Fluorescence diagnosis of pre-tumor and tumor pathology of endometrium
Abstract
The technique of fluorescence hysteroscopy with Alasens includes visual assessment of fluorescence of Alasens-induced protoporphyrin IX and local fluorescence spectroscopy. The technique allows to improve the efficacy of early diagnosis for endometrial pathology including early endometrial cancer, to assess definitely an extent of pre-tumor and tumor process. The sensitivity of fluorescence hysteroscopy accounts for 100%, the specificity – 98%.
About the Authors
E. V. Filonenko
P.A.Herzen Moscow Cancer Research Institute
Russian Federation
Russian Federation
O. V. Chulkova
P.A.Herzen Moscow Cancer Research Institute
Russian Federation
Russian Federation
E. G. Novikova
P.A.Herzen Moscow Cancer Research Institute
Russian Federation
Russian Federation
L. G. Serova
P.A.Herzen Moscow Cancer Research Institute
Russian Federation
Russian Federation
References
1. Ашрафян Л.А., Харченко Н.В., Огрызкова В.Л. Современные принципы первичной и уточняющей диагностики рака эндометрия // Практическая онкология. – 2004. – Т. 5, №1. – С. 16–24.
2. Чиссов В.И., Соколов В.В., Филоненко Е.В. Флюоресцентная эндоскопия, дермаскопия и спектрофотометрия в диагностике злокачественных опухолей основных локализаций // Российский биотерапевтический журнал. – 2003. – №4. – С. 45–56.
3. Hurnung R., Fehr M., Major A., Tadir Y. Uptake of the photosensitizer benzoporphyrin derivative in human endometrium after topical application in vivo // J. Am Assoc Gynecol. Laparosc. – 1998. – Vol. 5, No 4. – P. 367–74.
4. Fehr M.K., Wyss P., Tadir Y. Selective photosensitizer localization in the human endometrial after intrauterine application of 5-aminolevulinic acid // Obstetrics Am J Obstet Gynecol. – 2003. – Vol. 175, No 5. – P. 1253–9.
5. Sabban F., Collinet P., Cosson M., Mordon S. Fluorescence imaging technique: diagnostic and therapeutic interest in gynecology // J.Gynecol. Biol. Reprod. – 2004. – Vol. 33, No 8. – P. 734–8.
6. Лукин В.А, Филоненко Е.В, Вашакмадже Л.А. Флюоресцентная лапароскопия у больных раком желудка // Фотодинамическая терапия и фотодиагностика. – 2013. – №4. – C. 17–25.
7. Lang K, Lehmann P, Bolsen K. Aminolevulinic acid pharmacological profile and clinical indication // Obstetrics Expert Opin Investig Drugs. – 2001. – Vol. 72, No 10. – P. 829–37.
8. Malik E., Berg C., Meyhofer-Malik A., Buchweitz O. et al. Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid // Surg. Endosc. – 2000. – Vol. 14, No 5. – P. 452–455.
9. Nowis D., Makowski M., Legat M., Golab J. Direct tumor damage mechanisms of photodynamic therapy // Obstetrics Acta Biochim Pol. – 2005. – Vol. 52, No 2. – P. 339–52.
10. Wyss P. Haller U. Berns MW. Accumulation of 5-aminolevulinic acid – induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cell // Obstetrics Biochim Biohys Res Commum. – 2006. – Vol. 224, No 3. – P. 819–24.
Review
For citations:
Filonenko E.V., Chulkova O.V., Novikova E.G., Serova L.G. Fluorescence diagnosis of pre-tumor and tumor pathology of endometrium. Photodynamic therapy and photodyagnosis. 2014;3(3):25-30. (In Russ.)
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