Therapeutic pathomorphosis in malignant glioma tissues after photodynamic therapy with сhlorin e6 (reports of two clinical cases)
https://doi.org/10.24931/2413-9432-2020-9-2-45-54
Abstract
In recent years, photodynamic therapy (PDT) has been increasingly introduced into the surgical practice of treating malignant neoplasms. In this publication, the authors show the appearance of therapeutic pathomorphosis in vivo in human malignant glioma cells after intraoperative photodynamic therapy. Tissue samples obtained 10–14 days after PDT revealed nuclear and cytoplasmic signs indicating apoptosis, necrosis, and autophagy. A decrease in the proliferative activity of glial tumor cells and their higher death count were detected.. Immunohistochemical analysis shows decreases expression of Ki-67 cell proliferation marker and decreased amount of transcription factor protein p53.
About the Authors
A. Yu. Rynda
Russian Neurosurgical Institute named after Professor A.L. Polenov - a branch of «The National Medical Research Center named after V.A. Almazov»
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
D. M. Rostovtsev
Russian Neurosurgical Institute named after Professor A.L. Polenov - a branch of «The National Medical Research Center named after V.A. Almazov»
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. E. Olyushin
Russian Neurosurgical Institute named after Professor A.L. Polenov - a branch of «The National Medical Research Center named after V.A. Almazov»
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
Yu. M. Zabrodskaya
Russian Neurosurgical Institute named after Professor A.L. Polenov - a branch of «The National Medical Research Center named after V.A. Almazov»
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
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Review
For citations:
Rynda A.Yu., Rostovtsev D.M., Olyushin V.E., Zabrodskaya Yu.M. Therapeutic pathomorphosis in malignant glioma tissues after photodynamic therapy with сhlorin e6 (reports of two clinical cases). Biomedical Photonics. 2020;9(2):45-54. https://doi.org/10.24931/2413-9432-2020-9-2-45-54
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