Photodynamic therapy and diagnosis of lower lip cancer with photosense
Abstract
Results of diagnosis and treatment in 32 patients with lower lip cancer using photodynamic therapy (PDT) with photosensitizer Photosense are represented. 15 patients had stage I of disease, in 12 – stage II and in 5 – stage III. Photosensitizer Photosense was administered at dose of 0.5 mg/kg body weight in 20 patients and at dose of 0.8 mg/kg – in 12 patients as single intravenous infusion. During the treatment the fluorescent diagnosis (FD) was performed. The average power of diagnostic laser irradiation was 2 mW, light dose on tissue surface was < 1 J/cm2. Power density of therapeutic laser irradiation accounted for 150–300 mW/cm2, light dose of one session was 200-300 J/cm2. First session of PDT was performed 24 h after drug injection, the interval between following sessions accounted for 24 h. The number of session varied from 3 to 5. The results of FD showed the increase of fluorescent intensity in the center of tumor from 14.9 up to 150.8 r.u. 24 h after drug injection, this parameter in the normal mucosa increased from 13,4 to 88,3 r.u. The side-effects of PDT with Photosense included pain syndrome, which was managed by non-opioid analgesics in all 10 patients. The signs of phototoxycity were observed in 9 patients. Two months after PDT 22 (68.7%) patients had complete regression of tumor lesion, the response in 8 (25%) patients was defined as partial, 2 (6.3%) patients had stabilization of tumor growth.
About the Authors
S. V. Evstigneev
N.P. Ogarev Medical State University, Saransk
Russian Federation
Russian Federation
M. T. Kulaev
N.P. Ogarev Medical State University, Saransk
Russian Federation
Russian Federation
O. A. Rybkina
N.P. Ogarev Medical State University, Saransk
Russian Federation
Russian Federation
References
1. Давыдов М.И., Аксель Е.М. Заболеваемость злокачественными новообразованиями населения России и стран СНГ в 2010 г. // Вестник РОНЦ им. Н.П. Блохина РАМН. – 2011. – Т. 20. – № 2 (прил. 1). – С. 52–89.
2. Федяев И.М., Байриков И.М., Белова Л.П., Шувалова Т.В. Злокачественные опухоли челюстно-лицевой области. – М.: Медицинская книга, 2010. – С. 160.
3. Зикиряходжаев Д.З., Хабибулаев Ш.З. Хирургическое лечение рака губы и слизистой оболочки полости рта // Сибирский онкологический журнал. – 2009. – Приложение № 2. – С. 77.
4. Странадко Е.Ф., Титова В.А., Рябов М.В. Фотодинамическая терапия рака нижней губы: опыт применения в комбинации с традиционными методами профилактики метастазирования // Лазерная медицина. – 2010. – Т. 10. − № 3. – С. 41–47.
5. Вакуловская Е.Г., Стратонников А.А., Таболиновская Т.Д., Кондратьева Т.Т. Фотодинамическая терапия у больных раком слизистой оболочки полости рта, ротоглотки и нижней губы // Сибирский онкологический журнал. – 2009. – Т. 14. – № 2. – С. 13–17.
6. Полькин В.В., Спиченкова И.С., Каплан М.А. и др. Фотодинамическая терапия в лечении плоскоклеточного рака слизистой оболочки полости рта и нижней губы // Фотодинамическая терапия и фотодиагностика. – 2013. – №1. – С. 11–19.
Review
For citations:
Evstigneev S.V., Kulaev M.T., Rybkina O.A. Photodynamic therapy and diagnosis of lower lip cancer with photosense. Photodynamic therapy and photodyagnosis. 2014;3(3):20-24. (In Russ.)
Views:
1033
Email this article 