatment of head and neck cancers, Lasers Surg. Med., 2006, Vol. 38, No. 5, pp. 349-355.
17. Jerjes W., Upile T., Hamdoon Z., Nhembe F., Bhandari R., Mackay S., Shah P., Mosse C. A., Brookes J. A., Morley S., Hopper C. Ultrasoundguided photodynamic therapy for deep seated pathologies: prospective study, Lasers Surg. Med., 2009, Vol. 41, No. 9, pp. 612-621.
18. Huang Z., Xu H., Meyers A.D., Musani A.I., Wang L., Tagg R., Barqawi A.B., Chen Y.K. Photodynamic therapy for treatment of solid tumors - potential and technical challenges, Technol. Cancer Res. Treat., 2008, Vol. 7, No. 4, pp. 309-320.
19. Burch S., London C., Seguin B., Rodriguez C., Wilson B.C., Bisland S.K. Treatment of canine osseous tumors with photodynamic therapy: a pilot study, Clin Orthop Relat Res, 2009, Vol. 467, No. 4, pp. 1028-1034.
20. Rendon A., Beck J.C., Lilge L. Treatment planning using tailored and standard cylindrical light diffusers for photodynamic therapy of the prostate, Phys Med Biol, 2008, Vol. 53, No. 4, pp. 1131-1149.
21. Tanaka H., Hashimoto K., Yamada I., Masumoto K., Ohsawa T., Murai M., Hirano T. Interstitial photodynamic therapy with rotating and reciprocating optical fibers, Cancer, 2001, Vol. 91, No. 9, pp. 1791-1796.
22. Vogl T.J., Eichler K., Mack M.G., Zangos S., Herzog C., Thalhammer A., Engelmann K. Interstitial photodynamic laser therapy in interventional oncology, Eur Radiol, 2004, Vol. 14, No. 6, pp. 1063-1073.
23. Lou P.J., Jager H.R., Jones L., Theodossy T., Bown S.G., Hopper C. Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer, Br. J. Cancer, 2004, Vol. 91, No. 3, pp. 441-446.
Review
For citations:
Kapinus V.N., Kaplan M.A., Yaroslavtseva-Isayeva E.V., Spichenkova I.S. PHOTODYNAMIC THERAPY FOR HEAD AND NECK BASAL CELL SKIN CANCER WITH ADDITIONAL INTERSTITIAL LASER IRRADIATION. Biomedical Photonics. 2017;6(4):20-26. (In Russ.) https://doi.org/10.24931/2413-9432-2017-6-4-20-26
Views:
1259
Email this article 