Combined endoscopic treatment of a patient with cancer of the hypopharynx to the upper third of the esophagus with complete clinical and endoscopic effect
https://doi.org/10.24931/2413-9432-2018-7-4-35-40
Abstract
We present a clinical case with a complete endoscopic and clinical effect after endoscopic treatment of a patient with laryngeal cancer involving the upper third of the esophagus. The patient was treated as follows: conformal radiation therapy TFD = 40 gr, targeted chemotherapy using Cetuximab (total dose of 1800 mg). 1.5 months after the end of the treatment, a residual laryngopharyngeal tumor with a spread into the upper third of the esophagus was found during videolaryngoscopy examination. The result of the following histological examination was G2 squamous cell carcinoma. From August 2015 to February 2017, the patient underwent 8 photodynamic therapy sessions in combination with argon plasma coagulation. A control videolaryngoscopy, carried out 1 month after the fnal session, showed complete tumor regression without cicatricial deformity and narrowing of the esophageal lumen.
About the Authors
V. M. Legostaev
Rostov Research Institute of Oncology, Rostov-on-Don
Russian Federation
Russian Federation
O. Y. Babenkov
Rostov Research Institute of Oncology, Rostov-on-Don
Russian Federation
Russian Federation
G. V. Balitskiy
Rostov Research Institute of Oncology, Rostov-on-Don
Russian Federation
Russian Federation
References
1. Paches A.I., Ol'shanskij V.O., Lyubaev V.L., Tuok T.H. Zlokachestvennye opuholi polosti rta, glotki i gortani [Malignant tumors of oral cavity, pharynx and larynx]. Мoscow, Мeditsina Publ., 1988. 304 p.
2. Rukovodstvo po onkologii [Guide to Oncology] by eds V.I. Chissov, S.L. Dar'yalova. Moscow, OOO “Medicinskoe informacionnoe agentstvo” Publ., 2008. 904 p.
3. Sostoyanie onkologicheskoj pomoshchi naseleniyu Rossii v 2016 godu [Evaluation of the oncological help to the population of Russia in 2016] by eds Kaprin A.D., Starinskiy V.V. Moscow, MNIOI im. P.A. Gertsena – flial FGBU «NMIRC» Minzdrava Rossii Publ., 2017. 236 p.
4. Akopov A.L., Kazakov N.V., Rusanov A.A., Karlson A. The mechanisms of photodynamic action for treating of cancer patients, Photodynamic therapy and photodyagnosis, 2015, vol. 4, no. 2,, pp. 9–16. (in Russian) https://doi.org/10.24931/2413–9432–2015–4–2–9–16
5. Agarwal R., Korman N.J., Mohan R.R., Feyes D.K., Jawed S., Zaim M.T., Mukhtar H. Apoptosis is an early event during phthalocyanine photodynamic therapy-induced ablation of chemically induced squamous papillomas in mouse skin, J. Photochem Photobiol, 1996, vol. 63, no. 4, pp. 547–552.
6. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Brit. J. Cancer, 1972, vol. 26, pp. 239–257.
7. Oleinick N. L., Morris L., Varnes M. E. The peripheral benzodiazepine photosensitizer Pc4, J. Photochem. and Photobiol., 2002, vol. 75(6), pp. 652–661.
8. Krosl G., Korbelik M. Potentiation of photodynamic therapy by immunotherapy: the effect of schizophyllan (SPG), Cancer Lett., 1994, vol. 84, pp. 43–49.
9. Coutier S., Bezdetnaya L., Marchal S., Melnikova V., Belitchenko I., Merlin J.L., Guillemin F. Foscan (mTHPC) photosensitized mac-rophage activation: enhancement of phagocytosis, nitric oxide release and tumour necrosis factor-alpha-mediated cytolytic activity, Br. J. Cancer, 1999, Vol. 81, pp. 37–42.
10. Legostaev V.M., Babenkov O. Yu., Maldonado G. M., Islamova E.F., Balitsky G.V. Endoscopic photodynamic therapy of malignant tumors as a method of choice with exhausted possibilities of other methods of treatment in Materials XLIX International Scientifc and Practical Conference “Application of Lasers in Medicine and Biology” and “2nd Gamaleia’s Readings”. Kharkiv, 2018. 42–47 p.
11. Kravchenko A.B., Legostaev V.M., Babenkov O.Yu., Nosov V.A. Skriningovaya ehzofagoskopiya u patsientov, napravlennykh na endoskopicheskoe issledovanie dyhatel'nyh putej [Screening esophagoscopy in patients aimed at endoscopic examination of the respiratory tract] in Vserossijskaya molodezhnaya konferenciya «Aktualnye voprosy eksperimentalnoi i klinicheskoj onkologii. Sbornik tezisov. Rostov-na-Donu, 2016. p. 60.
Review
For citations:
Legostaev V.M., Babenkov O.Y., Balitskiy G.V. Combined endoscopic treatment of a patient with cancer of the hypopharynx to the upper third of the esophagus with complete clinical and endoscopic effect. Biomedical Photonics. 2018;7(4):35-40. https://doi.org/10.24931/2413-9432-2018-7-4-35-40
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