Photodynamic therapy of penile cancer
https://doi.org/10.24931/2413-9432-2020-9-1-42-46
Abstract
In this article we submit the case report of a patient with cT1N0M0 penile cancer diagnosis. The patient underwent two courses of photodynamic therapy (PDT) using Fotoditazin photosensitizer (PS) and ATKUS-2 diode laser. The PS was administered at a dose of 1 mg/kg of body weight 2 hours prior to the PDT session. The irradiation parameters were: 662 nm laser wavelength, 200 mW/cm2 power density and 250 J/cm2 energy density. In the presented clinical observation, we demonstrated that PDT is an effective and safe treatment method in patients with non-invasive penile cancer. The use of photodynamic therapy allowed preserving the physiological urination, sexual function and achieving a good cosmetic effect.
About the Authors
D. M. Yagudaev
Peoples’ Friendship University of Russia
Россия
Moscow
Россия
Moscow
G. P. Gens
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Россия
Moscow
Россия
Moscow
Z. A. Kadyrov
Peoples’ Friendship University of Russia
Россия
Moscow
Россия
Moscow
A. V. Tikhonenko
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Россия
Moscow
Россия
Moscow
N. A. Kalyagina
Prokhorov General Physics Institute of the Russian Academy of Sciences
Россия
Moscow
Россия
Moscow
References
1. Klinicheskie rekomendacii. Rak polovogo chlena. Ministerstvo zdravoohraneniya Rossijskoj Federatsii [Clinical recommendations. Penile cancer. Ministry of Health of the Russian Federation]. 2017. 23 p. (in Russ.)
2. Al’-Shukri S. H., Korneev I. A., Giorgobiani T. G., Ageev M. N., Batmaev D. B. Penile cancer, Urologicheskie vedomosti, 2013, vol. 3, no. 1, pp. 28–32. (in Russ.)
3. Matveev B. P., Matveev V. B., Halaf’yan E. A., Volkova M. I. Regional metastases in penile cancer: what is the optimal treatment tactic?, Urologiya, 2004, no. 4, pp. 19–23. (in Russ.)
4. Bleeker M. C., Heideman D. A., Snijders P. J., Horenblas S., Dillner J., Meijer C. J. Penile cancer: epidemiology, pathogenesis and prevention. Prevention, World J. Urol., 2009, vol. 27, no. 2, pp. 141–150.
5. Maden C., Sherman K. J., Beckmann A. M., Hislop T. G., Teh C. Z., Ashley R. L., Daling J. R. History of circumcision, medical conditions, and sexual activity and risk of penile cancer, J. Nat. Canc. Inst., 1993, vol. 85, no. 1, pp. 19–24.
6. Halaf’yan E. A., Volkova M. I., Gurariy L. L., Zaharova T. I., Romanov V. A. Penile cancer prediction factors, Onkourologiya, 2005, no. 3, pp. 55–60. (in Russ.)
7. Mobilio G., Ficarra V. Genital treatment of penile carcinoma, Curr. Opin. Urol., 2001, vol. 11, pp. 299–304
8. Soria J. C., Fizazi K., Piron D., Kramar A., Gerbaulet A., Haie-Meder C., Perrin J. L., Court B., Wibault P., Théodore C. Squamous cell carcinoma of the penis: multivariate analysis prognosticfactors and natural history in monocentric study with aconservative policy, Ann. Oncol., 1997, vol. 8, pp. 1089–1098.
9. Harchenko V. P., Kaprin A. D., Titova V. A., Pan’shin G. A., Milenin K. N. Radiation diagnosis and complex treatment of penile cancer, Voprosy onkologii, 2006, vol. 52, no. 3, pp. 315–321. (in Russ.)
10. Gotsadze D., Matveev B., Zak B., Mamaladze V. Is conservativeorgan-sparing treatment of penile carcinoma justified?, Europ. Urol., 2000, Vol. 38, pp. 306–312.
11. Koch M. O., Smith J. A.Jr. Local recurrence of squamous cell carcinoma of the penis, Urol. Clin. North Amer., 1994, vol. 21 (4), pp. 739–743
12. Yagudaev D. M., Engay V. A., Alferov A. S., Ayvazyan D. R., Purtskhvanidze V. A. Radiation diagnosis and complex treatment of penile cancer, Lazernaya meditsina, 2015, vol. 19, no. 1, pp. 37–39. (in Russ.)
13. Oleinick N. L., Morris L., Varnes M. E. The peripheral benzodiazepine receptor in photodynamic therapy with the phthalocyanine photosensitizer Pc4, J. Photochem. and Photobiol., 2002, vol. 75 (6), pp. 652–661.
Review
For citations:
Yagudaev D.M., Gens G.P., Kadyrov Z.A., Tikhonenko A.V., Kalyagina N.A. Photodynamic therapy of penile cancer. Biomedical Photonics. 2020;9(1):42-46. https://doi.org/10.24931/2413-9432-2020-9-1-42-46
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