Preview

Biomedical Photonics

Advanced search

Intraoperative fluorescence diagnosis in patients with brain metastases (medical technology)

Abstract

The technique of intraoperative fluorescence diagnosis with alasens for brain metastases includes visual assessment of alasens-induced protoporphyrin IX fluorescence and local spectroscopy. The technique allows to reduce the rate of misdiagnosis, to assess accurate local extent of brain metastases and to improve surgical radicality. When applying this technique the sensitivity of fluorescence diagnosis is 96.7%, the specificity is 100%. The technique is designed for neurosurgeons specialized on neurooncology.

 

About the Authors

A. M. Zaytsev
P.A. Herzen Moscow Cancer Research Institute, Moscow
Russian Federation


M. I. Kurzhupov
P.A. Herzen Moscow Cancer Research Institute, Moscow
Russian Federation


E. V. Filonenko
P.A. Herzen Moscow Cancer Research Institute, Moscow
Russian Federation


References

1. Лошаков В.А. // Клиническая неврология / Под ред. А.Н. Коновалова. – М., 2005. – Т. 3, ч. 1. – С. 402–408.

2. Larson D., Rubenstein J., McDermott M. // Cancer Principles and Practice of Oncology /Eds V. T. Jr. De Vita et al. – Philadelphia, 2004. – P. 2323–2398.

3. Pollock B.E., Brown P.D., Foote R.L. et al. // J. Neurooncol. – 2003. – Vol.61 – P. 73–80. 4. Posner J.B. // Rev. Neurol. (Paris). – 1992. – Vol. 148. – P. 477–487.

4. Lang F.F., Sawaya R. Metastatic Brain Tumors; Neurooncology. – 2-nd Ed. – 2008. – P. 367–369.

5. Lang FF, Sawaya R. // Neurosurg. Clin. N. Am. – 1996. – Vol. 7. – P. 459–484.

6. Hojo S., Hirano A. // Metastatic Tumors of the Nervous System / Eds K. takura et. al. – Tokyo, 1982. – P. 5–111.

7. Delattre J.Y., Krol G., Thaler H.T., Posner J.B. // Arch. Neurol. – 1988. – Vol. 45. – P. 741–744.

8. Nussbaum E.S., Djalilian H.R., Cho K.H., Hall W.A. // Cancer. – 1996. – Vol. 78. – P. 1781–1788.

9. Sawaya R., Bindal R.K. Metastatic brain tumors. // Brain Tumors: An Encyclopedic Approach / Eds A.H. Kaye, E.R. Laws. – Edinburgh, 1995. – P. 923–946.

10. Decker D.A., Decker V.L., Herskovic A., Cummings G.D. // J. Clin. Oncol. – 1984. – Vol.2. – P. 169–173.

11. Gay P.C., Litchy W.J., Cascino T.L. // J. Neurooncol. – 1987. – Vol. 5. – P. 51–56.

12. Posner J.B., Chernik N.L. // Adv. Neurol. – 1978. – Vol. 19. – P. 579–592.

13. Henson R.A., Urich H. Cancer and the Nervous System. – London, 1982. 15. Haar F., Patterson R.H.J. // Cancer. – 1972. – Vol. 30. – P. 1241– 1245.

14. Mechta M., Khuntia D. // J. Neurosurg. – 2005. – Vol.57, N 5. – P. 4–35.

15. Stummer W. et al. // Lancet. Oncol. – 2006. – Vol. 7. – P. 392– 401.

16. Potapov A.A., Usachev D.J., Loshakov V.A. et al. // Med. Laser Appl. – 28 July 2008. – P. 1-7.

17. Малкаров М.С., Древаль О.Н., Борзунов А.Н. и соавт. // Ж. Вопросы нейрохирургии. – 2010. – Т. 3. – С. 20–24.


Review

For citations:


Zaytsev A.M., Kurzhupov M.I., Filonenko E.V. Intraoperative fluorescence diagnosis in patients with brain metastases (medical technology). Photodynamic therapy and photodyagnosis. 2014;3(2):31-38. (In Russ.)

Views: 934


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2413-9432 (Print)