Photodynamic therapy of cancer of large duodenal papilla and extrahepatic bile ducts
https://doi.org/10.24931/2413-9432-2020-9-2-18-28
Abstract
The problem of treating patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla remains relevant due to the growing incidence, high mortality, and a pronounced decrease in the quality of life of patients, despite the radical surgery. The purpose of this study was to evaluate the effectiveness of photodynamic therapy (PDT) in inoperable patients with malignant tumors of these localizations.
The study is based on the treatment of 79 patients with adenocarcinoma of large duodenal papilla and extrahepatic bile ducts. 29 patients received palliative bile drainage operations with PDT. 50 patients in the control group only had palliative bile drainage operations. Patients in the study group received from 1 to 3 PDT courses in a year. In total, 29 patients received 52 PDT courses. The tolerance to the method and the life expectancy of patients were evaluated. The median survival of patients who underwent PDT was 18 months (11–60 months); in the control group – 11.5 months. PDT, in combination with bile drainage operation, is an effective method for the treatment of inoperable patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla in the absence of severe complications and with easy tolerance to therapy by patients. For the treatment and prolongation of life of patients whose radical surgical treatment is associated with a high risk of death, PDT seems to be the best treatment option. Results of PDT treatment for cancer of this localization are comparable with the results of radical surgeries and exceed those for palliative surgeries.
About the Authors
E. F. Stranadko
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Moscow
Russian Federation
Moscow
A. V. Baranov
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Moscow
Russian Federation
Moscow
V. A. Duvansky
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Moscow
Russian Federation
Moscow
A. I. Lobakov
Moscow Regional Research and Clinical Institute (“MONIKI”)
Russian Federation
Moscow
Russian Federation
Moscow
V. A. Morokhotov
Moscow Regional Research and Clinical Institute (“MONIKI”)
Russian Federation
Russian Federation
Moscow
M. V. Riabov
Skobelkin State Scientific Center of Laser Medicine FMBA
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Stranadko E.F., Baranov A.V., Duvansky V.A., Lobakov A.I., Morokhotov V.A., Riabov M.V. Photodynamic therapy of cancer of large duodenal papilla and extrahepatic bile ducts. Biomedical Photonics. 2020;9(2):18-28. https://doi.org/10.24931/2413-9432-2020-9-2-18-28
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